Between the 2018 and 2021 seasons, Mookie Betts had the most runs, with 404 runs.

Interpreted as:

most runs by a player from 2018 to 2021

	NAME	R	G	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Mookie Betts M. Betts	404	463	1,802	543	125	14	100	257	270	24	316	66	16	2,116	996	239	0	20	17	23	.301	.396	.553	.948	400	141.8	.397	150	130
2	Freddie Freeman F. Freeman	378	539	2,029	620	126	9	105	355	293	24	403	26	9	2,356	1,079	240	0	10	45	45	.306	.398	.532	.929	431	143.9	.390	142	126.2
3	Marcus Semien M. Semien	355	536	2,152	568	126	12	100	287	239	6	429	43	15	2,410	1,018	238	2	11	3	35	.264	.338	.473	.811	351	57.5	.345	119	58.7
4	Trea Turner T. Turner	352	491	2,013	608	113	18	78	248	175	16	391	122	23	2,214	991	209	2	8	7	40	.302	.361	.492	.854	355	86.2	.363	126	72.3
5	Bryce Harper B. Harper	343	515	1,801	488	121	4	117	331	378	19	524	49	11	2,220	968	242	3	19	49	34	.271	.399	.537	.937	406	135.6	.390	143	120.7
6	Charlie Blackmon C. Blackmon	338	505	1,941	570	110	19	80	276	172	30	373	19	10	2,159	958	209	1	15	8	33	.294	.358	.494	.851	343	79.9	.361	111	31.5
7	Juan Soto J. Soto	337	464	1,612	485	91	8	98	312	373	6	352	32	12	2,003	886	197	1	11	48	44	.301	.432	.550	.981	401	156.6	.410	156	143.2
8	José Ramírez J. Ramírez	334	496	1,831	490	119	13	115	337	261	20	284	95	17	2,130	980	247	0	18	28	25	.268	.362	.535	.897	360	101.1	.374	137	96.9
9	Francisco Lindor F. Lindor	333	486	1,947	518	111	7	98	256	198	20	342	63	21	2,189	937	216	10	14	22	33	.266	.338	.481	.819	317	51.2	.345	117	45.7
10	Ozzie Albies O. Albies	331	503	2,026	551	128	20	84	283	142	13	386	52	12	2,196	971	232	1	14	8	15	.272	.322	.479	.801	306	38.8	.337	108	21.8
11	Whit Merrifield W. Merrifield	328	542	2,225	652	138	16	47	238	158	19	376	117	27	2,427	963	201	2	23	8	35	.293	.342	.433	.775	326	30	.332	106	18.3
12	Trevor Story T. Story	328	503	1,947	547	127	20	107	296	182	25	544	85	23	2,166	1,035	254	0	12	6	27	.281	.348	.532	.880	359	95.2	.369	117	46.6
13	Christian Yelich C. Yelich	327	452	1,662	488	89	13	101	280	264	19	442	65	11	1,953	906	203	0	8	25	31	.294	.395	.545	.940	364	126.8	.394	147	115.5
14	Paul Goldschmidt P. Goldschmidt	325	535	1,984	562	109	8	104	300	272	13	518	23	5	2,278	999	221	0	9	15	35	.283	.372	.504	.875	381	103.7	.371	134	98.2
15	DJ LeMahieu	324	473	1,927	575	99	7	61	248	174	10	287	18	9	2,131	871	167	3	17	2	47	.298	.357	.452	.809	315	54.9	.347	116	43.3
16	J.D. Martinez	323	498	1,925	571	128	7	114	361	218	13	493	9	1	2,175	1,055	249	0	19	29	62	.297	.369	.548	.917	382	117.2	.381	138	100.3
17	Ronald Acuña Jr. R. Acuña Jr.	323	395	1,516	426	78	7	105	246	208	28	456	78	21	1,761	833	190	0	9	10	15	.281	.376	.549	.925	320	104.1	.388	140	90.6
18	Jose Altuve J. Altuve	322	455	1,827	527	97	6	80	236	179	14	291	30	15	2,035	876	183	5	10	7	50	.288	.355	.479	.834	313	65.8	.355	127	67.9
19	Rafael Devers R. Devers	321	490	1,920	535	131	6	102	337	161	14	450	18	15	2,104	984	239	1	8	20	38	.279	.338	.513	.850	326	68.5	.355	120	52
20	Nick Castellanos N. Castellanos	320	506	1,984	576	153	11	98	296	150	22	484	7	6	2,169	1,045	262	0	13	12	41	.290	.345	.527	.872	351	87.3	.365	126	71.8
21	Nolan Arenado N. Arenado	310	516	1,953	557	112	7	121	359	200	10	331	7	4	2,189	1,046	240	1	25	32	57	.285	.351	.536	.886	359	92.3	.367	121	57.2
22	Xander Bogaerts X. Bogaerts	308	491	1,859	555	139	4	90	327	214	13	378	25	5	2,106	972	233	0	20	10	41	.299	.371	.523	.894	362	105.4	.376	134	88.9
23	Max Muncy M. Muncy	307	480	1,582	389	69	5	118	298	291	28	460	10	2	1,910	822	192	0	9	14	19	.246	.371	.520	.890	327	93.7	.376	138	91.1
24	Starling Marte S. Marte	303	458	1,793	523	104	15	61	236	115	46	343	115	27	1,968	840	180	4	10	6	37	.292	.348	.468	.817	292	52.2	.348	118	46
25	Manny Machado M. Machado	301	531	2,007	563	99	8	113	345	224	10	371	37	11	2,264	1,017	220	0	23	35	69	.281	.352	.507	.859	354	78.5	.358	128	78.5