Brook Lopez has his most career points per game versus the Lakers, with 20.9 per game.

brook lopez highest career ppg by opponent
LALPORTORDALCHANYKOKCDETMILHOUCHIATLCLEINDLACWASDENPHXMIABOSPHIGSW20.919.318.418.318.118.117.717.217.116.816.716.516.516.516.416.416.115.915.915.815.815.6
OPPGPPPGMPGRPGAPGSPGBPGTPGFGMFGAFG%3PM3PA3P%FTMFTAFT%MINPTSREBASTSTLBLKTOVPF+/-
LakersLakers
2020.934.28.31.90.72.02.17.815.649.70.92.534.74.56.075.06854171653713394162-49
Trail BlazersTrail Blazers
2319.330.35.71.50.81.11.47.813.756.80.92.338.92.93.581.56984451313419263366+72
RaptorsRaptors
3618.431.46.51.40.62.01.97.114.349.60.61.930.93.64.382.71,13066223351207269101-102
MavericksMavericks
2518.330.56.81.50.61.11.27.114.449.61.12.740.33.04.075.87624581703715283063+46
HornetsHornets
3418.130.76.41.90.61.72.16.913.551.30.72.133.83.64.383.61,0446162166520597198+88
KnicksKnicks
4018.130.76.91.70.72.61.87.114.050.80.82.135.33.13.980.01,22772427468281027298+27
ThunderThunder
2417.730.36.41.00.81.71.86.813.949.11.12.939.12.93.484.17274241542419404260+32
PistonsPistons
3717.230.16.71.80.42.11.46.612.054.71.12.839.42.93.681.81,1146352476715785298+181
BucksBucks
2817.131.76.31.70.42.01.96.412.451.70.51.242.43.75.074.38874781754812575369-174
RocketsRockets
2316.829.56.81.30.62.62.06.412.153.00.51.433.33.54.282.56783871563113594656-52
BullsBulls
3916.730.56.11.20.51.81.36.513.348.60.72.428.73.13.783.91,19065123646217151102+56
HawksHawks
4116.530.25.91.40.51.61.86.312.450.91.02.538.83.03.780.31,2396782425822647394-75
CavaliersCavaliers
3616.531.77.01.60.61.61.46.212.649.20.92.140.83.34.278.11,1425952535820575299+135
PacersPacers
3716.529.96.31.40.71.81.86.213.247.40.72.131.63.44.377.51,1086112325126666594+7
ClippersClippers
2316.431.65.91.60.62.01.36.612.851.40.82.434.52.43.178.97273771353714463162+77
WizardsWizards
3616.430.26.31.80.51.71.86.111.751.80.61.635.73.74.680.11,08758922666176166106+61
NuggetsNuggets
2416.128.65.41.60.31.01.76.112.449.01.02.639.72.93.778.7685387129388234174+9
SunsSuns
2515.931.46.91.00.51.72.06.113.146.50.72.826.13.03.879.27853981722613425169+33
HeatHeat
3615.929.96.11.10.51.51.55.912.547.50.82.238.53.24.079.71,0765722183817535582-11
CelticsCeltics
4115.830.65.81.10.41.71.96.012.348.50.51.826.03.54.283.01,2536492364718697787-40
76ers76ers
4215.830.46.31.50.41.71.95.912.447.51.02.736.53.03.781.31,27766426461187278118+212
WarriorsWarriors
2115.629.15.61.51.01.62.06.112.648.90.52.124.42.83.580.86123281183121344354-76
PelicansPelicans
2215.529.56.01.60.81.81.56.012.150.00.62.130.42.73.774.16483401323617393255+21
TimberwolvesTimberwolves
2315.429.66.91.40.72.02.06.111.353.81.02.638.32.23.368.06813541593317464565+50
KingsKings
2615.128.56.11.20.32.21.65.712.346.10.82.629.93.03.783.2741393159308574188+97
MagicMagic
3714.128.65.40.90.91.81.65.512.045.80.51.926.42.63.476.01,0595202003332666195-52
GrizzliesGrizzlies
2513.929.15.21.60.61.31.75.211.346.10.82.432.82.73.773.17273481304014324366-65
JazzJazz
2513.728.25.70.80.72.01.65.111.444.80.82.632.32.63.575.97063431432118494070-113
SpursSpurs
2413.629.46.01.60.51.51.45.011.045.20.51.731.73.13.686.27043261433912363460-194
NetsNets
1312.727.65.00.90.62.91.24.811.043.42.05.536.11.21.388.235816565128381630+73