GeoVax Labs (GOVX) had the best year in the 2010s by a US stock in 2010, returning 5,263,157,794.2%.

ASSET	YEAR	% RETURN
GeoVax Labs (GOVX)	2010	5,263,157,794.21%
GT Biopharma (GTBP)	2012	3,044,698,370%
LM Funding America (LMFA)	2015	8,979,697.98%
QXO (QXO)	2012	8,064,250%
Castellum (CTM)	2011	6,521,639.13%
KULR Technology (KULR)	2018	5,199,900%
Alarum Technologies (ALAR)	2018	4,829,168.29%
Sequans Communications (SQNS)	2011	3,349,297.59%
Akari Therapeutics (AKTX)	2014	2,704,125.35%
Avalon GloboCare (ALBT)	2018	2,578,025%
Processa Pharmaceuticals (PCSA)	2014	1,796,566.67%
Aurora Cannabis (ACB)	2014	1,403,950.67%
Anfield Energy (AEC)	2012	1,091,672.15%
AquaBounty Technologies (AQB)	2017	977,677.78%
Nutex Health (NUTX)	2013	749,900%
Iqstel (IQST)	2018	565,237.99%
Delcath Systems (DCTH)	2018	381,222.96%
TCTM Kids IT Education (VSA)	2014	348,985.31%
INVO Fertility (IVF)	2012	314,081.93%
MMTEC (MTC)	2019	306,383.3%
NextTrip (NTRP)	2010	199,900%
Immatics (IMTX)	2018	195,900%
Versus Systems Inc. (VS)	2012	163,639.24%
Fubotv (FUBO)	2019	121,886.3%
Prairie Operating Co Common Stock (PROP)	2013	108,208.47%