QXO (QXO) had the highest return between 2010 and 2016 by a large-cap US stock, returning 3,450,050%.

ASSET	YEARS	% RETURN
QXO (QXO)	2010-2016	3,450,050%
Domino's Pizza Inc Common Stock (DPZ)	2010-2016	2,016.96%
Cheniere Energy (LNG)	2010-2016	1,557.18%
Netflix (NFLX)	2010-2016	1,460.96%
Regeneron Pharmaceuticals (REGN)	2010-2016	1,414.4%
Neurocrine Biosciences (NBIX)	2010-2016	1,297.11%
Jazz Pharmaceuticals (JAZZ)	2010-2016	1,252.73%
Ulta Beauty (ULTA)	2010-2016	1,240.58%
Tesla (TSLA)	2010-2016	1,024.65%
Incyte (INCY)	2010-2016	987.53%
United Rentals (URI)	2010-2016	964.32%
Broadcom (AVGO)	2010-2016	964.3%
Texas Pacific Land Trust (TPL)	2010-2016	906.56%
Genmab A-S (GMAB)	2010-2016	892.97%
Dycom Industries (DY)	2010-2016	887.58%
Constellation Brands Inc Class A (STZ)	2010-2016	873.49%
XPO Logistics (XPO)	2010-2016	729.84%
Charter Communications (CHTR)	2010-2016	722.63%
Transdigm (TDG)	2010-2016	722.51%
NXP Semiconductors (NXPI)	2010-2016	653.93%
DexCom (DXCM)	2010-2016	627.16%
Tyler Technologies (TYL)	2010-2016	612.07%
O’Reilly Automotive (ORLY)	2010-2016	609.4%
Monster Beverage (MNST)	2010-2016	588.17%
Booking (BKNG)	2010-2016	559.44%

Large-cap stocks are treated as having a market cap of $10B+.