Nolan Ryan played the most seasons with 100+ strikeouts, with 24 seasons.

	NAME	SEAS	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Nolan Ryan N. Ryan	24	5,570	767	313	283	.525	749	3.16	220	61	2	5227.1	3,804	1,835	2,088	312	2,699	156	9	74	21,892	272	9.59	4.65	2.06	0.54	25.4	12.3	1.24	.265	3.59	89	2.95	83	6.55	365.1
2	Roger Clemens R. Clemens	22	4,530	676	341	173	.663	675	3.10	115	45	0	4719.1	4,003	1,625	1,795	349	1,512	151	0	63	19,413	135	8.64	2.88	3.00	0.67	23.3	7.8	1.17	.284	3.42	70	3.06	70	7.63	666.5
3	Greg Maddux G. Maddux	21	3,253	705	345	210	.622	702	3.10	108	35	0	4783.1	4,478	1,646	1,856	329	958	130	2	170	19,473	66	6.12	1.80	3.40	0.62	16.7	4.9	1.14	.280	3.49	75	3.22	77	8.43	516.6
4	Don Sutton D. Sutton	21	3,431	723	310	239	.565	706	3.19	177	58	5	5003.1	4,402	1,776	1,959	427	1,272	74	12	96	20,456	103	6.17	2.29	2.70	0.77	16.8	6.2	1.13	.261	3.52	91	3.15	89	7.92	199.6
5	Bert Blyleven B. Blyleven	19	3,543	640	269	229	.540	634	3.21	239	60	0	4682.2	4,303	1,671	1,854	396	1,257	143	3	69	19,256	105	6.81	2.42	2.82	0.76	18.4	6.5	1.19	.281	3.56	83	3.13	81	8.27	369.4
6	Steve Carlton S. Carlton	19	3,946	665	319	218	.594	660	3.11	249	54	1	4887.0	4,320	1,690	1,928	374	1,663	48	2	139	20,208	166	7.27	3.06	2.37	0.69	19.5	8.2	1.22	.278	3.55	85	3.04	84	7.96	299
7	CC Sabathia	18	3,045	553	248	157	.612	552	3.72	38	12	0	3531.1	3,346	1,458	1,592	372	1,089	119	0	44	14,780	72	7.76	2.78	2.80	0.95	20.6	7.4	1.26	.293	4.06	86	3.76	87	8.53	227.8
8	Randy Johnson R. Johnson	18	4,607	568	283	157	.643	564	3.25	99	37	1	3895.1	3,126	1,405	1,587	374	1,421	182	3	32	16,057	97	10.64	3.28	3.24	0.86	28.7	8.8	1.17	.291	3.67	74	3.13	72	7.22	543
9	Phil Niekro P. Niekro	18	3,061	703	287	237	.548	635	3.22	235	42	21	4775.2	4,384	1,711	1,982	420	1,536	106	49	74	19,897	192	5.77	2.89	1.99	0.79	15.4	7.7	1.24	.268	3.74	84	3.50	92	8.26	153.1
10	Tom Seaver T. Seaver	18	3,491	612	292	190	.606	603	2.81	225	60	1	4505.1	3,715	1,406	1,548	356	1,280	70	6	104	18,197	118	6.97	2.56	2.73	0.71	19.2	7.0	1.11	.258	3.09	77	2.97	83	7.42	298.6
11	Gaylord Perry G. Perry	18	3,320	680	295	235	.557	626	2.99	296	52	8	4894.0	4,404	1,625	1,880	353	1,263	98	26	150	19,963	145	6.11	2.32	2.63	0.65	16.6	6.3	1.16	.271	3.46	83	2.98	83	8.10	317.3
12	Walter Johnson W. Johnson	18	3,312	749	399	254	.611	624	2.09	501	103	31	5552.2	4,565	1,290	1,729	84	1,290	191	117		21,930	144	5.37	2.09	2.57	0.14	15.1	5.9	1.05	.263	2.80	66	2.39	75	7.40	451.3
