Ferguson (FERG) had the highest return between 2008 and 2010 by a US stock with a market cap of $10B+, returning 104,868.6%.

ASSET	YEARS	% RETURN
Ferguson (FERG)	2008-2010	104,868.56%
Netflix (NFLX)	2008-2010	561.52%
F5 Networks (FFIV)	2008-2010	364.53%
Edwards Lifesciences (EW)	2008-2010	253.63%
Booking (BKNG)	2008-2010	242.23%
Skyworks Solutions (SWKS)	2008-2010	238.02%
Alamos Gold (AGI)	2008-2010	232.24%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2008-2010	228.12%
Dollar Tree (DLTR)	2008-2010	224.54%
Pegasystems (PEGA)	2008-2010	216.74%
Tractor Supply (TSCO)	2008-2010	173.96%
Ross Stores (ROST)	2008-2010	157.18%
Waste Connections (WCN)	2008-2010	156.88%
Ford Motor (F)	2008-2010	149.48%
Banco De Chile (BCH)	2008-2010	144.82%
Baidu (BIDU)	2008-2010	144.69%
Westlake Chemical (WLK)	2008-2010	135.96%
XPO Logistics (XPO)	2008-2010	132.75%
AutoZone (AZO)	2008-2010	126.97%
Wheaton Precious Metals (WPM)	2008-2010	126.58%
Franco-Nevada (FNV)	2008-2010	123.92%
NetApp (NTAP)	2008-2010	118.88%
Ambev SA ADR (ABEV)	2008-2010	118.38%
Cognizant Technology Solutions Corp Class A (CTSH)	2008-2010	116.64%
Ecopetrol SA ADR (EC)	2008-2010	114.38%