National Grid PLC ADR (NGG) had the highest return between 2004 and 2010 by a US stock with a market cap of $50B+, returning 1,128,370.6%.

ASSET	YEARS	% RETURN
National Grid PLC ADR (NGG)	2004-2010	1,128,370.59%
Natwest (NWG)	2004-2010	774,270%
Monster Beverage (MNST)	2004-2010	4,867.73%
Apple (AAPL)	2004-2010	2,894.22%
Booking (BKNG)	2004-2010	2,113.57%
Intuitive Surgical (ISRG)	2004-2010	1,407.31%
Wheaton Precious Metals (WPM)	2004-2010	1,159.4%
Southern Copper (SCCO)	2004-2010	918.21%
Cummins (CMI)	2004-2010	898.1%
Salesforce (CRM)	2004-2010	780.02%
Itau Unibanco Banco (ITUB)	2004-2010	642.8%
Canadian Natural Resources (CNQ)	2004-2010	635.1%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2004-2010	627.72%
America Movil SAB de CV ADR (AMX)	2004-2010	606.59%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2004-2010	598.09%
Agnico Eagle Mines (AEM)	2004-2010	547.11%
Novo Nordisk A-S (NVO)	2004-2010	515.81%
Netflix (NFLX)	2004-2010	511.14%
Alphabet Inc Class A (GOOGL)	2004-2010	493.92%
BHP (BHP)	2004-2010	486.86%
HDFC Bank Limited ADR (HDB)	2004-2010	467.19%
Mastercard (MA)	2004-2010	464.19%
Altria (MO)	2004-2010	419.25%
CME (CME)	2004-2010	383.98%
Chipotle Mexican Grill (CMG)	2004-2010	372.58%