Mickey Mantle has the most career strikeouts versus the Cleveland Indians, with 262 strikeouts.

Interpreted as:

most strikeouts by a player vs guardians career

	NAME	SO	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Mickey Mantle M. Mantle	262	316	1,059	208	290	34	5	65	183	246	0	13	5	1,313	529	104	0	8	21	15	.274	.408	.500	.908
2	Reggie Jackson R. Jackson	216	229	787	132	200	35	7	42	139	114	9	14	5	917	375	84	2	5	18	12	.254	.353	.476	.829
3	Jimmie Foxx J. Foxx	209	323	1,146	239	357	74	16	67	271	191	3	10		1,356	664	157	16			7	.312	.411	.579	.991
4	Alex Gordon A. Gordon	195	206	746	91	183	33	4	19	73	80	13	11	8	844	281	56	2	3	7	13	.245	.328	.377	.704
5	Miguel Cabrera M. Cabrera	189	252	932	139	287	44	0	50	177	115	7	5	1	1,068	481	94	0	14	24	29	.308	.383	.516	.899
6	Harmon Killebrew H. Killebrew	181	246	816	112	199	19	4	56	145	119	5	2	0	944	394	79	0	4	12	21	.244	.342	.483	.825
7	George Scott G. Scott	180	219	799	98	215	34	4	34	126	92	10	7	8	909	359	72	3	5	11	37	.269	.350	.449	.799
8	Babe Ruth B. Ruth	173	356	1,133	297	404	69	17	92	278	346	6	12		1,498	783	178	13				.357	.509	.691	1.200
9	José Abreu J. Abreu	163	156	596	71	149	32	2	29	91	44	14	0	0	660	272	63	0	6	9	17	.250	.314	.456	.770
10	Carl Yastrzemski C. Yastrzemski	162	343	1,259	198	351	83	6	51	205	200	4	17	14	1,476	599	140	1	12	24	42	.279	.376	.476	.852
11	Salvador Perez S. Perez	161	168	630	63	154	33	1	24	86	24	10	0	0	668	261	58	0	4	1	14	.244	.281	.414	.696
12	Rudy York R. York	161	237	877	108	200	35	8	29	137	110	1	7		992	338	72	4			30	.228	.315	.385	.700
13	Paul Konerko P. Konerko	159	243	903	124	247	47	1	48	177	101	10	1	0	1,024	440	96	0	10	15	27	.274	.350	.487	.837
14	Dwight Evans D. Evans	154	231	778	143	213	43	6	37	118	128	9	6	4	923	379	86	3	5	5	16	.274	.380	.487	.868
15	Torii Hunter T. Hunter	151	212	812	114	223	48	2	37	131	59	9	17	8	884	386	87	0	4	1	27	.275	.329	.475	.805
16	Al Kaline A. Kaline	149	332	1,197	166	343	45	10	44	197	150	3	20	10	1,368	540	99	6	12	15	36	.287	.364	.451	.815
17	Eddie Yost E. Yost	149	291	1,017	162	244	40	8	17	98	222	13	10	6	1,274	351	65	18	4	2	17	.240	.381	.345	.727
18	Jose Canseco J. Canseco	146	156	611	105	166	29	2	35	125	67	4	14	11	694	304	66	0	12	3	17	.272	.341	.498	.839
19	Miguel Sanó M. Sanó	145	95	335	42	70	19	0	20	43	54	1	2	0	390	149	39	0	0	2	7	.209	.321	.445	.765
20	Jim Rice J. Rice	145	194	781	126	247	40	10	37	172	54	4	9	7	848	418	87	0	9	4	27	.316	.360	.535	.895
21	Willie Horton W. Horton	145	204	733	87	194	21	5	35	118	60	3	1	5	803	330	61	2	5	11	24	.265	.321	.450	.771
22	Bobby Grich B. Grich	140	183	634	80	160	22	4	14	81	107	7	10	7	759	232	40	4	7	4	14	.252	.363	.366	.729
23	Gus Zernial G. Zernial	139	186	631	76	143	18	2	28	84	54	2	4	1	692	249	48	1	4	1	16	.227	.288	.395	.683
24	Bob Johnson B. Johnson	138	265	970	155	281	59	16	31	165	163	3	18		1,139	465	106	3			16	.290	.393	.479	.873
25	Adam Dunn A. Dunn	136	100	356	47	85	18	0	20	62	61	6	0	2	425	163	38	0	2	0	4	.239	.358	.458	.816

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StatMuse has game-level data for strikeouts going back to the 1916 season.

Some of the information used here was obtained free of charge from Retrosheet.

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Interpreted as:

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