I didn't find anything for this season, but Jayson Tatum scored his most points in a game in 2024-25 versus the Cavaliers on February 28, with 46 points.

Interpreted as:

highest scoring regular-season game Jayson Tatum this season

	NAME	PTS	DATE	TM		OPP	MIN	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF	+/-
1	Jayson Tatum J. Tatum	46	2/28/2025	BOS	vs	CLE	41	16	9	0	3	19	37	51.4	4	12	33.3	4	5	80.0	58.7	5	11	3	4	+5
2	Jayson Tatum J. Tatum	43	12/21/2024	BOS	@	CHI	36	15	10	0	0	16	24	66.7	9	15	60.0	2	2	100.0	86.4	1	14	4	2	+13
3	Jayson Tatum J. Tatum	40	3/8/2025	BOS	vs	LAL	45	12	8	2	1	12	28	42.9	6	16	37.5	10	12	83.3	60.1	1	11	3	3	+12
4	Jayson Tatum J. Tatum	40	2/8/2025	BOS	@	NYK	37	6	4	0	0	13	26	50.0	7	14	50.0	7	9	77.8	66.8	0	6	1	1	+18
5	Jayson Tatum J. Tatum	38	1/12/2025	BOS	vs	NOP	36	11	1	1	1	14	30	46.7	2	10	20.0	8	10	80.0	55.2	3	8	3	1	-9
6	Jayson Tatum J. Tatum	37	10/30/2024	BOS	@	IND	43	8	4	4	0	10	25	40.0	5	18	27.8	12	15	80.0	58.5	1	7	3	3	-7
7	Jayson Tatum J. Tatum	37	10/26/2024	BOS	@	DET	38	4	2	2	1	12	26	46.2	6	13	46.2	7	9	77.8	61.7	1	3	1	5	+1
8	Jayson Tatum J. Tatum	37	10/22/2024	BOS	vs	NYK	30	4	10	1	1	14	18	77.8	8	11	72.7	1	2	50.0	98.0	0	4	1	1	+26
9	Jayson Tatum J. Tatum	36	11/13/2024	BOS	@	BKN	35	9	10	0	0	12	19	63.2	5	6	83.3	7	9	77.8	78.4	1	8	1	3	+24
10	Jayson Tatum J. Tatum	35	3/6/2025	BOS	vs	PHI	31	7	2	3	0	14	23	60.9	5	11	45.5	2	2	100.0	73.3	1	6	4	2	+19
11	Jayson Tatum J. Tatum	35	2/2/2025	BOS	@	PHI	44	7	11	1	1	13	20	65.0	5	8	62.5	4	5	80.0	78.8	0	7	3	3	+2
12	Jayson Tatum J. Tatum	35	11/29/2024	BOS	@	CHI	36	14	5	1	1	12	18	66.7	4	8	50.0	7	10	70.0	78.1	1	13	3	0	+13
13	Jayson Tatum J. Tatum	34	12/6/2024	BOS	vs	MIL	37	10	5	0	0	12	20	60.0	4	10	40.0	6	8	75.0	72.3	1	9	1	4	+14
14	Jayson Tatum J. Tatum	33	3/12/2025	BOS	vs	OKC	41	8	8	0	0	12	23	52.2	4	13	30.8	5	5	100.0	65.5	2	6	4	2	+4
15	Jayson Tatum J. Tatum	33	2/10/2025	BOS	@	MIA	38	8	2	0	1	13	26	50.0	4	12	33.3	3	3	100.0	60.4	0	8	0	1	+6
16	Jayson Tatum J. Tatum	33	1/2/2025	BOS	@	MIN	38	8	9	3	0	13	27	48.1	6	17	35.3	1	2	50.0	59.2	0	8	2	2	+3
17	Jayson Tatum J. Tatum	33	12/1/2024	BOS	@	CLE	38	8	4	1	1	12	27	44.4	4	9	44.4	5	5	100.0	56.5	0	8	2	2	+1
18	Jayson Tatum J. Tatum	33	11/19/2024	BOS	vs	CLE	38	12	7	2	0	11	22	50.0	6	10	60.0	5	7	71.4	65.8	0	12	4	3	+2
19	Jayson Tatum J. Tatum	33	11/8/2024	BOS	vs	BKN	42	9	6	2	1	11	25	44.0	5	13	38.5	6	7	85.7	58.8	0	9	3	3	+10
20	Jayson Tatum J. Tatum	32	4/8/2025	BOS	@	NYK	48	7	5	1	1	11	22	50.0	4	11	36.4	6	8	75.0	62.7	0	7	2	2	+2
21	Jayson Tatum J. Tatum	32	2/12/2025	BOS	vs	SAS	38	14	7	0	1	12	25	48.0	4	14	28.6	4	8	50.0	56.1	1	13	2	3	+12
22	Jayson Tatum J. Tatum	32	12/25/2024	BOS	vs	PHI	42	15	4	1	1	11	20	55.0	4	8	50.0	6	7	85.7	69.3	2	13	3	2	+5
23	Jayson Tatum J. Tatum	32	11/6/2024	BOS	vs	GSW	37	4	2	1	1	10	20	50.0	5	10	50.0	7	9	77.8	66.8	0	4	4	3	-5
24	Jayson Tatum J. Tatum	32	11/1/2024	BOS	@	CHA	36	11	3	3	1	9	19	47.4	3	9	33.3	11	13	84.6	64.7	1	10	5	1	+16
25	Jayson Tatum J. Tatum	31	12/19/2024	BOS	vs	CHI	37	10	4	2	0	10	22	45.5	4	11	36.4	7	9	77.8	59.7	0	10	1	4	0