The Philadelphia Phillies have the lowest run differential by a team with 82+ games played, with a differential of -5,730 runs.

Interpreted as:

worst run differential through 82 or more games

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Phillies	-5,730	21,682	.474	10,226	11,341	741,887	96,272	193,182	33,393	6,677	14,176	86,497	67,701	5,409	105,240	14,948	2,911	829,922	282,457	54,246	11,914	3,011	3,739	9,856	.260	.326	.381	.706
2	Orioles	-5,413	19,347	.475	9,133	10,104	657,165	83,545	169,579	29,304	4,909	14,421	77,242	63,248	4,471	98,215	10,540	2,778	738,512	251,964	48,634	10,530	3,098	2,574	10,832	.258	.326	.383	.709
3	Twins	-3,245	19,358	.482	9,274	9,975	660,373	85,111	173,189	29,739	6,331	11,999	78,355	62,326	5,153	94,364	12,008	3,078	741,204	251,587	48,069	10,189	3,163	2,661	10,963	.262	.329	.381	.710
4	Athletics	-3,038	19,311	.486	9,349	9,875	654,553	85,238	168,488	29,175	5,332	14,127	78,542	64,476	4,729	98,921	12,098	3,205	737,543	250,708	48,634	10,682	3,103	2,269	10,607	.257	.327	.383	.710
5	Padres	-2,832	8,880	.467	4,150	4,728	300,179	35,983	74,856	13,247	1,757	7,247	33,839	28,579	2,122	59,378	6,000	2,603	336,832	113,358	22,251	3,709	2,243	2,685	6,494	.249	.317	.378	.695
6	Marlins	-2,213	5,046	.459	2,316	2,730	171,531	21,243	43,703	8,315	979	4,595	20,139	15,507	1,831	38,189	3,240	1,288	191,858	67,761	13,889	1,716	1,273	1,202	3,790	.255	.321	.395	.716
7	Royals	-2,153	8,869	.477	4,228	4,639	303,357	38,796	79,663	14,893	2,284	6,997	36,614	25,974	2,455	52,042	7,081	2,893	336,816	120,115	24,174	2,364	2,666	1,865	6,772	.263	.323	.396	.719
8	Rangers	-2,100	10,161	.476	4,835	5,320	346,880	45,723	89,483	15,951	1,891	10,178	43,202	32,849	2,693	65,068	5,931	2,845	388,212	139,750	28,020	2,963	2,827	2,250	7,791	.258	.325	.403	.727
9	Colonels	-1,890	2,355	.429	993	1,320	82,256	12,464	21,505	2,816	1,292	436	8,508	6,080	757	3,638	3,474		89,787	28,213	4,544	609				.261	.319	.343	.662
10	Senators	-1,865	1,265	.366	454	788	43,645	6,912	11,886	1,615	787	357	5,764	4,269	575	3,492	1,975		48,963	16,146	2,759	474				.272	.345	.370	.715
11	Rockies	-1,837	5,054	.460	2,327	2,727	173,588	25,017	46,910	9,261	1,304	5,713	23,787	15,946	1,578	37,596	3,049	1,363	194,467	75,918	16,278	2,002	1,353	1,207	3,852	.270	.335	.437	.772
12	Mariners	-1,631	7,585	.477	3,619	3,964	258,740	33,692	66,498	12,401	1,258	7,714	32,005	24,536	2,346	49,601	5,015	2,167	289,640	104,557	21,373	1,945	2,073	1,664	5,672	.257	.325	.404	.729
13	Nationals	-1,457	8,873	.483	4,281	4,588	300,108	37,171	76,153	14,686	1,788	7,591	34,935	28,219	2,618	57,083	6,538	2,771	337,105	117,188	24,065	3,877	2,283	2,880	6,490	.254	.321	.390	.712
14	Nationals	-1,080	514	.326	163	337	17,337	2,160	3,944	533	220	125	1,647	1,246	127		1,040		18,710	5,292	878					.227	.284	.305	.589
15	Brewers	-804	8,878	.487	4,326	4,548	301,370	39,475	77,180	14,385	1,755	8,694	37,397	29,002	2,706	58,811	5,966	2,728	338,652	121,157	24,834	3,160	2,414	2,158	6,606	.256	.325	.402	.727
16	Orioles	-802	944	.437	403	519	32,654	4,964	7,699	1,083	504	136	2,635	2,289	208		1,451		35,293	10,198	1,723					.236	.293	.312	.605
17	Mets	-772	10,008	.484	4,839	5,161	338,616	41,299	84,618	15,117	1,815	8,566	38,886	32,371	2,853	64,854	5,873	2,734	380,442	129,063	25,498	3,987	2,615	3,137	7,449	.250	.318	.381	.699
18	Angels	-722	10,172	.495	5,034	5,135	345,124	44,001	88,307	15,265	1,808	9,193	41,403	32,273	2,817	62,600	6,042	3,097	386,517	134,767	26,266	3,536	2,767	2,482	7,870	.256	.322	.390	.713
19	Spiders	-672	1,802	.469	827	938	63,232	10,057	17,006	2,308	961	292	8,238	5,871	580	3,144	2,800		70,233	22,112	3,561	550				.269	.337	.350	.686
20	Reds	-638	348	.365	125	217	12,768	1,643	3,191	408	157	30		318					13,086	4,003	595					.250		.314
21	Hoosiers	-540	398	.370	146	249	13,870	2,050	3,536	570	138	129	1,577	913	131		936		14,914	4,769	837					.255	.307	.344	.651
22	Cowboys	-496	271	.364	98	171	9,535	1,431	2,256	304	137	37	1,052	718	123		729		10,376	2,945	478					.237	.298	.309	.607
23	Rays	-471	4,304	.490	2,107	2,197	146,342	19,117	37,139	7,406	850	4,480	18,187	13,928	1,671	33,299	3,190	1,219	163,829	59,685	12,736	737	1,151	685	3,020	.254	.323	.408	.731
24	Bisons	-406	134	.273	36	96	4,795	793	1,249	180	64	20	630	541	96	367	160		5,432	1,617	264					.260	.347	.337	.684
25	Trojans	-388	330	.412	134	191	11,951	1,542	2,929	456	151	26		414					12,365	3,765	633					.245		.315