The Texas Rangers had their lowest run differential in a game against the Oakland Athletics on September 30, 2000, with a differential of -21 runs.

Interpreted as:

texas rangers lowest run diff in a regular-season game

	TEAM	DIFF	DATE	TM		OPP	RESULT	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rangers	-21	9/30/2000	TEX	@	OAK	L 2-23	36	2	9	0	0	0	2	2	0	10	0	0	38	9	0	0	0	0	0	.250	.289	.250	.539
2	Rangers	-18	8/23/1999	TEX	vs	NYY	L 3-21	35	3	10	2	0	1	3	2	0	3	0	0	37	15	3	0	0	0	2	.286	.324	.429	.753
3	Rangers	-17	7/3/2012	TEX	@	CWS	L 2-19	34	2	9	2	0	0	2	1	0	5	0	0	35	11	2	0	0	0	2	.265	.286	.324	.609
4	Rangers	-17	5/20/1994	TEX	@	SEA	L 2-19	31	2	6	2	0	1	2	4	1	6	1	0	36	11	3	0	0	0	0	.194	.306	.355	.660
5	Senators	-17	8/23/1963	WSH	vs	LAA	L 0-17	25	0	3	0	0	0	0	3	2	6	0	0	30	3	0	0	0	0	5	.120	.267	.120	.387
6	Rangers	-16	7/28/2015	TEX	vs	NYY	L 5-21	30	5	3	1	0	0	5	6	0	5	0	0	36	4	1	0	0	0	0	.100	.250	.133	.383
7	Rangers	-16	8/5/1997	TEX	vs	BOS	L 1-17	30	1	5	0	0	1	1	4	0	9	0	0	34	8	1	0	0	0	2	.167	.265	.267	.531
8	Rangers	-16	6/29/1995	TEX	vs	CAL	L 4-20	33	4	7	2	0	1	4	5	1	8	0	0	39	12	3	0	0	0	1	.212	.333	.364	.697
9	Rangers	-16	5/20/1989	TEX	vs	MIN	L 3-19	36	3	9	1	0	3	3	2	0	2	0	1	38	19	4	0	0	0	0	.250	.289	.528	.817
10	Rangers	-15	8/12/2019	TEX	@	TOR	L 4-19	35	4	8	1	0	3	4	1	1	6	0	0	37	18	4	0	0	0	0	.229	.270	.514	.785
11	Rangers	-15	7/17/2019	TEX	vs	ARI	L 4-19	34	4	7	1	0	3	4	1	0	14	0	0	35	17	4	0	0	0	0	.206	.229	.500	.729
12	Rangers	-15	10/4/2001	TEX	@	SEA	L 1-16	33	1	4	1	0	1	1	2	0	7	0	0	35	8	2	0	0	0	0	.121	.171	.242	.414
13	Rangers	-15	8/9/1999	TEX	vs	TOR	L 4-19	33	4	7	0	1	2	4	2	1	5	0	1	37	15	3	0	1	0	0	.212	.270	.455	.725
14	Rangers	-15	9/14/1978	TEX	vs	CAL	L 1-16	30	1	5	2	0	1	1	4	1	2	1	1	35	10	3	0	0	0	0	.167	.286	.333	.619
15	Rangers	-15	7/7/1973	TEX	@	MIL	L 2-17	36	2	6	2	0	0	2	3	0	6	1	0	39	8	2	0	0	0	0	.167	.231	.222	.453
16	Rangers	-15	5/10/1973	TEX	vs	OAK	L 2-17	29	2	4	2	0	0	1	2	0	2	0	0	31	6	2	0	0	0	2	.138	.194	.207	.400
17	Rangers	-14	9/13/2021	TEX	vs	HOU	L 1-15	34	1	9	0	0	0	1	1	1	10	0	0	36	9	0	0	0	0	2	.265	.306	.265	.570
18	Rangers	-14	7/19/2021	TEX	@	DET	L 0-14	31	0	4	1	0	0	0	0	1	10	0	0	32	5	1	0	0	0	0	.129	.156	.161	.318
19	Rangers	-14	4/20/2014	TEX	vs	CWS	L 2-16	24	2	2	0	0	0	1	6	2	5	2	1	33	2	0	0	1	1	2	.083	.303	.083	.386
20	Rangers	-14	5/29/1993	TEX	@	BOS	L 1-15	36	1	6	2	0	0	0	1	0	9	0	0	37	8	2	0	0	0	0	.167	.189	.222	.411
21	Rangers	-14	9/29/1991	TEX	@	OAK	L 5-19	37	5	9	1	0	2	4	4	1	6	0	0	42	16	3	0	0	0	0	.243	.333	.432	.766
22	Rangers	-14	9/4/1973	TEX	@	CWS	L 0-14	32	0	5	0	0	0	0	0	0	5	1	0	32	5	0	0	0	0	0	.156	.156	.156	.313
23	Rangers	-14	7/3/1973	TEX	vs	CWS	L 1-15	31	1	4	0	0	0	0	4	0	5	0	0	35	4	0	0	0	0	1	.129	.229	.129	.358
24	Rangers	-14	4/18/1972	TEX	@	CWS	L 0-14	28	0	3	1	0	0	0	1	0	7	0	0	29	4	1	0	0	0	2	.107	.138	.143	.281
25	Senators	-14	9/7/1968	WSH	@	NYY	L 2-16	39	2	13	3	0	0	2	1	0	5	0	0	40	16	3	0	0	1	1	.333	.350	.410	.760