QXO (QXO) had the highest return between 2010 and 2016 by a large-cap US stock, returning 3,450,050%.

ASSET	YEARS	% RETURN
QXO (QXO)	2010-2016	3,450,050%
Domino's Pizza Inc Common Stock (DPZ)	2010-2016	2,016.97%
Cheniere Energy (LNG)	2010-2016	1,557.19%
Netflix (NFLX)	2010-2016	1,460.96%
Regeneron Pharmaceuticals (REGN)	2010-2016	1,414.39%
Neurocrine Biosciences (NBIX)	2010-2016	1,297.11%
Jazz Pharmaceuticals (JAZZ)	2010-2016	1,252.73%
Ulta Beauty (ULTA)	2010-2016	1,240.58%
Expedia (EXPE)	2010-2016	1,057.04%
Tesla (TSLA)	2010-2016	1,024.65%
Incyte (INCY)	2010-2016	987.53%
United Rentals (URI)	2010-2016	964.31%
Broadcom (AVGO)	2010-2016	964.25%
Texas Pacific Land Trust (TPL)	2010-2016	906.58%
Genmab A-S (GMAB)	2010-2016	892.97%
American Airlines (AAL)	2010-2016	888.8%
Dycom Industries (DY)	2010-2016	887.58%
Constellation Brands Inc Class A (STZ)	2010-2016	873.48%
Manhattan Associates (MANH)	2010-2016	771.85%
XPO Logistics (XPO)	2010-2016	729.84%
Charter Communications (CHTR)	2010-2016	722.63%
Transdigm (TDG)	2010-2016	722.51%
U-Haul (UHAL)	2010-2016	691.22%
NXP Semiconductors (NXPI)	2010-2016	653.93%
DexCom (DXCM)	2010-2016	627.16%

Large-cap stocks are treated as having a market cap of $10B+.