Ovintiv (OVV) had the highest return between 2001 and 2004 by a large-cap US stock, returning 47,957,700%.

ASSET	YEARS	% RETURN
Ovintiv (OVV)	2001-2004	47,957,700%
Axon Enterprise (AXON)	2001-2004	5,326.02%
Cheniere Energy (LNG)	2001-2004	2,576.47%
Tractor Supply (TSCO)	2001-2004	1,651.26%
NetEase (NTES)	2001-2004	1,593.68%
ArcelorMittal SA ADR (MT)	2001-2004	1,527.37%
Monster Beverage (MNST)	2001-2004	855.42%
Chunghwa Telecom (CHT)	2001-2004	845.27%
Deckers Outdoor (DECK)	2001-2004	839.74%
Clean Harbors (CLH)	2001-2004	747.18%
Bancolombia SA ADR (CIB)	2001-2004	695.83%
Tapestry (TPR)	2001-2004	688.12%
Old Dominion Freight Line (ODFL)	2001-2004	682.91%
Cognizant Technology Solutions Corp Class A (CTSH)	2001-2004	596.41%
eBay (EBAY)	2001-2004	590.69%
Royal Gold (RGLD)	2001-2004	540.92%
Cameco (CCJ)	2001-2004	529.39%
NVR (NVR)	2001-2004	522.49%
Genesis Healthcare (GEN)	2001-2004	503.89%
Telkom Indonesia (Persero) Tbk PT ADR Rep 100 B (TLK)	2001-2004	498.78%
CME (CME)	2001-2004	497.23%
Centene (CNC)	2001-2004	495.99%
Pan American Silver (PAAS)	2001-2004	487.76%
Dick’s Sporting Goods (DKS)	2001-2004	474.35%
CACI International (CACI)	2001-2004	473.73%

Large-cap stocks are treated as having a market cap of $10B+.