10 players were tied for the most strikeouts in a game in 2021, with 5 strikeouts. The first three are Matt Chapman on September 24, 2021, Andrew McCutchen on August 21, 2021 and Bo Bichette on August 15, 2021.

Interpreted as:

most strikeouts by a player in a regular-season game in 2021

	NAME	SO	DATE	TM		OPP	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP
1	Matt Chapman M. Chapman	5	9/24/2021	OAK	vs	HOU	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
2	Andrew McCutchen A. McCutchen	5	8/21/2021	PHI	@	SDP	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
3	Bo Bichette B. Bichette	5	8/15/2021	TOR	@	SEA	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
4	Javier Báez J. Báez	5	8/5/2021	NYM	@	MIA	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
5	Ryan McMahon R. McMahon	5	6/25/2021	COL	@	MIL	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
6	Mike Tauchman M. Tauchman	5	6/23/2021	SFG	@	LAA	6	1	1	0	0	1	3	0	0	0	0	6	4	1	0	0	0	0
7	Aaron Judge A. Judge	5	5/5/2021	NYY	vs	HOU	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
8	Daniel Johnson D. Johnson	5	5/2/2021	CLE	@	CWS	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
9	Avisaíl García A. García	5	4/21/2021	MIL	@	SDP	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
10	Yoán Moncada Y. Moncada	5	4/2/2021	CWS	@	LAA	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
11	Ji Man Choi J. Man Choi	4	10/1/2021	TBR	@	NYY	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
12	Bobby Bradley B. Bradley	4	10/1/2021	CLE	@	TEX	5	1	1	0	0	1	1	0	0	0	0	5	4	1	0	0	0	0
13	Miguel Cabrera M. Cabrera	4	10/1/2021	DET	@	CWS	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
14	Josh Rojas J. Rojas	4	10/1/2021	ARI	vs	COL	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
15	Bobby Dalbec B. Dalbec	4	9/26/2021	BOS	vs	NYY	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
16	Francisco Lindor F. Lindor	4	9/25/2021	NYM	@	MIL	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
17	Wil Myers W. Myers	4	9/25/2021	SDP	vs	ATL	5	1	1	0	0	0	0	0	0	0	0	5	1	0	0	0	0	0
18	Bo Bichette B. Bichette	4	9/24/2021	TOR	@	MIN	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
19	Patrick Wisdom P. Wisdom	4	9/22/2021	CHC	vs	MIN	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
20	Jorge Polanco J. Polanco	4	9/21/2021	MIN	@	CHC	6	0	0	0	0	0	0	0	0	0	0	6	0	0	0	0	0	0
21	Jonah Heim J. Heim	4	9/20/2021	TEX	@	NYY	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
22	Bobby Bradley B. Bradley	4	9/19/2021	CLE	@	NYY	5	0	1	0	0	0	0	0	0	0	0	5	1	0	0	0	0	0
23	Patrick Wisdom P. Wisdom	4	9/19/2021	CHC	@	MIL	5	1	1	0	0	1	3	0	0	0	0	5	4	1	0	0	0	0
24	Salvador Perez S. Perez	4	9/18/2021	KCR	vs	SEA	5	0	1	0	0	0	1	0	0	0	0	5	1	0	0	0	0	0
25	Patrick Wisdom P. Wisdom	4	9/18/2021	CHC	@	MIL	4	0	0	0	0	0	0	1	0	0	0	5	0	0	0	0	0	0