Derrick Rose has scored his most career points per game against the Knicks, with 20.7 per game.

derrick rose highest career ppg by opponent

OPP	PPG	GP	MPG	RPG	APG	SPG	BPG	TPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	MIN	PTS	REB	AST	STL	BLK	TOV	PF	+/-
Knicks	20.7	22	32.2	3.5	5.3	1.1	0.2	3.0	8.2	17.6	46.5	0.9	2.6	33.3	3.5	4.5	77.6	709	455	76	117	25	4	65	24	-13
Jazz	20.6	18	32.3	2.7	5.9	0.6	0.3	3.3	7.9	15.9	49.5	1.2	2.7	43.8	3.6	4.5	80.2	581	370	48	107	10	5	60	26	-8
Thunder	20.5	13	32.8	3.9	5.0	0.7	0.2	2.5	8.7	17.8	48.7	0.2	1.2	12.5	2.9	3.2	90.5	426	266	51	65	9	2	33	26	+14
Wizards	20.1	28	32.2	3.1	5.0	1.0	0.4	2.8	7.7	16.6	46.4	1.0	3.1	33.3	3.7	4.3	85.8	903	564	86	139	29	11	77	26	+8
Clippers	19.7	17	31.8	3.9	6.2	0.5	0.4	2.7	7.8	15.6	49.6	0.8	2.1	40.0	3.4	3.9	85.1	541	335	66	105	9	7	46	17	+16
Suns	19.7	20	31.0	3.9	4.2	0.9	0.3	1.7	8.2	16.3	50.3	0.6	2.6	23.5	2.7	3.1	87.1	620	394	77	84	17	5	33	25	+23
Trail Blazers	19.5	13	34.8	3.2	5.8	1.0	0.2	3.1	8.1	17.8	45.5	0.4	2.2	17.9	3.0	3.6	83.0	453	254	42	76	13	2	40	23	-90
Lakers	19.5	21	31.0	3.7	5.0	0.6	0.3	2.6	7.7	16.1	47.5	1.1	2.7	41.1	3.1	3.5	87.8	652	410	77	106	12	6	54	21	-20
Hawks	19.0	32	31.4	3.7	5.5	0.5	0.3	2.8	7.3	17.0	43.1	1.0	3.0	33.7	3.3	4.2	79.7	1,005	608	118	177	15	10	89	42	-36
76ers	18.9	26	32.1	3.6	5.6	1.1	0.4	3.2	7.5	15.0	49.6	0.7	2.4	30.6	3.3	3.9	83.3	834	492	94	145	28	11	84	27	+100
Celtics	18.9	31	31.2	3.7	4.6	0.5	0.4	2.8	7.3	15.2	48.3	0.9	2.4	38.7	3.3	3.9	84.3	967	585	115	144	14	13	86	50	-60
Pistons	18.2	32	31.2	3.1	5.3	0.9	0.4	2.6	7.0	14.8	47.4	0.6	2.4	25.0	3.5	4.3	83.1	1,000	582	100	169	30	14	84	50	+175
Raptors	18.0	28	31.9	2.7	5.9	0.6	0.3	2.4	7.0	14.4	48.9	0.6	2.4	25.4	3.3	3.9	84.5	893	504	75	166	17	9	66	25	-10
Pacers	17.7	36	31.6	3.8	5.6	0.7	0.5	2.2	6.9	15.4	44.6	0.9	2.8	31.3	3.1	3.7	84.2	1,139	637	135	202	26	18	79	45	+72
Bucks	17.7	39	31.2	2.8	6.4	1.1	0.3	2.5	6.7	14.8	45.6	0.9	2.8	31.2	3.3	3.7	90.9	1,218	690	111	248	41	11	99	36	+183
Cavaliers	17.3	31	31.7	2.5	5.9	0.6	0.3	2.2	6.9	16.2	42.7	0.8	2.5	30.8	2.7	3.5	77.6	983	537	79	182	19	8	69	36	-81
Kings	17.3	19	29.6	3.4	6.6	0.6	0.2	2.5	6.4	13.3	48.4	0.7	1.9	36.1	3.7	4.4	84.5	562	328	64	125	12	3	48	31	+86
Grizzlies	16.9	16	30.3	3.9	4.9	0.8	0.5	2.1	6.8	15.2	44.4	0.4	2.6	16.7	3.0	3.5	85.7	486	271	62	79	13	8	34	17	+83
Nets	16.3	31	31.1	3.6	4.9	0.7	0.2	2.0	6.2	13.9	44.9	1.0	2.8	35.2	2.8	3.6	78.6	966	505	112	152	21	6	63	50	+37
Hornets	16.3	28	30.8	2.8	5.4	0.6	0.5	2.5	6.4	13.6	46.6	1.0	2.6	36.5	2.6	3.1	83.9	863	456	79	152	18	13	71	38	-38
Heat	16.3	25	31.0	3.0	4.0	0.9	0.3	2.3	6.1	15.1	40.2	0.6	2.6	24.6	3.5	4.3	80.6	775	407	76	100	22	7	57	25	-108
Warriors	16.2	21	29.4	2.5	4.9	0.7	0.3	2.9	6.5	15.2	42.5	0.9	3.2	26.9	2.4	2.7	91.1	618	341	53	103	14	7	61	32	-22
Spurs	16.2	24	26.9	2.6	4.2	0.5	0.3	1.5	6.5	14.0	46.3	0.7	2.0	35.4	2.6	2.9	89.9	645	389	63	101	13	8	35	22	+19
Pelicans	15.8	19	30.4	3.0	4.9	1.1	0.4	2.2	6.4	14.9	43.1	0.8	2.7	30.8	2.2	2.7	80.4	577	301	57	94	20	7	41	17	+154
Bulls	15.4	12	26.9	2.6	4.8	0.8	0.7	2.1	5.7	11.6	48.9	0.7	2.0	33.3	3.4	3.7	93.2	323	185	31	58	9	8	25	14	+57