13	Cy Young C. Young	18	2,563	804	467	271	.633	723	2.53	672	71	17	6583.0	6,270	1,850	2,754	119	1,083	136	76		26,385	122	3.50	1.48	2.37	0.16	9.7	4.1	1.12	.274	3.77	71	2.80	78	8.57	578
14	Warren Spahn W. Spahn	17	2,341	648	342	211	.618	592	2.96	361	62	23	4731.0	4,284	1,557	1,741	379	1,279	36	46	54	19,349	69	4.45	2.43	1.83	0.72	12.1	6.6	1.18	.255	3.31	80	3.39	92	8.15	154.9
15	Justin Verlander J. Verlander	16	3,328	506	256	139	.648	506	3.23	26	9	0	3308.0	2,775	1,186	1,287	337	919	108	0	27	13,474	94	9.05	2.50	3.62	0.92	24.7	6.8	1.12	.278	3.50	76	3.37	80	7.55	317.4
16	Zack Greinke Z. Greinke	16	2,737	515	215	129	.625	476	3.40	17	5	1	3036.2	2,818	1,146	1,230	321	700	71	7	23	12,398	89	8.11	2.07	3.91	0.95	22.1	5.6	1.16	.291	3.65	81	3.44	83	8.35	232.6
17	Tom Glavine T. Glavine	16	2,205	531	258	148	.635	531	3.30	48	20	0	3534.2	3,379	1,298	1,431	264	1,197	46	0	118	14,829	56	5.61	3.05	1.84	0.67	14.9	8.1	1.29	.280	3.64	79	3.80	90	8.60	163.4
18	Frank Tanana F. Tanana	16	2,449	530	207	190	.521	511	3.58	124	30	1	3549.1	3,421	1,411	1,581	382	1,034	109	10	93	14,905	98	6.21	2.62	2.37	0.97	16.4	6.9	1.26	.278	4.01	93	3.71	95	8.67	81.5
19	Fergie Jenkins F. Jenkins	16	3,023	605	271	208	.566	549	3.27	265	48	6	4215.0	3,837	1,533	1,706	449	909	78	28	107	17,182	58	6.45	1.94	3.33	0.96	17.6	5.3	1.13	.266	3.64	85	3.22	86	8.19	231.8
20	Clayton Kershaw C. Kershaw	15	2,882	415	204	90	.694	412	2.49	25	15	0	2654.1	2,014	733	798	217	661	41	1	27	10,462	101	9.77	2.24	4.36	0.74	27.5	6.3	1.01	.270	2.71	64	2.80	69	6.83	357.4
21	Andy Pettitte A. Pettitte	15	2,203	482	232	140	.624	472	3.90	23	3	0	3023.0	3,168	1,309	1,451	266	947	51	3	38	12,855	62	6.56	2.82	2.33	0.79	17.1	7.4	1.36	.309	4.32	87	3.78	84	9.43	244.9
22	Mike Mussina M. Mussina	15	2,571	473	239	133	.642	473	3.67	52	23	0	3146.2	3,032	1,283	1,375	336	687	54	0	26	12,876	67	7.35	1.96	3.74	0.96	20.0	5.3	1.18	.292	3.93	81	3.52	78	8.67	347.1
23	Jack Morris J. Morris	15	2,305	489	236	173	.577	489	3.94	159	27	0	3474.1	3,269	1,520	1,669	363	1,240	53	0	83	14,664	198	5.97	3.21	1.86	0.94	15.7	8.5	1.30	.272	4.32	96	3.94	94	8.47	92.9
24	Max Scherzer M. Scherzer	14	3,209	429	208	100	.675	429	3.13	11	5	0	2711.1	2,188	944	1,009	313	702	105	0	18	10,920	68	10.65	2.33	4.57	1.04	29.4	6.4	1.07	.284	3.35	75	3.15	76	7.26	295.5
25	Cole Hamels C. Hamels	14	2,558	422	163	121	.574	421	3.42	17	7	0	2694.2	2,421	1,024	1,100	310	766	100	0	43	11,101	57	8.54	2.56	3.34	1.04	23.0	6.9	1.18	.287	3.67	82	3.68	88	8.09	150.7