Tom Cheney has struck out the most hitters in a game, with 21 strikeouts versus the Orioles on September 12, 1962.
- Regular season
| NAME | SO | DATE | TM | OPP | DEC | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | T. Cheney | 21 | 9/12/1962 | @ | W | 1 | 0.56 | 1 | 0 | 0 | 16.0 | 10 | 1 | 1 | 0 | 4 | 0 | 0 | 0 | 62 | 1 | ||
| 2 |  | M. Scherzer | 20 | 5/11/2016 | vs | W | 1 | 2.00 | 1 | 0 | 0 | 9.0 | 6 | 2 | 2 | 2 | 0 | 0 | 0 | 0 | 33 | 0 | ||
| 3 |  | R. Johnson | 20 | 5/8/2001 | vs | 1 | 1.00 | 0 | 0 | 0 | 9.0 | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 29 | 0 | |||
| 4 | | K. Wood | 20 | 5/6/1998 | vs | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 29 | 0 | ||
| 5 |  | R. Clemens | 20 | 9/18/1996 | @ | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 32 | 1 | ||
| 6 | | R. Clemens | 20 | 4/29/1986 | vs | W | 1 | 1.00 | 1 | 0 | 0 | 9.0 | 3 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 30 | 0 | ||
| 7 |  | R. Johnson | 19 | 8/8/1997 | vs | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 5 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 35 | 0 | ||
| 8 | | R. Johnson | 19 | 6/24/1997 | vs | L | 1 | 4.00 | 1 | 0 | 0 | 9.0 | 11 | 4 | 4 | 2 | 0 | 0 | 0 | 0 | 37 | 0 | ||
| 9 | | D. Cone | 19 | 10/6/1991 | @ | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 31 | 0 | ||
| 10 |  | N. Ryan | 19 | 6/8/1977 | vs | 1 | 0.00 | 0 | 0 | 0 | 10.0 | 6 | 0 | 1 | 0 | 5 | 0 | 0 | 1 | 41 | 2 | |||
| 11 | | N. Ryan | 19 | 8/20/1974 | vs | L | 1 | 0.82 | 1 | 0 | 0 | 11.0 | 4 | 1 | 1 | 0 | 5 | 0 | 0 | 0 | 41 | 0 | ||
| 12 | | N. Ryan | 19 | 8/12/1974 | vs | W | 1 | 2.00 | 1 | 0 | 0 | 9.0 | 7 | 2 | 2 | 0 | 2 | 0 | 0 | 0 | 36 | 1 | ||
| 13 | | N. Ryan | 19 | 6/14/1974 | vs | 1 | 2.08 | 0 | 0 | 0 | 13.0 | 8 | 3 | 3 | 1 | 10 | 0 | 0 | 0 | 58 | 0 | |||
| 14 |  | T. Seaver | 19 | 4/22/1970 | vs | W | 1 | 1.00 | 1 | 0 | 0 | 9.0 | 2 | 1 | 1 | 1 | 2 | 0 | 0 | 0 | 31 | 0 | ||
| 15 |  | S. Carlton | 19 | 9/15/1969 | vs | L | 1 | 4.00 | 1 | 0 | 0 | 9.0 | 9 | 4 | 4 | 2 | 2 | 0 | 0 | 0 | 38 | 1 | ||
| 16 | | L. Tiant | 19 | 7/3/1968 | vs | W | 1 | 0.00 | 1 | 1 | 0 | 10.0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 36 | 0 | ||
| 17 |  | C. Kluber | 18 | 5/13/2015 | vs | W | 1 | 0.00 | 0 | 0 | 0 | 8.0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 26 | 0 | ||
| 18 | | B. Sheets | 18 | 5/16/2004 | vs | W | 1 | 1.00 | 1 | 0 | 0 | 9.0 | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 31 | 0 | ||
| 19 |  | R. Clemens | 18 | 8/25/1998 | vs | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 30 | 0 | ||
| 20 | | R. Johnson | 18 | 9/27/1992 | @ | 1 | 2.25 | 0 | 0 | 0 | 8.0 | 6 | 2 | 2 | 0 | 4 | 0 | 0 | 0 | 34 | 0 | |||
| 21 | | R. Martinez | 18 | 6/4/1990 | vs | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 31 | 0 | ||
| 22 | | B. Gullickson | 18 | 9/10/1980 | vs | W | 1 | 2.00 | 1 | 0 | 0 | 9.0 | 4 | 2 | 2 | 0 | 2 | 0 | 0 | 0 | 33 | 1 | ||
| 23 | | R. Guidry | 18 | 6/17/1978 | vs | W | 1 | 0.00 | 1 | 1 | 0 | 9.0 | 4 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 33 | 0 | ||
| 24 | | N. Ryan | 18 | 9/10/1976 | @ | W | 1 | 2.00 | 1 | 0 | 0 | 9.0 | 3 | 2 | 2 | 0 | 9 | 0 | 0 | 0 | 41 | 0 | ||
| 25 | | D. Wilson | 18 | 7/14/1968 | @ | W | 1 | 1.00 | 1 | 0 | 0 | 9.0 | 5 | 1 | 1 | 0 | 2 | 0 | 0 | 0 | 33 | 1 | ||
WSH
BAL
WSH
DET
ARI
CIN
CHC
HOU
BOS
SEA
SEA
CWS
OAK
NYM
PHI
CAL
TOR
BOS
SDP
STL
CLE
MIN
MIL
ATL
TOR
KCR
SEA
TEX
MON
NYY
CWS
HOUResults may be incomplete. StatMuse has complete game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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89 | 63 | .586 | ||
83 | 68 | .550 | 5.5 | |
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| NL West | W | L | PCT | GB |
 Dodgers - x | 92 | 59 | .609 | |
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