Tom Cheney has fanned the most batters in a game, with 21 strikeouts against the Orioles on September 12, 1962.
Interpreted as:
most strikeouts by a pitcher in a regular-season game| NAME | SO | DATE | TM | OPP | DEC | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | T. Cheney | 21 | 9/12/1962 |  WSH | @ |  BAL | W | 1 | 0.56 | 1 | 0 | 0 | 16.0 | 10 | 1 | 1 | 0 | 4 | 0 | 0 | 0 | 62 | 1 |
| 2 |  | M. Scherzer | 20 | 5/11/2016 |  WSH | vs |  DET | W | 1 | 2.00 | 1 | 0 | 0 | 9.0 | 6 | 2 | 2 | 2 | 0 | 0 | 0 | 0 | 33 | 0 |
| 3 |  | R. Johnson | 20 | 5/8/2001 |  ARI | vs |  CIN | 1 | 1.00 | 0 | 0 | 0 | 9.0 | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 29 | 0 | |
| 4 |  | K. Wood | 20 | 5/6/1998 |  CHC | vs |  HOU | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 29 | 0 |
| 5 |  | R. Clemens | 20 | 9/18/1996 |  BOS | @ | DET | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 32 | 1 |
| 6 | | R. Clemens | 20 | 4/29/1986 | BOS | vs |  SEA | W | 1 | 1.00 | 1 | 0 | 0 | 9.0 | 3 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 30 | 0 |
| 7 |  | R. Johnson | 19 | 8/8/1997 |  SEA | vs |  CWS | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 5 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 35 | 0 |
| 8 | | R. Johnson | 19 | 6/24/1997 | SEA | vs |  OAK | L | 1 | 4.00 | 1 | 0 | 0 | 9.0 | 11 | 4 | 4 | 2 | 0 | 0 | 0 | 0 | 37 | 0 |
| 9 |  | D. Cone | 19 | 10/6/1991 |  NYM | @ |  PHI | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 31 | 0 |
| 10 |  | N. Ryan | 19 | 6/8/1977 |  CAL | vs |  TOR | 1 | 0.00 | 0 | 0 | 0 | 10.0 | 6 | 0 | 1 | 0 | 5 | 0 | 0 | 1 | 41 | 2 | |
| 11 | | N. Ryan | 19 | 8/20/1974 | CAL | vs | DET | L | 1 | 0.82 | 1 | 0 | 0 | 11.0 | 4 | 1 | 1 | 0 | 5 | 0 | 0 | 0 | 41 | 0 |
| 12 | | N. Ryan | 19 | 8/12/1974 | CAL | vs |  BOS | W | 1 | 2.00 | 1 | 0 | 0 | 9.0 | 7 | 2 | 2 | 0 | 2 | 0 | 0 | 0 | 36 | 1 |
| 13 | | N. Ryan | 19 | 6/14/1974 | CAL | vs | BOS | 1 | 2.08 | 0 | 0 | 0 | 13.0 | 8 | 3 | 3 | 1 | 10 | 0 | 0 | 0 | 58 | 0 | |
| 14 |  | T. Seaver | 19 | 4/22/1970 | NYM | vs |  SDP | W | 1 | 1.00 | 1 | 0 | 0 | 9.0 | 2 | 1 | 1 | 1 | 2 | 0 | 0 | 0 | 31 | 0 |
| 15 |  | S. Carlton | 19 | 9/15/1969 |  STL | vs | NYM | L | 1 | 4.00 | 1 | 0 | 0 | 9.0 | 9 | 4 | 4 | 2 | 2 | 0 | 0 | 0 | 38 | 1 |
| 16 |  | L. Tiant | 19 | 7/3/1968 |  CLE | vs |  MIN | W | 1 | 0.00 | 1 | 1 | 0 | 10.0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 36 | 0 |
| 17 |  | C. Kluber | 18 | 5/13/2015 | CLE | vs | STL | W | 1 | 0.00 | 0 | 0 | 0 | 8.0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 26 | 0 |
| 18 |  | B. Sheets | 18 | 5/16/2004 |  MIL | vs |  ATL | W | 1 | 1.00 | 1 | 0 | 0 | 9.0 | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 31 | 0 |
| 19 |  | R. Clemens | 18 | 8/25/1998 |  TOR | vs |  KCR | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 30 | 0 |
| 20 | | R. Johnson | 18 | 9/27/1992 |  SEA | @ |  TEX | 1 | 2.25 | 0 | 0 | 0 | 8.0 | 6 | 2 | 2 | 0 | 4 | 0 | 0 | 0 | 34 | 0 | |
| 21 |  | R. Martinez | 18 | 6/4/1990 |  LAD | vs | ATL | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 31 | 0 |
| 22 |  | B. Gullickson | 18 | 9/10/1980 |  MON | vs | CHC | W | 1 | 2.00 | 1 | 0 | 0 | 9.0 | 4 | 2 | 2 | 0 | 2 | 0 | 0 | 0 | 33 | 1 |
| 23 |  | R. Guidry | 18 | 6/17/1978 |  NYY | vs | CAL | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 4 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 33 | 0 |
| 24 | | N. Ryan | 18 | 9/10/1976 | CAL | @ |  CWS | W | 1 | 2.00 | 1 | 0 | 0 | 9.0 | 3 | 2 | 2 | 0 | 9 | 0 | 0 | 0 | 41 | 0 |
| 25 |  | D. Wilson | 18 | 7/14/1968 |  HOU | @ | CIN | W | 1 | 1.00 | 1 | 0 | 0 | 9.0 | 5 | 1 | 1 | 0 | 2 | 0 | 0 | 0 | 33 | 1 |
Results may be incomplete. StatMuse has complete game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
Astros 
Rangers 
Angels 
PIT 
Rays 
Guardians 
Phillies 
Brewers 
Giants 
AZ 
MIA 
COL 
BOS 
