Since 2010, the Colorado Rockies have lost the most games by a team, with 1,355 losses.

Interpreted as:

teams with the most regular-season losses since 2010

	TEAM	L	W	L%	G	W%	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rockies	1,355	1,059	.561	2,414	.439	82,590	11,163	21,543	4,287	605	2,681	10,677	7,044	693	20,336	1,273	512	91,613	35,083	7,573	685	601	476	1,765	.261	.322	.425	.747
2	Marlins	1,352	1,058	.561	2,410	.439	81,657	9,492	20,210	3,755	436	2,123	9,030	6,798	822	19,892	1,403	484	90,486	31,206	6,314	660	549	449	1,835	.247	.310	.382	.692
3	White Sox	1,331	1,082	.552	2,413	.448	81,963	10,018	20,501	3,831	341	2,504	9,580	6,497	937	19,538	1,286	537	90,359	32,526	6,676	413	549	271	1,818	.250	.311	.397	.707
4	Royals	1,310	1,105	.542	2,415	.458	82,283	10,083	21,111	4,091	507	2,144	9,604	6,260	777	17,284	1,896	585	90,449	32,648	6,742	448	681	322	1,792	.257	.313	.397	.710
5	Pirates	1,290	1,124	.534	2,415	.466	81,368	9,794	19,950	3,942	467	2,205	9,351	7,322	926	19,831	1,338	577	90,829	31,441	6,614	641	572	460	1,695	.245	.313	.386	.699
6	Orioles	1,270	1,144	.526	2,414	.474	82,493	10,591	20,673	3,990	276	3,026	10,148	6,669	850	19,658	1,037	375	90,896	34,293	7,292	308	576	289	1,783	.251	.311	.416	.727
7	Reds	1,260	1,155	.522	2,415	.478	81,475	10,556	20,218	3,924	380	2,712	10,075	7,688	1,064	20,014	1,602	588	91,513	33,038	7,016	703	583	457	1,667	.248	.319	.405	.725
8	Diamondbacks	1,254	1,160	.519	2,414	.481	82,238	10,999	20,635	4,264	581	2,605	10,471	7,870	817	19,821	1,515	492	92,187	33,876	7,450	604	658	508	1,690	.251	.320	.412	.732
9	Twins	1,252	1,162	.519	2,414	.481	82,349	10,912	20,723	4,262	386	2,699	10,402	7,731	887	19,495	1,076	414	91,889	33,854	7,347	311	611	343	1,730	.252	.320	.411	.731
10	Padres	1,249	1,165	.517	2,414	.483	80,803	9,924	19,530	3,753	406	2,390	9,431	7,574	772	19,897	1,648	538	90,390	31,265	6,549	651	590	442	1,646	.242	.311	.387	.698
11	Tigers	1,244	1,166	.516	2,410	.484	82,293	10,488	21,113	4,087	515	2,436	10,053	7,100	730	19,602	996	407	91,069	33,538	7,038	308	638	401	1,839	.257	.319	.408	.726
12	Athletics	1,241	1,176	.513	2,417	.487	81,585	10,443	19,757	4,057	369	2,667	9,937	7,849	870	19,308	1,309	392	91,208	32,553	7,093	292	612	275	1,806	.242	.313	.399	.712
13	Angels	1,237	1,176	.513	2,413	.487	81,618	10,579	20,280	3,873	356	2,754	10,083	7,290	925	18,864	1,370	524	90,835	33,127	6,983	391	611	437	1,844	.248	.315	.406	.721
14	Mariners	1,231	1,183	.510	2,414	.490	81,474	10,022	19,579	3,699	294	2,682	9,576	7,528	976	20,416	1,458	518	90,877	31,912	6,675	346	553	327	1,629	.240	.310	.392	.702
15	Rangers	1,212	1,204	.502	2,416	.498	82,161	11,129	20,834	3,952	358	2,824	10,570	7,312	917	19,044	1,666	582	91,434	33,974	7,134	401	643	358	1,654	.254	.319	.414	.733
16	Nationals	1,210	1,203	.501	2,413	.499	81,523	10,638	20,689	4,082	365	2,582	10,121	7,603	906	18,882	1,620	520	91,346	33,247	7,029	691	623	513	1,756	.254	.322	.408	.730
17	Mets	1,205	1,210	.499	2,415	.501	81,629	10,384	20,173	4,007	367	2,627	9,965	7,762	1,102	19,250	1,258	423	91,625	32,795	7,001	559	573	515	1,743	.247	.319	.402	.721
18	Cubs	1,201	1,213	.498	2,415	.502	81,622	10,707	20,190	4,055	439	2,713	10,194	7,889	1,084	20,520	1,286	501	91,703	33,262	7,207	553	555	481	1,687	.247	.320	.408	.727
19	Phillies	1,195	1,220	.495	2,415	.505	82,094	10,541	20,461	3,985	452	2,603	10,068	7,488	881	19,515	1,474	396	91,589	33,159	7,040	579	547	524	1,655	.249	.317	.404	.721
20	Blue Jays	1,194	1,220	.495	2,414	.505	82,018	11,160	20,634	4,259	280	3,125	10,671	7,782	799	18,697	1,193	422	91,501	34,828	7,664	311	591	285	1,869	.252	.320	.425	.745
21	Giants	1,172	1,243	.485	2,415	.515	82,000	10,155	20,429	4,088	480	2,256	9,672	7,447	792	19,109	1,072	436	91,485	32,245	6,824	584	662	504	1,823	.249	.315	.393	.709
22	Astros	1,164	1,249	.482	2,413	.518	82,011	10,921	20,872	4,170	321	2,828	10,412	7,493	870	18,744	1,419	524	91,410	34,168	7,319	412	624	340	1,884	.255	.321	.417	.738
23	Red Sox	1,148	1,268	.475	2,416	.525	83,820	11,902	22,122	4,955	361	2,808	11,327	7,923	857	19,314	1,358	416	93,514	36,223	8,124	254	660	507	1,866	.264	.331	.432	.764
24	Brewers	1,148	1,267	.475	2,415	.525	81,345	10,740	20,198	3,944	387	2,821	10,242	7,921	972	20,423	1,833	533	91,401	33,379	7,152	618	545	457	1,773	.248	.320	.410	.731
25	Guardians	1,139	1,270	.473	2,409	.527	81,418	10,624	20,391	4,218	353	2,490	10,100	7,785	889	18,144	1,674	490	91,198	32,785	7,061	422	684	417	1,736	.250	.320	.403	.723