Max Scherzer has struck out the most hitters by an active pitcher in a game pitched, with 20 strikeouts against the Tigers on May 11, 2016.
Interpreted as:
most strikeouts by a pitcher per regular-season game by active players| NAME | SO | G | DATE | TM | OPP | DEC | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | M. Scherzer | 20 | 1 | 5/11/2016 |  WSH | vs |  DET | W | 1 | 2.00 | 1 | 0 | 0 | 9.0 | 6 | 2 | 2 | 2 | 0 | 0 | 0 | 0 | 33 | 0 |
| 2 |  | C. Sale | 17 | 1 | 5/14/2019 |  BOS | vs |  COL | 1 | 2.57 | 0 | 0 | 0 | 7.0 | 3 | 2 | 2 | 1 | 0 | 0 | 0 | 0 | 24 | 0 | |
| 3 | | M. Scherzer | 17 | 1 | 10/3/2015 | WSH | @ |  NYM | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 28 | 0 |
| 4 |  | S. Strider | 16 | 1 | 9/1/2022 |  ATL | vs | COL | W | 1 | 0.00 | 0 | 0 | 0 | 8.0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 27 | 0 |
| 5 |  | W. Buehler | 16 | 1 | 6/21/2019 |  LAD | vs | COL | W | 1 | 2.00 | 1 | 0 | 0 | 9.0 | 3 | 2 | 2 | 2 | 0 | 0 | 0 | 0 | 30 | 0 |
| 6 |  | G. Cole | 16 | 1 | 5/4/2018 |  HOU | @ |  ARI | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 29 | 0 |
| 7 |  | J. Gray | 16 | 1 | 9/17/2016 | COL | vs |  SDP | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 31 | 0 |
| 8 | | M. Scherzer | 16 | 1 | 6/14/2015 | WSH | @ |  MIL | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 29 | 0 |
| 9 |  | G. Holmes | 15 | 1 | 6/15/2025 | ATL | vs | COL | L | 1 | 2.84 | 0 | 0 | 0 | 6.1 | 3 | 2 | 3 | 1 | 2 | 1 | 0 | 0 | 24 | 0 |
| 10 |  | B. Snell | 15 | 1 | 7/27/2024 |  SFG | vs | COL | 1 | 0.00 | 0 | 0 | 0 | 6.0 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 22 | 1 | |
| 11 |  | G. Cole | 15 | 1 | 9/1/2021 |  NYY | @ |  LAA | W | 1 | 1.29 | 0 | 0 | 0 | 7.0 | 4 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 25 | 0 |
| 12 |  | C. Burnes | 15 | 1 | 8/11/2021 |  MIL | @ |  CHC | W | 1 | 0.00 | 0 | 0 | 0 | 8.0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 27 | 0 |
| 13 |  | J. deGrom | 15 | 1 | 4/23/2021 | NYM | vs | WSH | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 29 | 0 |
| 14 | | G. Cole | 15 | 1 | 9/8/2019 | HOU | vs |  SEA | W | 1 | 1.13 | 0 | 0 | 0 | 8.0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 25 | 0 |
| 15 | | W. Buehler | 15 | 1 | 8/3/2019 | LAD | vs | SDP | W | 1 | 1.00 | 1 | 0 | 0 | 9.0 | 5 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 31 | 1 |
| 16 |  | J. Verlander | 15 | 1 | 6/12/2019 | HOU | vs | MIL | 1 | 3.86 | 0 | 0 | 0 | 7.0 | 4 | 3 | 3 | 3 | 0 | 0 | 0 | 0 | 25 | 0 | |
| 17 | | M. Scherzer | 15 | 1 | 6/2/2019 | WSH | @ |  CIN | W | 1 | 1.13 | 0 | 0 | 0 | 8.0 | 3 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 29 | 0 |
| 18 |  | S. Bieber | 15 | 1 | 5/19/2019 |  CLE | vs |  BAL | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 31 | 0 |
| 19 | | C. Sale | 15 | 1 | 5/11/2018 | BOS | @ |  TOR | 1 | 3.00 | 0 | 0 | 0 | 9.0 | 6 | 3 | 3 | 1 | 0 | 0 | 0 | 0 | 33 | 0 | |
| 20 | | M. Scherzer | 15 | 1 | 5/6/2018 | WSH | vs |  PHI | 1 | 1.42 | 0 | 0 | 0 | 6.1 | 5 | 1 | 1 | 0 | 2 | 1 | 0 | 1 | 26 | 0 | |
| 21 |  | C. Kershaw | 15 | 1 | 9/2/2015 | LAD | vs | SFG | W | 1 | 1.00 | 1 | 0 | 0 | 9.0 | 6 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 32 | 0 |
| 22 |  | C. Sale | 15 | 1 | 8/16/2015 |  CWS | vs | CHC | W | 1 | 0.00 | 0 | 0 | 0 | 7.0 | 1 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 26 | 0 |
| 23 | | C. Kershaw | 15 | 1 | 6/18/2014 | LAD | vs | COL | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 28 | 0 |
| 24 |  | Y. Darvish | 15 | 1 | 8/12/2013 |  TEX | @ | HOU | W | 1 | 1.13 | 0 | 0 | 0 | 8.0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 26 | 0 |
| 25 | | C. Sale | 15 | 1 | 5/28/2012 | CWS | @ |  TBR | W | 1 | 1.23 | 0 | 0 | 0 | 7.1 | 3 | 1 | 1 | 0 | 2 | 0 | 0 | 0 | 27 | 0 |
Results may be incomplete. StatMuse has complete game-level data for games pitched going back to the 1908 season.
Some of the information used here was obtained free of charge from Retrosheet.
Marlins 
SDP 
Guardians 
KCR 
MIN 
PIT 
ATH 
