The New York Mets had their lowest run differential in a game against the Nationals on July 31, 2018, with a differential of -21 runs.

Interpreted as:

new york mets lowest run diff in a regular-season game

	TEAM	DIFF	DATE	TM		OPP	RESULT	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Mets	-21	7/31/2018	NYM	@	WSH	L 4-25	36	4	9	2	0	2	4	1	0	10	0	1	37	17	4	0	0	0	0	.250	.270	.472	.742
2	Mets	-19	6/11/1985	NYM	@	PHI	L 7-26	36	7	13	3	0	0	7	3	0	6	0	1	41	16	3	0	2	0	1	.361	.390	.444	.835
3	Mets	-18	8/12/2023	NYM	vs	ATL	L 3-21	33	3	6	1	0	1	3	4	1	9	0	0	38	10	2	0	0	1	0	.182	.289	.303	.593
4	Mets	-18	6/30/2021	NYM	@	ATL	L 2-20	30	2	4	1	0	1	2	3	0	12	0	0	33	8	2	0	0	0	1	.133	.212	.267	.479
5	Mets	-18	4/30/2017	NYM	@	WSH	L 5-23	36	5	9	2	1	2	5	2	0	12	0	0	38	19	5	0	0	0	0	.250	.289	.528	.817
6	Mets	-17	9/26/1992	NYM	@	PIT	L 2-19	36	2	10	3	0	0	2	3	1	5	2	0	40	13	3	0	0	0	1	.278	.350	.361	.711
7	Mets	-16	7/2/1999	NYM	vs	ATL	L 0-16	30	0	3	0	0	0	0	2	0	2	1	0	32	3	0	0	0	0	1	.100	.156	.100	.256
8	Mets	-16	6/16/1966	NYM	@	ATL	L 1-17	32	1	5	0	0	1	1	3	0	4	0	0	35	8	1	0	0	0	0	.156	.229	.250	.479
9	Mets	-15	8/26/2018	NYM	vs	WSH	L 0-15	30	0	3	0	0	0	0	5	0	7	0	0	35	3	0	0	0	0	0	.100	.229	.100	.329
10	Mets	-15	9/20/2012	NYM	vs	PHI	L 1-16	27	1	3	0	0	1	1	3	0	6	0	0	30	6	1	0	0	0	3	.111	.200	.222	.422
11	Mets	-15	6/14/2009	NYM	@	NYY	L 0-15	31	0	6	0	0	0	0	4	0	12	0	0	35	6	0	0	0	0	2	.194	.286	.194	.479
12	Mets	-15	8/22/2000	NYM	@	SDP	L 1-16	31	1	7	1	0	0	1	3	0	7	2	0	34	8	1	0	0	0	1	.226	.294	.258	.552
13	Mets	-14	6/30/1997	NYM	@	DET	L 0-14	30	0	5	1	0	0	0	4	0	5	0	0	34	6	1	0	0	0	2	.167	.265	.200	.465
14	Mets	-14	7/14/1962	NYM	vs	LAD	L 3-17	32	3	6	1	0	1	3	2	0	3	1	0	34	10	2	0	0	0	2	.188	.235	.313	.548
15	Mets	-14	7/8/1962	NYM	vs	STL	L 1-15	30	1	3	0	1	0	1	6	1	4	0	0	37	5	1	0	0	0	0	.100	.270	.167	.437
16	Mets	-13	9/18/2020	NYM	vs	ATL	L 2-15	31	2	5	1	0	0	2	6	2	7	0	0	39	6	1	0	0	0	1	.161	.333	.194	.527
17	Mets	-13	7/26/2020	NYM	vs	ATL	L 1-14	33	1	6	2	0	0	1	3	2	6	0	0	38	8	2	0	0	0	0	.182	.289	.242	.532
18	Mets	-13	7/28/2013	NYM	@	WSH	L 1-14	35	1	8	1	0	0	1	4	0	9	0	0	39	9	1	0	0	0	0	.229	.308	.257	.565
19	Mets	-13	8/8/2012	NYM	vs	MIA	L 0-13	31	0	5	1	0	0	0	6	0	3	0	0	37	6	1	0	0	0	1	.161	.297	.194	.491
20	Mets	-13	8/1/2010	NYM	vs	ARI	L 1-14	31	1	5	1	0	0	1	1	0	5	0	0	33	6	1	0	1	0	0	.161	.182	.194	.375
21	Mets	-13	8/19/2009	NYM	vs	ATL	L 2-15	35	2	10	2	1	0	2	2	0	7	0	1	37	14	3	0	0	0	1	.286	.324	.400	.724
22	Mets	-13	8/14/2006	NYM	@	PHI	L 0-13	31	0	4	1	0	0	0	0	0	10	0	0	31	5	1	0	0	0	0	.129	.129	.161	.290
23	Mets	-13	3/31/2003	NYM	vs	CHC	L 2-15	31	2	4	2	0	0	2	3	1	12	0	0	35	6	2	0	0	0	0	.129	.229	.194	.422
24	Mets	-13	7/30/2002	NYM	vs	HOU	L 3-16	33	3	8	1	0	2	3	1	0	2	0	0	34	15	3	0	0	0	2	.242	.265	.455	.719
25	Mets	-13	5/10/1979	NYM	@	LAD	L 1-14	30	1	6	1	0	1	1	3	0	4	1	0	33	10	2	0	0	0	1	.200	.273	.333	.606