Celestica (CLS) has had the highest return between 2021 and 2025 by a large-cap US stock, returning 3,852.1%.

ASSET	YEARS	% RETURN
Celestica (CLS)	2021-2025	3,852.15%
Sterling Construction (STRL)	2021-2025	1,922.7%
Comfort Systems USA (FIX)	2021-2025	1,753.12%
NVIDIA (NVDA)	2021-2025	1,339.74%
Credo Technology (CRDO)	2021-2025	1,252.15%
Super Micro Computer (SMCI)	2021-2025	1,150.31%
Carpenter Technology (CRS)	2021-2025	1,099.35%
Oklo (OKLO)	2021-2025	1,026.5%
Vistra Energy (VST)	2021-2025	979.79%
Permian Resources (PR)	2021-2025	892%
Fortress Transp & Infra Inv (FTAI)	2021-2025	875.2%
Constellation Energy (CEG)	2021-2025	874.25%
Vertiv (VRT)	2021-2025	862.21%
Embraer SA ADR (ERJ)	2021-2025	834.27%
Applovin (APP)	2021-2025	785.61%
Broadcom (AVGO)	2021-2025	782.38%
Flex (FLEX)	2021-2025	656.36%
YPF Sociedad Anonima (YPF)	2021-2025	650.72%
Palantir Technologies Inc Class A Common Stock (PLTR)	2021-2025	644.17%
Arista Networks (ANET)	2021-2025	640.95%
Howmet Aerospace (HWM)	2021-2025	635.3%
EMCOR (EME)	2021-2025	617.26%
Targa Resources (TRGP)	2021-2025	609.55%
Cameco (CCJ)	2021-2025	592.56%
Symbotic (SYM)	2021-2025	571.8%

Large-cap stocks are treated as having a market cap of $10B+.