The Philadelphia Phillies and the Cleveland Indians were tied for the most runs in a game in 2009, with 22 runs.

Interpreted as:

team most runs in a regular-season game 2009

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Phillies	22	7/6/2009	PHI	vs	CIN	W 22-1	43	21	6	0	4	21	7	1	9	0	0	52	39	10	0	1	0	1	.488	.558	.907	1.465
2	Indians	22	4/18/2009	CLE	@	NYY	W 22-4	52	25	7	0	6	22	6	0	10	0	0	58	50	13	0	0	0	0	.481	.534	.962	1.496
3	Yankees	20	8/21/2009	NYY	@	BOS	W 20-11	49	23	8	1	2	20	5	0	5	0	0	54	39	11	0	0	0	1	.469	.519	.796	1.314
4	Twins	20	5/21/2009	MIN	@	CWS	W 20-1	46	20	4	0	4	18	5	1	5	0	0	54	36	8	1	1	1	0	.435	.491	.783	1.273
5	Rangers	19	4/15/2009	TEX	vs	BAL	W 19-6	44	19	5	2	2	18	7	1	7	3	0	53	34	9	0	1	1	0	.432	.509	.773	1.282
6	Blue Jays	18	8/31/2009	TOR	@	TEX	W 18-10	39	14	4	1	4	18	7	2	8	0	2	49	32	9	0	1	0	0	.359	.469	.821	1.290
7	Red Sox	18	8/2/2009	BOS	@	BAL	W 18-10	48	23	3	0	2	17	7	0	3	0	0	55	32	5	0	0	0	2	.479	.545	.667	1.212
8	Angels	17	8/16/2009	LAA	@	BAL	W 17-8	59	23	6	0	2	17	6	1	7	5	0	68	35	8	0	2	1	1	.390	.441	.593	1.034
9	Cubs	17	8/14/2009	CHC	vs	PIT	W 17-2	41	18	5	2	1	17	6	1	5	0	0	48	30	8	0	0	0	1	.439	.521	.732	1.253
10	Dodgers	17	8/4/2009	LAD	vs	MIL	W 17-4	41	18	6	0	2	17	5	2	10	0	0	49	30	8	1	0	0	0	.439	.521	.732	1.253
11	White Sox	17	5/25/2009	CWS	@	LAA	W 17-3	51	24	4	0	3	17	4	1	8	1	0	56	37	7	0	0	0	0	.471	.518	.725	1.243
12	Orioles	16	8/14/2009	BAL	vs	LAA	W 16-6	41	19	9	2	1	16	5	1	6	0	0	48	35	12	0	1	1	0	.463	.521	.854	1.374
13	Athletics	16	7/22/2009	OAK	vs	MIN	W 16-1	41	18	0	1	1	15	8	0	1	0	0	49	23	2	0	0	0	2	.439	.531	.561	1.092
14	Dodgers	16	5/25/2009	LAD	@	COL	W 16-6	45	19	2	1	0	16	4	0	11	2	0	51	23	3	1	1	0	0	.422	.460	.511	.971
15	Red Sox	16	4/25/2009	BOS	vs	NYY	W 16-11	33	13	5	0	3	16	7	2	6	1	0	43	27	8	0	1	2	2	.394	.512	.818	1.330
16	Athletics	15	9/26/2009	OAK	@	LAA	W 15-10	44	19	5	0	3	14	5	0	7	1	0	50	33	8	0	1	0	0	.432	.480	.750	1.230
17	Rangers	15	9/26/2009	TEX	vs	TBR	W 15-3	44	19	5	0	3	15	5	0	12	0	0	49	33	8	0	0	0	0	.432	.490	.750	1.240
18	Nationals	15	8/25/2009	WSH	@	CHC	W 15-6	37	14	2	0	3	15	6	1	8	0	1	45	25	5	0	1	1	2	.378	.467	.676	1.142
19	Braves	15	8/19/2009	ATL	@	NYM	W 15-2	45	18	3	0	3	14	2	1	4	0	0	49	30	6	1	0	0	0	.400	.438	.667	1.104
20	Red Sox	15	7/11/2009	BOS	vs	KCR	W 15-9	36	12	3	1	4	13	9	1	11	2	0	47	29	8	0	1	3	0	.333	.468	.806	1.274
21	Indians	15	7/3/2009	CLE	vs	OAK	W 15-3	40	15	5	0	3	13	7	0	6	2	0	47	29	8	0	0	0	1	.375	.468	.725	1.193
22	Yankees	15	6/14/2009	NYY	vs	NYM	W 15-0	37	17	5	0	2	14	7	1	6	0	0	46	28	7	0	1	0	1	.459	.543	.757	1.300
23	Rays	15	5/22/2009	TBR	@	FLA	W 15-2	44	17	3	0	3	15	9	1	9	1	0	54	29	6	0	0	0	1	.386	.500	.659	1.159
24	Astros	15	5/13/2009	HOU	@	COL	W 15-11	51	24	6	0	0	15	3	0	6	1	0	54	30	6	0	0	0	0	.471	.500	.588	1.088
25	Brewers	15	5/6/2009	MIL	@	CIN	W 15-3	44	20	3	0	3	15	5	0	8	0	0	50	32	6	0	1	0	2	.455	.500	.727	1.227