Natwest (NWG) had the highest return between 2004 and 2007 by a US stock with a market cap of $50B+, returning 9,034,940%.

ASSET	YEARS	% RETURN
Natwest (NWG)	2004-2007	9,034,940%
National Grid PLC ADR (NGG)	2004-2007	1,604,552.94%
Monster Beverage (MNST)	2004-2007	4,108.44%
Intuitive Surgical (ISRG)	2004-2007	1,788.89%
Apple (AAPL)	2004-2007	1,738.71%
CME (CME)	2004-2007	871.35%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2004-2007	859.31%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2004-2007	808.69%
America Movil SAB de CV ADR (AMX)	2004-2007	622.19%
Alphabet Inc Class A (GOOGL)	2004-2007	591.42%
Booking (BKNG)	2004-2007	536.34%
Southern Copper (SCCO)	2004-2007	532.6%
Valero Energy (VLO)	2004-2007	504.38%
Itau Unibanco Banco (ITUB)	2004-2007	497.42%
Canadian Natural Resources (CNQ)	2004-2007	492.46%
Cheniere Energy (LNG)	2004-2007	458.43%
Cummins (CMI)	2004-2007	450.93%
Wheaton Precious Metals (WPM)	2004-2007	447.44%
Mastercard (MA)	2004-2007	436.89%
Intercontinental Exchange (ICE)	2004-2007	393.59%
Williams Companies (WMB)	2004-2007	385.64%
Alnylam Pharmaceuticals (ALNY)	2004-2007	376.72%
Agnico Eagle Mines (AEM)	2004-2007	356.58%
Suncor Energy (SU)	2004-2007	343.31%
HDFC Bank Limited ADR (HDB)	2004-2007	335.58%