InterContinental Hotels Group PLC ADR (IHG) had the highest return between 2003 and 2004 by a large-cap US stock, returning 8,020,800%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2003-2004	8,020,800%
Axon Enterprise (AXON)	2003-2004	9,277.78%
Cheniere Energy (LNG)	2003-2004	4,799.94%
ArcelorMittal SA ADR (MT)	2003-2004	1,656.81%
Deckers Outdoor (DECK)	2003-2004	1,319.58%
Williams Companies (WMB)	2003-2004	996.48%
Chunghwa Telecom (CHT)	2003-2004	845.27%
Monster Beverage (MNST)	2003-2004	764.01%
Akamai Technologies (AKAM)	2003-2004	623.89%
Bancolombia SA ADR (CIB)	2003-2004	568.75%
CME (CME)	2003-2004	433.5%
Autodesk (ADSK)	2003-2004	433.09%
WESCO International (WCC)	2003-2004	430.24%
Wynn Resorts (WYNN)	2003-2004	414.38%
Insmed (INSM)	2003-2004	399.77%
Carpenter Technology (CRS)	2003-2004	380.36%
Vale SA ADR (VALE)	2003-2004	358.81%
YPF Sociedad Anonima (YPF)	2003-2004	357.15%
F5 Networks (FFIV)	2003-2004	353.21%
NetEase (NTES)	2003-2004	351.9%
Apple (AAPL)	2003-2004	348.33%
Cameco (CCJ)	2003-2004	344.63%
Telefonaktiebolaget LM Ericsson B ADR (ERIC)	2003-2004	331.97%
Teck Resources Ltd Class B (TECK)	2003-2004	328.44%
Ambev SA ADR (ABEV)	2003-2004	319.4%

Large-cap stocks are treated as having a market cap of $10B+.