The Kansas City Royals had their highest run differential in a game against the Tigers on September 9, 2004, with a differential of 21 runs.

Interpreted as:

royals biggest win margin in a regular-season game

	TEAM	DIFF	DATE	TM		OPP	RESULT	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Royals	21	9/9/2004	KCR	@	DET	W 26-5	52	26	26	5	1	1	25	8	0	6	0	0	62	36	7	0	2	0	0	.500	.548	.692	1.241
2	Royals	19	9/19/2025	KCR	vs	TOR	W 20-1	51	20	27	7	0	3	20	5	0	6	1	0	56	43	10	0	0	0	0	.529	.571	.843	1.415
3	Royals	17	4/6/1974	KCR	vs	MIN	W 23-6	42	23	16	5	0	2	21	9	1	5	2	0	52	27	7	0	0	0	0	.381	.500	.643	1.143
4	Royals	16	6/25/1984	KCR	vs	OAK	W 16-0	42	16	17	5	0	2	15	1	0	1	0	0	44	28	7	0	1	0	0	.405	.409	.667	1.076
5	Royals	16	10/4/1980	KCR	vs	MIN	W 17-1	41	17	18	2	0	1	16	5	0	3	2	0	48	23	3	0	2	0	0	.439	.479	.561	1.040
6	Royals	15	9/24/2002	KCR	vs	DET	W 17-2	40	17	15	2	0	3	16	5	1	6	0	0	47	26	5	0	1	0	0	.375	.447	.650	1.097
7	Royals	15	8/10/1996	KCR	@	CAL	W 18-3	41	18	15	0	0	3	18	8	3	1	0	0	53	24	3	0	1	0	0	.366	.491	.585	1.076
8	Royals	15	4/24/1977	KCR	@	SEA	W 16-1	41	16	16	3	0	1	14	5	1	6	1	0	48	22	4	0	1	0	1	.390	.458	.537	.995
9	Royals	15	5/19/1972	KCR	vs	OAK	W 16-1	42	16	20	3	0	4	15	3	0	5	0	0	47	35	7	0	2	0	1	.476	.489	.833	1.323
10	Royals	14	7/26/2017	KCR	@	DET	W 16-2	47	16	22	2	0	1	16	4	3	7	2	1	55	27	3	0	1	0	0	.468	.527	.574	1.102
11	Royals	14	7/3/2007	KCR	vs	SEA	W 17-3	39	17	16	2	0	2	16	4	3	4	1	0	49	24	4	0	3	0	0	.410	.469	.615	1.085
12	Royals	14	7/14/1991	KCR	@	DET	W 18-4	48	18	21	1	0	6	18	3	1	6	0	0	52	40	7	0	0	0	0	.438	.481	.833	1.314
13	Royals	14	5/11/1982	KCR	vs	MIL	W 17-3	43	17	21	6	0	3	17	4	0	2	0	0	48	36	9	1	0	0	1	.488	.532	.837	1.369
14	Royals	14	4/9/1977	KCR	@	DET	W 16-2	42	16	16	3	1	2	16	8	0	4	1	0	51	27	6	0	1	0	1	.381	.471	.643	1.113
15	Royals	14	6/15/1976	KCR	@	DET	W 21-7	48	21	24	4	1	2	20	4	0	5	0	0	53	36	7	0	1	0	0	.500	.528	.750	1.278
16	Royals	14	8/6/1974	KCR	vs	MIN	W 17-3	45	17	20	3	1	1	16	5	1	2	0	0	52	28	5	1	0	0	0	.444	.510	.622	1.132
17	Royals	14	5/4/1969	KCR	@	CAL	W 15-1	44	15	19	2	0	3	13	8	0	5	1	1	53	30	5	0	1	0	0	.432	.509	.682	1.191
18	Royals	13	8/5/2013	KCR	vs	MIN	W 13-0	39	13	16	3	0	1	13	4	0	6	0	0	43	22	4	0	0	0	1	.410	.465	.564	1.029
19	Royals	13	4/17/2002	KCR	@	MIN	W 16-3	41	16	16	4	0	1	16	7	0	5	0	1	49	23	5	0	1	0	0	.390	.469	.561	1.030
20	Royals	13	6/3/2000	KCR	@	PIT	W 16-3	43	16	18	2	1	3	14	8	1	7	0	0	53	31	6	0	1	0	2	.419	.509	.721	1.230
21	Royals	13	6/27/1997	KCR	vs	MIL	W 16-3	40	16	15	1	1	3	14	4	0	6	1	0	44	27	5	0	0	0	0	.375	.432	.675	1.107
22	Royals	13	8/16/1992	KCR	vs	BAL	W 15-2	38	15	17	3	0	2	14	5	1	8	2	0	46	26	5	1	1	0	1	.447	.511	.684	1.195
23	Royals	13	6/19/1991	KCR	@	TEX	W 15-2	42	15	20	4	0	2	15	9	0	8	0	0	52	30	6	0	1	0	3	.476	.558	.714	1.272
24	Royals	13	5/19/1988	KCR	@	MIN	W 14-1	44	14	18	5	1	4	14	7	0	8	1	0	51	37	10	0	0	0	1	.409	.490	.841	1.331
25	Royals	13	5/16/1987	KCR	vs	MIL	W 13-0	38	13	15	3	1	1	13	5	0	5	0	0	43	23	5	0	0	0	0	.395	.465	.605	1.070