The New York Yankees had their most runs in a game against the Philadelphia Athletics on May 24, 1936, with 25 runs.

Interpreted as:

most yankees runs in a regular-season game in a series

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	25	5/24/1936	NYY	@	PHA	W 25-2	45	19	3	3	6	25	16	0	5	0	0	61	46	12	0				.422	.574	1.022	1.596
2	Yankees	24	9/28/1923	NYY	@	BSA	W 24-4	55	30	8	0	2	21	6	0	7	2	0	62	44	10	1				.545	.590	.800	1.390
3	Yankees	23	6/28/1939	NYY	@	PHA	W 23-2	56	27	2	0	8	22	5	0	1	3	0	61	53	10	0			0	.482	.525	.946	1.471
4	Yankees	22	8/25/2011	NYY	vs	OAK	W 22-9	43	21	2	1	5	22	13	1	9	0	0	58	40	8	0	1	1	0	.488	.603	.930	1.534
5	Yankees	22	6/19/2000	NYY	@	BOS	W 22-1	47	19	4	1	5	21	7	0	4	1	0	55	40	10	0	1	1	0	.404	.473	.851	1.324
6	Yankees	22	8/12/1953	NYY	@	WSH	W 22-1	52	28	3	2	1	22	7	0	2	0	0	61	38	6	2		0	0	.538	.593	.731	1.324
7	Yankees	22	5/2/1939	NYY	@	DET	W 22-2	43	17	4	1	4	21	12	0	3	0	0	56	35	9	1			0	.395	.527	.814	1.341
8	Yankees	22	7/26/1931	NYY	vs	CWS	W 22-5	39	17	1	0	0	21	12	0	2	3	0	52	18	1	1				.436	.569	.462	1.030
9	Yankees	21	7/28/2015	NYY	@	TEX	W 21-5	46	19	5	1	2	20	10	2	11	0	0	58	32	8	0	0	0	1	.413	.534	.696	1.230
10	Yankees	21	7/22/2007	NYY	vs	TBD	W 21-4	48	25	4	1	6	20	7	1	8	3	0	56	49	11	0	0	0	1	.521	.589	1.021	1.610
11	Yankees	21	8/23/1999	NYY	@	TEX	W 21-3	50	23	7	1	2	21	5	0	6	1	0	55	38	10	0	0	0	0	.460	.509	.760	1.269
12	Yankees	21	7/24/1999	NYY	vs	CLE	W 21-1	44	21	5	0	2	21	9	0	7	0	0	54	32	7	0	1	1	0	.477	.556	.727	1.283
13	Yankees	21	8/19/1962	NYY	@	KCA	W 21-7	46	20	4	2	4	21	5	1	2	3	0	53	40	10	1	0	0	0	.435	.500	.870	1.370
14	Yankees	21	8/13/1939	NYY	@	PHA	W 21-0	47	23	2	1	4	21	6	1	1	1	0	55	39	7	1			0	.489	.556	.830	1.385
15	Yankees	21	7/4/1927	NYY	vs	WSH	W 21-1	41	19	5	3	3	20	11	0	2	0	0	54	39	11	2				.463	.577	.951	1.528
16	Yankees	21	9/25/1921	NYY	vs	CLE	W 21-7	44	20	1	2	2	19	8	0	3	1	0	52	31	5	0				.455	.538	.705	1.243
17	Highlanders	21	7/14/1904	NYH	vs	CLE	W 21-3	50	21	4	2	2	15	1	0	3	2		52	35	8	1				.420	.431	.700	1.131
18	Yankees	20	3/29/2025	NYY	vs	MIL	W 20-9	40	16	2	0	9	20	8	2	5	0	0	51	45	11	0	1	0	0	.400	.510	1.125	1.635
19	Yankees	20	9/15/2020	NYY	vs	TOR	W 20-6	41	16	5	0	6	20	7	2	9	0	0	50	39	11	0	0	0	0	.390	.500	.951	1.451
20	Yankees	20	8/30/2015	NYY	@	ATL	W 20-6	46	21	3	0	3	20	9	1	7	0	0	57	33	6	0	1	0	1	.457	.544	.717	1.261
21	Yankees	20	8/21/2009	NYY	@	BOS	W 20-11	49	23	8	1	2	20	5	0	5	0	0	54	39	11	0	0	0	1	.469	.519	.796	1.314
22	Yankees	20	6/21/2005	NYY	vs	TBD	W 20-11	46	23	4	1	6	20	4	0	5	0	0	51	47	11	0	1	1	0	.500	.529	1.022	1.551
23	Yankees	20	6/19/2002	NYY	@	COL	W 20-10	45	18	7	0	3	19	8	3	7	2	0	58	34	10	0	2	2	0	.400	.500	.756	1.256
24	Yankees	20	8/14/1955	NYY	@	BAL	W 20-6	46	20	6	0	2	20	11	1	4	0	0	59	32	8	0	1	0	0	.435	.542	.696	1.238
25	Yankees	20	9/11/1949	NYY	vs	WSH	W 20-5	39	17	3	1	0	19	17	0	4	1	0	56	22	4	0			1	.436	.607	.564	1.171