InterContinental Hotels Group PLC ADR (IHG) had the highest return between 2002 and 2003 by a large-cap US stock, returning 5,929,900%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2002-2003	5,929,900%
NetEase (NTES)	2002-2003	4,825.76%
Cheniere Energy (LNG)	2002-2003	1,131.46%
Coeur Mining (CDE)	2002-2003	588.1%
Axon Enterprise (AXON)	2002-2003	502.6%
Chunghwa Telecom (CHT)	2002-2003	501.4%
ArcelorMittal SA ADR (MT)	2002-2003	392.78%
Amazon (AMZN)	2002-2003	381.16%
Deckers Outdoor (DECK)	2002-2003	363.72%
Tractor Supply (TSCO)	2002-2003	355.29%
Southern Copper (SCCO)	2002-2003	317.83%
Royal Gold (RGLD)	2002-2003	313.69%
Dick’s Sporting Goods (DKS)	2002-2003	297.54%
Tapestry (TPR)	2002-2003	292%
ICICI Bank (IBN)	2002-2003	291.8%
Old Dominion Freight Line (ODFL)	2002-2003	283.54%
Rambus (RMBS)	2002-2003	280.42%
Kinross Gold (KGC)	2002-2003	275.11%
Grupo Cibest (CIB)	2002-2003	269.49%
Crown (CCK)	2002-2003	255.28%
Pan American Silver (PAAS)	2002-2003	238.86%
Netflix (NFLX)	2002-2003	237.81%
Cognizant Technology Solutions Corp Class A (CTSH)	2002-2003	234.64%
Telkom Indonesia (Persero) Tbk PT ADR Rep 100 B (TLK)	2002-2003	227.11%
Freeport-McMoran Copper & Gold (FCX)	2002-2003	221.47%

Large-cap stocks are treated as having a market cap of $10B+.