Expedia (EXPE) had the highest return between 2000 and 2005 by a US stock in the S&P 500 (GSPC), returning 5,826.9%.

ASSET	YEARS	% RETURN
Expedia (EXPE)	2000-2005	5,826.94%
Monster Beverage (MNST)	2000-2005	3,581.39%
NVR (NVR)	2000-2005	1,370.16%
Tapestry (TPR)	2000-2005	1,233.6%
Tractor Supply (TSCO)	2000-2005	1,217.48%
DaVita HealthCare Partners (DVA)	2000-2005	1,025.33%
Deckers Outdoor (DECK)	2000-2005	952.4%
Valero Energy (VLO)	2000-2005	951.94%
DR Horton (DHI)	2000-2005	898.89%
CME (CME)	2000-2005	866.49%
Lennar (LEN)	2000-2005	852.51%
UnitedHealth (UNH)	2000-2005	838.2%
EOG Resources (EOG)	2000-2005	775.63%
Old Dominion Freight Line (ODFL)	2000-2005	746.34%
W R Berkley (WRB)	2000-2005	696.27%
Gilead Sciences (GILD)	2000-2005	636.23%
Pool (POOL)	2000-2005	619.62%
PulteGroup (PHM)	2000-2005	616.7%
Quest Diagnostics (DGX)	2000-2005	577.83%
Paramount Skydance Corporation Class B Common Stock (PSKY)	2000-2005	572.3%
Brown & Brown (BRO)	2000-2005	569.83%
Humana (HUM)	2000-2005	553.6%
Intuitive Surgical (ISRG)	2000-2005	551.53%
JB Hunt Transport Services (JBHT)	2000-2005	547.11%
BlackRock (BLK)	2000-2005	545.6%