Derek Jeter has put up the most career runs on Wednesdays, with 330 runs.

Interpreted as:

most runs by a player scored on a wednesday

	NAME	R	G	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Derek Jeter D. Jeter	330	417	1,715	520	98	9	45	185	161	29	307	53	9	1,926	771	152	13	8	6	45	.303	.371	.450	.821
2	Ty Cobb T. Cobb	328	430	1,615	598	96	38	10		185	16		132		1,861	800	144	45				.370	.440	.495	.935
3	Hank Aaron H. Aaron	325	475	1,789	574	96	18	111	346	190	6	186	39	12	2,009	1,039	225	5	19	38	54	.321	.384	.581	.965
4	Rickey Henderson R. Henderson	322	462	1,592	411	88	11	34	142	343	14	250	175	57	1,964	623	133	4	11	15	21	.258	.392	.391	.783
5	Barry Bonds B. Bonds	311	449	1,481	431	82	11	115	314	329	20	240	67	23	1,840	880	208	1	9	101	26	.291	.424	.594	1.018
6	Craig Biggio C. Biggio	301	439	1,644	487	108	12	38	194	199	43	252	68	22	1,916	733	158	10	20	12	20	.296	.382	.446	.828
7	Pete Rose P. Rose	301	520	2,030	599	105	24	18	171	232	19	184	22	21	2,301	806	147	6	14	29	43	.295	.370	.397	.767
8	Carl Yastrzemski C. Yastrzemski	286	487	1,767	512	103	8	73	276	263	5	226	23	20	2,051	850	184	1	15	33	44	.290	.380	.481	.862
9	Babe Ruth B. Ruth	282	359	1,210	416	77	13	91	304	276	8	204	20		1,508	792	181	14				.344	.469	.655	1.123
10	Mel Ott M. Ott	281	396	1,350	418	70	11	82	291	248	10	140	17		1,626	756	163	18			4	.310	.420	.560	.980
11	Alex Rodriguez A. Rodriguez	279	424	1,628	452	87	5	97	266	191	21	394	47	13	1,855	840	189	1	14	17	50	.278	.358	.516	.874
12	Frank Robinson F. Robinson	277	414	1,478	452	82	12	90	285	239	25	224	34	13	1,759	828	184	5	12	38	52	.306	.408	.560	.968
13	Willie Mays W. Mays	271	431	1,543	433	62	27	89	257	228	7	252	55	13	1,790	816	178	1	11	35	39	.281	.373	.529	.902
14	Mickey Mantle M. Mantle	270	350	1,189	361	45	11	90	248	259	1	253	22	6	1,455	698	146	2	4	17	16	.304	.427	.587	1.014
15	Tristram Speaker T. Speaker	269	414	1,493	518	118	36	10		208	18		59		1,774	738	164	55				.347	.433	.494	.927
16	Eddie Collins E. Collins	264	413	1,487	489	65	29	7		185	14		107		1,756	633	101	70				.329	.408	.426	.834
17	Charlie Gehringer C. Gehringer	263	342	1,339	401	77	18	25	200	166	5	53	28		1,531	589	120	21			4	.299	.379	.440	.819
18	Stan Musial S. Musial	261	423	1,512	522	113	30	52	271	228	15	100	11	5	1,771	851	195	5	11	16	29	.345	.433	.563	.996
19	Carlos Beltran C. Beltran	259	400	1,520	450	97	9	68	254	180	8	282	54	6	1,730	769	174	4	18	16	25	.296	.370	.506	.876
20	Rafael Palmeiro R. Palmeiro	258	415	1,522	430	85	5	93	267	207	13	200	15	9	1,760	804	183	1	17	27	35	.283	.370	.528	.898
21	Jim Thome J. Thome	257	374	1,245	360	61	2	97	252	255	6	379	5	7	1,513	716	160	0	7	34	28	.289	.410	.575	.986
22	Eddie Murray E. Murray	256	451	1,698	452	87	8	70	234	203	3	209	14	7	1,925	765	165	0	21	36	37	.266	.342	.451	.792
23	George Brett G. Brett	256	407	1,583	489	105	27	44	245	177	3	154	44	14	1,784	780	176	3	18	47	34	.309	.376	.493	.868
24	Chipper Jones C. Jones	253	386	1,398	432	90	5	81	280	213	2	209	21	3	1,627	775	176	0	14	28	31	.309	.398	.554	.952
25	Albert Pujols A. Pujols	251	453	1,690	494	105	4	72	274	186	22	206	18	6	1,914	823	181	0	16	42	58	.292	.367	.487	.854

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StatMuse has game-level data for runs going back to the 1901 season.

Some of the information used here was obtained free of charge from Retrosheet.

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Wed 3/25	NYY	@	SFG	8:05 PM
Fri 3/27	NYY	@	SFG	4:35 PM
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Tue 9/16	ATL	@	WSH	9-4
Tue 9/16	ATH	@	BOS	4-5
Tue 9/16	TOR	@	TBR	1-2
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Wed 3/25	NYY	@	SFG	8:05 PM
Thu 3/26	PIT	@	NYM	1:15 PM
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Derek Jeter has put up the most career runs on Wednesdays, with 330 runs.

Interpreted as:

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