InterContinental Hotels Group PLC ADR (IHG) had the highest return between 2002 and 2005 by a large-cap US stock, returning 9,214,600%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2002-2005	9,214,600%
Ovintiv (OVV)	2002-2005	10,981.03%
Cheniere Energy (LNG)	2002-2005	7,736.53%
NetEase (NTES)	2002-2005	7,390.03%
Expedia (EXPE)	2002-2005	5,826.94%
Monster Beverage (MNST)	2002-2005	3,614.71%
Grupo Cibest (CIB)	2002-2005	2,105.62%
ArcelorMittal SA ADR (MT)	2002-2005	1,379.56%
Sterling Construction (STRL)	2002-2005	884.21%
CME (CME)	2002-2005	866.49%
Paramount Skydance Corporation Class B Common Stock (PSKY)	2002-2005	840.94%
Chunghwa Telecom (CHT)	2002-2005	786.56%
Canadian Natural Resources (CNQ)	2002-2005	765.24%
Clean Harbors (CLH)	2002-2005	760%
Banco Bradesco SA ADR (BBD)	2002-2005	755.38%
WESCO International (WCC)	2002-2005	754.59%
Cameco (CCJ)	2002-2005	716.06%
Hologic (HOLX)	2002-2005	715.48%
Tenaris SA ADR (TS)	2002-2005	678.91%
Crown (CCK)	2002-2005	665.86%
Vale SA ADR (VALE)	2002-2005	644.09%
Cognizant Technology Solutions Corp Class A (CTSH)	2002-2005	637.21%
Southern Copper (SCCO)	2002-2005	608.53%
Alamos Gold (AGI)	2002-2005	607.69%
Royal Gold (RGLD)	2002-2005	598.5%

Large-cap stocks are treated as having a market cap of $10B+.