InterContinental Hotels Group PLC ADR (IHG) had the highest return between 2000 and 2008 by a US stock, returning 5,519,600%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2000-2008	5,519,600%
QVC (QVCGA)	2000-2008	1,617,809.26%
India Globalization Capital (IGC)	2000-2008	1,616,566.67%
National Grid PLC ADR (NGG)	2000-2008	1,018,952.94%
Natwest (NWG)	2000-2008	953,400%
Hirequest (HQI)	2000-2008	935,500%
Houston American Energy (HUSA)	2000-2008	875,802.7%
Northern Oil & Gas (NOG)	2000-2008	852,476.92%
Know Labs (KNW)	2000-2008	534,224.43%
Gladstone Capital (GLAD)	2000-2008	166,055%
Ring Energy (REI)	2000-2008	146,566.67%
OPTIMIZERx (OPRX)	2000-2008	124,100%
Ocean Power Technologies (OPTT)	2000-2008	74,233.33%
Perspective Therapeutics (CATX)	2000-2008	66,566.67%
Future Fintech (FTFT)	2000-2008	12,400%
NanoViricides (NNVC)	2000-2008	11,240%
First Majestic Silver (AG)	2000-2008	7,838.67%
Gyre Therapeutics (GYRE)	2000-2008	7,448.45%
TherapeuticsMD (TXMD)	2000-2008	7,439.95%
Monster Beverage (MNST)	2000-2008	6,165.02%
Cryoport (CYRX)	2000-2008	5,997.3%
Gulf Resources (GURE)	2000-2008	5,900%
Broadwind Energy (BWEN)	2000-2008	5,300.22%
Clean Harbors (CLH)	2000-2008	5,105.12%
Companhia Siderurgica Nacional ADR (SID)	2000-2008	4,336.27%