The Boston Red Sox had their most runs in a game against the St. Louis Browns on June 8, 1950, with 29 runs.

Interpreted as:

most runs scored regular-season game by red sox

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Red Sox	29	6/8/1950	BSA	vs	SLA	W 29-4	53	28	9	1	7	29	11	0	2	0	0	64	60	17	0		0	0	.528	.609	1.132	1.741
2	Red Sox	25	6/27/2003	BOS	vs	FLA	W 25-8	46	28	8	1	3	25	7	1	7	0	0	57	47	12	0	3	0	1	.609	.632	1.022	1.653
3	Red Sox	24	8/21/1986	BOS	@	CLE	W 24-5	51	24	2	0	3	23	9	1	2	0	0	61	35	5	0	0	0	0	.471	.557	.686	1.244
4	Red Sox	24	9/27/1940	BSA	vs	WSH	W 24-4	44	22	4	1	2	21	9	0	6	0	0	53	34	7	0			2	.500	.585	.773	1.358
5	Red Sox	23	6/18/1953	BOS	vs	DET	W 23-3	50	27	2	0	1	22	9	0	6	1	1	60	32	3	1		1	0	.540	.610	.640	1.250
6	Americans	23	5/2/1901	BSA	@	PHA	W 23-12	47	21	7	3	0	21	7	0	0	1	-9	55	34	10	1		-9	-9	.447	.519	.723	1.242
7	Red Sox	22	8/15/2015	BOS	vs	SEA	W 22-10	47	26	7	0	4	22	6	1	3	1	0	57	45	11	0	3	0	1	.553	.579	.957	1.536
8	Red Sox	22	7/23/2002	BOS	vs	TBD	W 22-4	44	19	5	0	7	21	7	0	4	1	0	51	45	12	0	0	0	0	.432	.510	1.023	1.533
9	Red Sox	22	4/12/1994	BOS	@	KCR	W 22-11	41	15	4	2	5	19	13	2	5	1	0	57	38	11	0	1	0	1	.366	.526	.927	1.453
10	Red Sox	22	6/29/1950	BSA	@	PHA	W 22-14	47	19	4	1	1	21	11	1	5	1	0	60	28	6	1		0	1	.404	.525	.596	1.121
11	Red Sox	21	8/30/1970	BOS	@	CWS	W 21-11	47	22	5	1	2	21	10	0	5	2	0	57	35	8	0	0	1	1	.468	.561	.745	1.306
12	Red Sox	21	6/24/1949	BSA	vs	SLA	W 21-2	48	25	3	0	2	20	12	0	4	2	0	60	34	5	0			1	.521	.617	.708	1.325
13	Red Sox	21	5/29/1912	BSA	vs	WSH	W 21-8	41	18	5	0	1	17	11	1	3	3		53	26	6	0				.439	.566	.634	1.200
14	Red Sox	20	8/11/2021	BOS	vs	TBR	W 20-8	42	19	7	2	1	20	9	2	6	0	0	53	33	10	0	0	2	1	.452	.566	.786	1.352
15	Red Sox	20	9/4/2013	BOS	vs	DET	W 20-4	41	19	4	0	8	20	4	2	10	1	0	48	47	12	0	1	1	1	.463	.521	1.146	1.667
16	Red Sox	20	9/6/1975	BOS	@	MIL	W 20-6	50	24	5	0	3	20	3	0	4	0	0	54	38	8	0	1	0	1	.480	.500	.760	1.260
17	Red Sox	20	5/31/1954	BOS	vs	PHA	W 20-10	42	18	2	2	3	19	11	2	4	1	0	55	33	7	0	0	2	0	.429	.564	.786	1.349
18	Red Sox	20	6/7/1950	BSA	vs	SLA	W 20-4	45	23	4	0	5	20	7	0	7	0	0	52	42	9	0		0	1	.511	.577	.933	1.510
19	Red Sox	19	5/23/2025	BOS	vs	BAL	W 19-5	45	20	6	0	3	19	8	0	7	0	0	53	35	9	0	0	0	1	.444	.528	.778	1.306
20	Red Sox	19	7/25/2019	BOS	vs	NYY	W 19-3	46	23	10	0	4	19	5	0	6	0	0	51	45	14	0	0	0	0	.500	.549	.978	1.527
21	Red Sox	19	9/26/2018	BOS	vs	BAL	W 19-3	45	22	9	0	5	19	3	0	7	1	0	48	46	14	0	0	0	1	.489	.521	1.022	1.543
22	Red Sox	19	8/10/2018	BOS	@	BAL	W 19-12	41	16	5	1	3	18	10	1	6	1	0	53	32	9	0	1	1	1	.390	.509	.780	1.290
23	Red Sox	19	8/12/2008	BOS	vs	TEX	W 19-17	40	17	4	0	4	18	10	0	6	2	1	50	33	8	0	0	1	2	.425	.540	.825	1.365
24	Red Sox	19	8/5/1979	BOS	@	MIL	W 19-5	54	27	4	1	2	18	3	0	5	0	0	59	39	7	0	2	0	1	.500	.508	.722	1.231
25	Red Sox	19	4/30/1950	BSA	vs	PHA	W 19-0	41	17	3	1	4	16	8	0	4	0	0	50	34	8	1		0	1	.415	.510	.829	1.339