Wilt Chamberlain has posted the most points in a game on Fridays, with 100 points against the Knicks on March 2, 1962.

Interpreted as:

highest single regular-season game points by a player on a friday

	NAME	PTS	DATE	TM		OPP	MIN	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF	+/-
1	Wilt Chamberlain W. Chamberlain	100	3/2/1962	PHI		NYK	48	25	2			36	63	57.1				28	32	87.5	64.9				2
2	Wilt Chamberlain W. Chamberlain	78	12/8/1961	PHI	vs	LAL	63	43	1			31	62	50.0				16	31	51.6	51.6				4
3	Luka Dončić L. Dončić	73	1/26/2024	DAL	@	ATL	45	10	7	1	0	25	33	75.8	8	13	61.5	15	16	93.8	91.2	0	10	4	1	+13
4	Wilt Chamberlain W. Chamberlain	73	11/16/1962	SFW	@	NYK	48	14	1			29	43	67.4				15	19	78.9	71.1				0
5	Devin Booker D. Booker	70	3/24/2017	PHX	@	BOS	45	8	6	3	1	21	40	52.5	4	11	36.4	24	26	92.3	68.0	2	6	5	3	-6
6	Pete Maravich P. Maravich	68	2/25/1977	NOJ	vs	NYK	43	6	6	3	2	26	43	60.5				16	19	84.2	66.2	1	5		6
7	Wilt Chamberlain W. Chamberlain	67	1/11/1963	SFW	vs	LAL	48	25	1			28	47	59.6				11	17	64.7	61.5				1
8	Kobe Bryant K. Bryant	65	3/16/2007	LAL	vs	POR	50	7	3	3	0	23	39	59.0	8	12	66.7	11	12	91.7	73.4	1	6	2	3	+4
9	Wilt Chamberlain W. Chamberlain	63	12/14/1962	SFW	vs	LAL	48	30	1			24	41	58.5				15	20	75.0	63.3				4
10	Elgin Baylor E. Baylor	63	12/8/1961	LAL	@	PHI		31	7			23	55	41.8				17	24	70.8	48.0				4
11	Devin Booker D. Booker	62	1/26/2024	PHX	@	IND	38	5	4	1	2	22	37	59.5	6	12	50.0	12	13	92.3	72.6	0	5	4	2	+1
12	Carmelo Anthony C. Anthony	62	1/24/2014	NYK	vs	CHA	39	13	0	0	0	23	35	65.7	6	11	54.5	10	10	100.0	78.7	1	12	0	1	+34
13	Jalen Brunson J. Brunson	61	3/29/2024	NYK	@	SAS	43	4	6	1	0	25	47	53.2	5	13	38.5	6	6	100.0	61.4	1	3	1	2	+20
14	James Harden J. Harden	61	3/22/2019	HOU	vs	SAS	37	7	1	3	0	19	34	55.9	9	13	69.2	14	17	82.4	73.5	2	5	3	3	+18
15	De'Aaron Fox D. Fox	60	11/15/2024	SAC	vs	MIN	44	3	7	3	1	22	35	62.9	6	10	60.0	10	11	90.9	75.3	2	1	6	3	+1
16	Jayson Tatum J. Tatum	60	4/30/2021	BOS	vs	SAS	45	8	5	0	1	20	37	54.1	5	7	71.4	15	17	88.2	67.4	2	6	0	2	+6
17	Damian Lillard D. Lillard	60	11/8/2019	POR	vs	BKN	40	4	5	0	0	19	33	57.6	7	16	43.8	15	15	100.0	75.8	0	4	2	1	+4
18	Wilt Chamberlain W. Chamberlain	60	12/29/1961	PHI		LAL	48	26	3			24	43	55.8				12	19	63.2	58.4				1
19	Wilt Chamberlain W. Chamberlain	60	12/1/1961	PHI	@	LAL	48	21	4			22	47	46.8				16	26	61.5	51.3				1
20	Wilt Chamberlain W. Chamberlain	59	12/6/1963	SFW	vs	LAL	48	27	4			22	45	48.9				15	29	51.7	51.1				1
21	Jack Twyman J. Twyman	59	1/15/1960	CIN	vs	MIN		14				21	39	53.8				17	20	85.0	61.7				3
22	Kobe Bryant K. Bryant	58	12/29/2006	LAL	@	CHA	54	5	4	0	0	22	45	48.9	4	11	36.4	10	12	83.3	57.7	0	5	4	6	+5
23	LeBron James L. James	57	11/3/2017	CLE	@	WAS	43	11	7	3	2	23	34	67.6	2	4	50.0	9	9	100.0	75.1	5	6	3	2	+6
24	Wilt Chamberlain W. Chamberlain	57	10/20/1961	PHI	vs	LAL	48	32	1			24	46	52.2				9	17	52.9	53.3				2
25	Richie Guerin R. Guerin	57	12/11/1959	NYK	vs	SYR	38	12	8			18	31	58.1				21	26	80.8	67.2				1