The New York Yankees have the highest run differential by a team, with a differential of 13,157 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	13,157	19,069	.570	10,813	8,168	649,918	92,672	172,541	28,653	5,497	17,329	86,110	68,624	4,930	94,907	11,656	2,802	736,357	264,175	51,479	9,595	3,290	2,838	10,688	.265	.339	.406	.745
2	Giants	7,473	21,779	.535	11,572	10,044	743,279	100,693	195,493	31,359	7,038	15,593	90,165	68,329	5,678	99,644	16,517	3,146	831,968	287,707	53,990	11,667	3,015	4,018	10,191	.263	.329	.387	.716
3	Dodgers	6,247	21,695	.532	11,466	10,090	739,227	97,958	193,142	31,069	7,006	14,142	88,176	68,938	5,153	100,420	17,347	3,552	829,231	280,649	52,217	12,774	3,063	3,737	9,951	.261	.327	.380	.707
4	Cubs	3,616	22,311	.513	11,362	10,788	763,529	102,750	199,971	33,771	7,360	15,263	88,335	68,601	5,285	105,113	15,804	3,072	853,353	294,251	56,394	13,027	2,911	3,522	9,967	.262	.326	.385	.711
5	Red Sox	3,589	19,359	.518	9,982	9,294	662,577	90,407	176,795	33,136	5,600	14,614	83,841	66,841	4,808	95,647	9,639	2,552	748,163	264,973	53,350	10,597	3,340	2,999	11,552	.267	.337	.400	.737
6	Guardians	2,246	19,367	.513	9,882	9,394	660,087	87,556	174,737	31,162	5,499	13,924	80,920	62,647	4,838	94,671	11,914	3,390	742,394	258,669	50,585	11,464	3,358	2,546	10,530	.265	.331	.392	.723
7	Browns	2,020	1,233	.644	781	432	43,777	7,933	11,555	1,658	602	304	4,657	3,473	353	436	2,307		47,743	15,329	2,564					.264	.325	.350	.675
8	Cardinals	1,972	20,662	.513	10,537	9,994	706,761	92,453	187,820	31,844	7,052	12,867	84,513	64,211	5,205	98,224	15,018	3,616	791,295	272,369	51,763	11,974	3,144	3,776	10,141	.266	.330	.385	.715
9	Braves	1,534	22,270	.504	11,139	10,977	762,481	99,533	198,029	32,116	6,301	15,061	86,579	67,518	5,069	100,196	14,100	3,067	850,634	287,930	53,478	12,685	2,881	3,655	10,387	.260	.323	.378	.701
10	Orioles	1,512	1,294	.579	730	530	45,361	8,530	13,521	1,814	865	218	6,940	4,345	992	2,952	2,993		51,317	17,719	2,897	619				.298	.372	.391	.763
11	Grays	909	725	.612	438	278	26,572	4,037	6,764	1,084	341	98	292	1,192					27,764	8,824	1,523					.255		.332
12	Reds	768	21,896	.504	10,962	10,795	746,067	98,254	194,387	32,403	7,561	14,330	87,395	66,738	5,508	102,356	18,168	3,410	834,183	284,902	54,294	12,662	3,040	3,647	9,722	.261	.325	.382	.707
13	Astros	742	10,034	.502	5,039	4,990	340,515	42,796	86,814	15,916	2,173	8,435	40,277	32,372	2,907	62,973	7,150	3,136	382,541	132,381	26,524	4,030	2,717	3,145	7,416	.255	.323	.389	.711
14	Reds	578	269	.659	174	90	9,515	2,020	2,647	386	176	106	1,548	1,303	109	499	859		10,927	3,703	668					.278	.371	.389	.761
15	Blue Jays	360	7,607	.498	3,788	3,816	260,613	35,148	67,762	13,540	1,492	8,263	33,338	24,176	2,427	49,023	4,577	1,963	290,847	109,075	23,295	1,504	2,127	1,403	5,934	.260	.326	.419	.745
16	Athletics	356	1,219	.529	633	564	43,556	7,481	11,208	1,782	741	284	4,168	3,158	351	548	1,900		47,191	15,324	2,807					.257	.315	.352	.666
17	Tigers	340	19,393	.503	9,713	9,587	661,319	89,058	174,712	29,607	6,296	14,585	82,010	65,576	4,452	96,811	11,292	2,938	745,466	260,666	50,488	11,009	3,110	2,448	10,720	.264	.333	.394	.727
18	Outlaw Reds	237	105	.657	69	36	3,786	703	1,027	118	63	26		147		482			3,933	1,349	207					.271		.356
19	Whales	207	312	.565	173	133	10,231	1,262	2,634	412	127	102	1,102	964	71	1,200	332		11,614	3,606	641	348				.257	.326	.352	.678
20	Dark Blues	198	129	.619	78	48	5,022	770	1,348	159	53	6		69					5,091	1,631	218					.268		.325
21	Peppers	163	312	.551	168	137	10,273	1,347	2,757	440	170	50	1,116	908	72	1,160	457		11,678	3,687	660	425				.268	.332	.359	.691
22	Giants	143	132	.565	74	57	4,913	1,018	1,393	204	97	66	793	486	31	364	231		5,430	1,989	367					.284	.352	.405	.757
23	Brown Stockings	123	124	.589	73	51	4,656	670	1,173	124	63	3		116					4,772	1,432	190					.252		.308
24	Pirates	116	138	.547	75	62	4,968	886	1,311	200	95	31	705	492	43	410	276		5,503	1,794	326					.264	.335	.361	.697
25	Maroons	90	351	.504	173	170	12,293	1,824	3,081	563	108	70	684	630			156		12,923	4,070	741					.251		.331