Nolan Ryan has struck out the most hitters against left-handed batters in a season, with 207 strikeouts in 1977.
| NAME | SO | SEASON | TM | G | H | HR | BB | HBP | IBB | K/BB | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 207 | 1977 | 37 | 112 | 7 | 135 | 5 | 7 | 1.53 | |
| 2 |  | G. Cole | 182 | 2019 | 33 | 67 | 17 | 30 | 1 | 0 | 6.07 | |
| 3 |  | J. Verlander | 171 | 2019 | 34 | 66 | 17 | 25 | 6 | 0 | 6.84 | |
| 4 | | N. Ryan | 167 | 1974 | 42 | 91 | 7 | 90 | 4 | 3 | 1.86 | |
| 5 |  | J. Misiorowski | 161 | 2026 | 29 | 38 | 6 | 23 | 7 | 0 | 7.00 | |
| 6 | | G. Cole | 160 | 2018 | 32 | 56 | 7 | 38 | 3 | 0 | 4.21 | |
| 7 |  | R. Clemens | 160 | 1997 | 34 | 102 | 3 | 36 | 5 | 1 | 4.44 | |
| 8 |  | J. Verlander | 157 | 2009 | 35 | 125 | 14 | 37 | 0 | 3 | 4.24 | |
| 9 |  | T. Lincecum | 156 | 2009 | 32 | 96 | 8 | 41 | 1 | 1 | 3.80 | |
| 10 |  | C. Schlittler | 154 | 2026 | 32 | 77 | 9 | 32 | 3 | 0 | 4.81 | |
| 11 |  | G. Williams | 153 | 2026 | 31 | 75 | 13 | 32 | 5 | 0 | 4.78 | |
| 12 | | C. Schilling | 153 | 1998 | 35 | 124 | 12 | 39 | 1 | 2 | 3.92 | |
| 13 | | N. Ryan | 152 | 1978 | 31 | 113 | 4 | 81 | 3 | 7 | 1.88 | |
| 14 |  | Y. Darvish | 151 | 2013 | 32 | 97 | 16 | 49 | 5 | 1 | 3.08 | |
| 15 | | N. Ryan | 151 | 1976 | 38 | 92 | 4 | 97 | 0 | 1 | 1.56 | |
| 16 | | C. Schilling | 150 | 1997 | 35 | 107 | 16 | 34 | 3 | 0 | 4.41 | |
| 17 |  | P. Martinez | 149 | 1997 | 31 | 86 | 8 | 42 | 1 | 3 | 3.55 | |
| 18 |  | R. Clemens | 149 | 1996 | 34 | 120 | 10 | 74 | 3 | 2 | 2.01 | |
| 19 | | J. Verlander | 148 | 2018 | 34 | 62 | 14 | 21 | 5 | 0 | 7.05 | |
| 20 |  | P. Martinez | 148 | 1999 | 31 | 92 | 4 | 21 | 5 | 0 | 7.05 | |
| 21 | | R. Clemens | 147 | 1998 | 33 | 90 | 9 | 58 | 2 | 0 | 2.53 | |
| 22 | | J. Verlander | 145 | 2011 | 34 | 86 | 10 | 38 | 1 | 0 | 3.82 | |
| 23 |  | D. Cease | 144 | 2026 | 29 | 58 | 8 | 46 | 2 | 0 | 3.13 | |
| 24 | | J. Verlander | 144 | 2016 | 34 | 76 | 15 | 34 | 3 | 1 | 4.24 | |
| 25 |  | C. Kluber | 144 | 2014 | 34 | 114 | 10 | 36 | 2 | 1 | 4.00 | |
CAL
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TOR
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CLEStatMuse has event-level data for strikeouts going back to the 1974 season.
Some of the information used here was obtained free of charge from Retrosheet.
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