XORTX Therapeutics (XRTX) had the highest return between 2021 and 2022 by a US stock, returning 1,035,469.6%.

ASSET	YEARS	% RETURN
XORTX Therapeutics (XRTX)	2021-2022	1,035,469.62%
MDxHealth SA ADR (MDXH)	2021-2022	600,809.09%
Heart Test Laboratories Inc Common Stock (HSCS)	2021-2022	246,958.82%
Next Technology (NXTT)	2021-2022	202,803.23%
Applied Digital (APLD)	2021-2022	29,106.35%
Castellum (CTM)	2021-2022	28,536.36%
authID (AUID)	2021-2022	26,069.49%
Guardforce AI (GFAI)	2021-2022	24,323.08%
Bone Biologics (BBLG)	2021-2022	3,932%
Destination XL (DXLG)	2021-2022	2,476.34%
Vivid Seats (SEAT)	2021-2022	1,362.9%
Alpha Metallurgical Resources (AMR)	2021-2022	1,245.02%
Sigma Lithium Resources (SGML)	2021-2022	1,028.8%
Peabody Energy (BTU)	2021-2022	973.99%
Obsidian Energy (OBE)	2021-2022	891.04%
Hudson Technologies (HDSN)	2021-2022	854.72%
Target Hospitality (TH)	2021-2022	846.25%
Atlas Lithium Corporation Common Stock (ATLX)	2021-2022	833.33%
Empire Petroleum (EP)	2021-2022	831.82%
Birks (BGI)	2021-2022	822.09%
Weatherford International (WFRD)	2021-2022	757.97%
Permian Basin Royalty Trust (PBT)	2021-2022	750.3%
Baytex Energy (BTE)	2021-2022	719.87%
CPI Card (PMTS)	2021-2022	713.53%
Aehr Test Systems (AEHR)	2021-2022	704%