Between the 2000 and 2020 seasons, the New York Yankees had the most wins by a team, with 1,919 wins.

Interpreted as:

most MLB team regular-season wins from 2000 to 2020

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	1,919	1,377	.582	3,298	113,277	17,058	30,149	5,753	438	4,429	16,358	12,127	1,343	23,235	2,057	653	128,224	50,065	10,620	545	932	667	2,663	.266	.342	.442	.784
2	Cardinals	1,842	1,455	.559	3,297	112,230	15,654	29,739	5,832	517	3,573	14,880	11,034	1,307	22,760	1,514	708	126,817	47,324	9,922	1,312	934	1,028	2,654	.265	.335	.422	.757
3	Dodgers	1,824	1,476	.553	3,300	112,070	14,840	28,940	5,618	582	3,466	14,119	11,087	1,174	23,220	1,907	765	126,380	46,120	9,666	1,216	833	941	2,566	.258	.329	.412	.741
4	Red Sox	1,816	1,483	.550	3,299	114,954	17,041	31,206	6,881	553	3,895	16,226	11,936	1,172	23,358	1,700	577	129,527	50,878	11,329	446	1,019	862	2,695	.271	.343	.443	.786
5	Braves	1,770	1,527	.537	3,298	112,682	15,129	29,379	5,868	532	3,470	14,429	11,127	1,035	23,960	1,610	680	126,981	46,721	9,870	1,303	834	971	2,621	.261	.331	.415	.745
6	Athletics	1,765	1,533	.535	3,298	112,760	15,416	28,600	5,929	499	3,623	14,690	11,708	1,125	23,155	1,461	511	126,949	46,396	10,051	440	916	559	2,668	.254	.328	.411	.739
7	Angels	1,748	1,552	.530	3,300	113,042	15,468	29,889	5,742	554	3,472	14,717	10,098	1,133	21,457	2,295	914	125,983	47,155	9,768	738	972	775	2,611	.264	.328	.417	.745
8	Indians	1,706	1,592	.517	3,298	112,871	15,722	29,505	6,189	527	3,647	14,994	11,351	1,261	23,733	1,856	733	127,195	47,689	10,363	744	968	636	2,558	.261	.333	.423	.756
9	Giants	1,705	1,592	.517	3,298	112,565	14,396	29,127	5,862	755	3,060	13,689	10,477	983	22,350	1,512	680	126,206	45,679	9,677	1,235	946	1,141	2,632	.259	.325	.406	.731
10	Phillies	1,665	1,634	.505	3,299	112,926	15,059	28,799	5,814	681	3,578	14,342	11,270	1,230	24,601	2,059	577	127,348	46,709	10,073	1,115	807	1,029	2,301	.255	.327	.414	.741
11	Twins	1,664	1,637	.504	3,301	113,557	15,330	29,909	6,030	679	3,252	14,531	10,520	1,031	22,956	1,818	780	126,689	47,053	9,961	651	930	693	2,598	.263	.329	.414	.743
12	Cubs	1,658	1,640	.503	3,299	112,485	14,820	28,768	5,857	589	3,693	14,109	10,780	1,232	25,031	1,481	687	126,524	46,882	10,139	1,228	799	881	2,483	.256	.325	.417	.742
13	Astros	1,650	1,649	.500	3,300	112,161	15,041	28,930	5,822	555	3,701	14,324	10,651	1,235	23,850	1,926	808	126,017	46,965	10,078	1,092	878	725	2,631	.258	.327	.419	.745
14	Rangers	1,641	1,660	.497	3,301	113,738	16,371	30,128	6,031	578	4,117	15,585	10,322	1,225	23,882	1,978	747	126,921	49,666	10,726	683	953	620	2,456	.265	.330	.437	.767
15	White Sox	1,635	1,665	.495	3,300	112,581	15,221	29,302	5,501	505	3,949	14,593	9,700	1,261	23,411	1,897	889	125,207	47,660	9,955	793	872	500	2,568	.260	.324	.423	.747
16	Mets	1,634	1,664	.495	3,298	112,198	14,409	28,473	5,679	564	3,380	13,741	10,851	1,171	23,663	2,007	719	126,265	45,420	9,623	1,200	845	967	2,475	.254	.324	.405	.729
17	Blue Jays	1,631	1,668	.494	3,299	113,132	15,632	29,236	6,161	503	4,026	14,915	10,615	1,163	23,419	1,586	605	126,334	48,481	10,690	511	913	522	2,657	.258	.326	.429	.755
18	Diamondbacks	1,623	1,677	.492	3,300	112,824	14,919	28,885	5,978	829	3,476	14,241	10,925	1,033	24,653	1,823	713	126,764	46,949	10,283	1,078	904	934	2,401	.256	.325	.416	.741
19	Mariners	1,622	1,678	.492	3,300	113,028	14,510	29,078	5,474	520	3,312	13,787	10,174	1,069	23,462	2,093	801	125,876	45,528	9,306	728	877	708	2,431	.257	.322	.403	.725
20	Nationals	1,616	1,682	.490	3,298	111,649	14,472	28,578	5,852	569	3,336	13,766	10,764	1,122	24,150	1,941	784	125,750	45,576	9,757	1,351	864	956	2,498	.256	.325	.408	.733
21	Brewers	1,594	1,706	.483	3,301	111,804	14,612	28,322	5,751	583	3,804	13,964	10,657	1,365	26,203	2,101	770	125,787	46,651	10,138	1,161	800	831	2,526	.253	.324	.417	.741
22	Rays	1,594	1,704	.483	3,298	112,241	14,607	28,576	5,704	675	3,458	13,919	10,710	1,260	25,022	2,435	918	125,749	46,004	9,837	625	913	575	2,344	.255	.324	.410	.734
23	Reds	1,557	1,743	.472	3,302	112,257	14,678	28,471	5,623	499	3,777	14,014	10,926	1,304	25,323	1,995	792	126,602	46,423	9,899	1,304	811	884	2,363	.254	.325	.414	.738
24	Marlins	1,549	1,747	.470	3,296	112,236	14,072	28,810	5,636	665	3,086	13,346	10,082	1,221	25,034	2,039	814	125,599	45,034	9,387	1,233	827	862	2,464	.257	.323	.401	.724
25	Rockies	1,547	1,755	.469	3,302	113,547	16,339	30,730	6,128	878	3,680	15,539	10,690	986	24,778	1,914	835	127,517	49,654	10,686	1,402	892	887	2,476	.271	.336	.437	.774