The Philadelphia Phillies have the lowest run differential by a team with 82+ games played, with a differential of -5,705 runs.

Interpreted as:

worst run differential through 82 or more games

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Phillies	-5,705	21,723	.474	10,252	11,356	743,284	96,461	193,541	33,458	6,682	14,222	86,680	67,831	5,426	105,552	14,982	2,920	831,479	283,029	54,362	11,919	3,019	3,742	9,876	.260	.326	.381	.706
2	Orioles	-5,434	19,388	.475	9,152	10,126	658,558	83,713	169,928	29,370	4,914	14,466	77,399	63,364	4,486	98,586	10,575	2,788	740,050	252,524	48,750	10,532	3,110	2,579	10,866	.258	.326	.383	.709
3	Twins	-3,235	19,397	.482	9,296	9,992	661,698	85,292	173,520	29,797	6,335	12,052	78,530	62,444	5,179	94,700	12,024	3,084	742,681	252,143	48,184	10,190	3,170	2,664	10,990	.262	.329	.381	.710
4	Athletics	-3,143	19,352	.486	9,360	9,905	655,957	85,409	168,837	29,251	5,334	14,178	78,709	64,615	4,742	99,288	12,126	3,210	739,104	251,290	48,763	10,683	3,107	2,272	10,644	.257	.327	.383	.710
5	Padres	-2,850	8,920	.467	4,167	4,751	301,540	36,158	75,185	13,307	1,765	7,281	34,001	28,699	2,134	59,672	6,023	2,608	338,350	113,865	22,353	3,718	2,259	2,689	6,520	.249	.317	.378	.694
6	Marlins	-2,248	5,085	.459	2,332	2,753	172,853	21,387	44,037	8,374	986	4,628	20,279	15,623	1,839	38,478	3,268	1,302	193,322	68,267	13,988	1,722	1,285	1,203	3,819	.255	.321	.395	.716
7	Royals	-2,174	8,908	.477	4,245	4,661	304,687	38,926	80,005	14,952	2,295	7,025	36,740	26,055	2,467	52,299	7,108	2,905	338,261	120,622	24,272	2,376	2,676	1,872	6,795	.263	.323	.396	.719
8	Rangers	-2,066	10,201	.476	4,854	5,341	348,213	45,880	89,787	16,009	1,894	10,223	43,352	32,971	2,711	65,403	5,965	2,854	389,697	140,253	28,126	2,964	2,838	2,254	7,806	.258	.324	.403	.727
9	Rockies	-1,944	5,095	.459	2,338	2,757	174,976	25,172	47,244	9,330	1,320	5,759	23,939	16,053	1,594	37,984	3,068	1,375	195,991	76,491	16,409	2,006	1,362	1,209	3,886	.270	.335	.437	.772
10	Colonels	-1,890	2,355	.429	993	1,320	82,256	12,464	21,505	2,816	1,292	436	8,508	6,080	757	3,638	3,474		89,787	28,213	4,544	609				.261	.319	.343	.662
11	Senators	-1,865	1,265	.366	454	788	43,645	6,912	11,886	1,615	787	357	5,764	4,269	575	3,492	1,975		48,963	16,146	2,759	474				.272	.345	.370	.715
12	Mariners	-1,652	7,625	.477	3,637	3,986	260,113	33,844	66,830	12,459	1,260	7,760	32,154	24,655	2,363	49,973	5,052	2,175	291,161	105,089	21,479	1,950	2,080	1,668	5,695	.257	.324	.404	.729
13	Nationals	-1,499	8,913	.482	4,296	4,613	301,434	37,330	76,468	14,759	1,792	7,627	35,087	28,324	2,641	57,356	6,563	2,787	338,571	117,692	24,178	3,882	2,290	2,883	6,522	.254	.321	.390	.711
14	Nationals	-1,080	514	.326	163	337	17,337	2,160	3,944	533	220	125	1,647	1,246	127		1,040		18,710	5,292	878					.227	.284	.305	.589
15	Orioles	-802	944	.437	403	519	32,654	4,964	7,699	1,083	504	136	2,635	2,289	208		1,451		35,293	10,198	1,723					.236	.293	.312	.605
16	Brewers	-794	8,917	.488	4,348	4,565	302,666	39,632	77,486	14,442	1,759	8,734	37,549	29,133	2,721	59,147	6,014	2,740	340,109	121,648	24,935	3,167	2,422	2,161	6,622	.256	.325	.402	.726
17	Mets	-761	10,047	.484	4,861	5,178	339,912	41,459	84,926	15,172	1,819	8,619	39,044	32,508	2,880	65,175	5,912	2,739	381,915	129,593	25,610	3,989	2,626	3,145	7,482	.250	.318	.381	.700
18	Angels	-718	10,213	.495	5,057	5,153	346,500	44,187	88,628	15,318	1,813	9,254	41,580	32,387	2,840	63,001	6,060	3,107	388,045	135,334	26,385	3,541	2,777	2,487	7,891	.256	.322	.391	.713
19	Spiders	-672	1,802	.469	827	938	63,232	10,057	17,006	2,308	961	292	8,238	5,871	580	3,144	2,800		70,233	22,112	3,561	550				.269	.337	.350	.686
20	Reds	-638	348	.365	125	217	12,768	1,643	3,191	408	157	30		318					13,086	4,003	595					.250		.314
21	Hoosiers	-540	398	.370	146	249	13,870	2,050	3,536	570	138	129	1,577	913	131		936		14,914	4,769	837					.255	.307	.344	.651
22	Cowboys	-496	271	.364	98	171	9,535	1,431	2,256	304	137	37	1,052	718	123		729		10,376	2,945	478					.237	.298	.309	.607
23	Rays	-409	4,345	.491	2,132	2,213	147,719	19,332	37,498	7,472	853	4,530	18,390	14,052	1,688	33,648	3,250	1,236	165,364	60,266	12,855	744	1,161	688	3,041	.254	.323	.408	.731
24	Bisons	-406	134	.273	36	96	4,795	793	1,249	180	64	20	630	541	96	367	160		5,432	1,617	264					.260	.347	.337	.684
25	Trojans	-388	330	.412	134	191	11,951	1,542	2,929	456	151	26		414					12,365	3,765	633					.245		.315