Monster Beverage (MNST) had the highest return between 2003 and 2008 by a large-cap US stock, returning 6,264.9%.

ASSET	YEARS	% RETURN
Monster Beverage (MNST)	2003-2008	6,264.92%
Deckers Outdoor (DECK)	2003-2008	2,312.83%
Banco Bradesco SA ADR (BBD)	2003-2008	1,855.99%
Axon Enterprise (AXON)	2003-2008	1,464.44%
Illumina (ILMN)	2003-2008	1,427.82%
ArcelorMittal SA ADR (MT)	2003-2008	1,255.26%
Grupo Cibest (CIB)	2003-2008	1,194.77%
Apple (AAPL)	2003-2008	1,088.9%
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2003-2008	1,035.83%
Chunghwa Telecom (CHT)	2003-2008	996.6%
Williams Companies (WMB)	2003-2008	966.75%
Southern Copper (SCCO)	2003-2008	951%
Intuitive Surgical (ISRG)	2003-2008	932.49%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2003-2008	829.44%
Alamos Gold (AGI)	2003-2008	774.31%
Vale SA ADR (VALE)	2003-2008	744.8%
Akamai Technologies (AKAM)	2003-2008	738.33%
Stifel Financial (SF)	2003-2008	726.11%
U-Haul (UHAL)	2003-2008	676.74%
Itau Unibanco Banco (ITUB)	2003-2008	671.69%
Elbit Systems (ESLT)	2003-2008	663.3%
Booking (BKNG)	2003-2008	657.72%
NetEase (NTES)	2003-2008	654.92%
America Movil SAB de CV ADR (AMX)	2003-2008	600.55%
Ambev SA ADR (ABEV)	2003-2008	590.03%

Large-cap stocks are treated as having a market cap of $10B+.