Kobe Bryant had his most points in a game versus Dwyane Wade on December 25, 2004, with 42 points.

Interpreted as:

Kobe Bryant most points in a regular-season game vs dwayne wade

	NAME	PTS	DATE	TM		OPP	MIN	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF	+/-
1	Kobe Bryant K. Bryant	42	12/25/2004	LAL	vs	MIA	50	3	6	1	0	12	30	40.0	5	13	38.5	13	13	100.0	58.8	0	3	9	4	0
2	Kobe Bryant K. Bryant	39	3/4/2010	LAL	@	MIA	46	2	4	1	1	15	28	53.6	2	7	28.6	7	10	70.0	60.2	0	2	2	3	+3
3	Kobe Bryant K. Bryant	37	1/16/2006	LAL	vs	MIA	41	3	4	1	0	13	24	54.2	2	5	40.0	9	9	100.0	66.2	0	3	1	3	+14
4	Kobe Bryant K. Bryant	37	12/25/2005	LAL	@	MIA	44	8	6	0	2	12	30	40.0	0	8	0.0	13	19	68.4	48.2	2	6	3	5	+1
5	Kobe Bryant K. Bryant	33	3/4/2012	LAL	vs	MIA	39	3	1	0	0	14	23	60.9	0	2	0.0	5	7	71.4	63.3	1	2	3	0	+8
6	Kobe Bryant K. Bryant	33	12/4/2009	LAL	vs	MIA	42	7	3	3	0	12	25	48.0	2	3	66.7	7	8	87.5	57.9	3	4	2	5	+4
7	Kobe Bryant K. Bryant	33	2/10/2008	LAL	@	MIA	42	3	5	2	0	10	15	66.7	2	5	40.0	11	11	100.0	83.2	0	3	4	4	+7
8	Kobe Bryant K. Bryant	28	2/10/2013	LAL	@	MIA	37	6	9	1	0	11	19	57.9	0	0		6	8	75.0	62.2	1	5	4	2	-14
9	Kobe Bryant K. Bryant	28	12/19/2008	LAL	@	MIA	36	3	3	0	0	12	24	50.0	1	3	33.3	3	4	75.0	54.3	1	2	5	3	-6
10	Kobe Bryant K. Bryant	27	11/16/2003	LAL	vs	MIA	34	4	6	2	0	6	10	60.0	0	1	0.0	15	16	93.8	79.2	1	3	3	2	+21
11	Kobe Bryant K. Bryant	26	3/17/2005	LAL	@	MIA	46	10	3	4	1	8	23	34.8	2	6	33.3	8	9	88.9	48.2	5	5	3	2	-6
12	Kobe Bryant K. Bryant	25	1/15/2007	LAL	vs	MIA	44	4	8	0	1	11	24	45.8	0	2	0.0	3	3	100.0	49.4	1	3	1	2	+2
13	Kobe Bryant K. Bryant	24	3/10/2011	LAL	@	MIA	40	2	2	1	0	8	21	38.1	4	8	50.0	4	5	80.0	51.7	0	2	3	3	+3
14	Kobe Bryant K. Bryant	22	1/17/2013	LAL	vs	MIA	43	4	1	1	0	8	25	32.0	4	9	44.4	2	2	100.0	42.5	1	3	6	4	-9
15	Kobe Bryant K. Bryant	21	2/28/2008	LAL	vs	MIA	41	1	8	4	2	7	14	50.0	0	2	0.0	7	7	100.0	61.5	0	1	3	5	+14
16	Kobe Bryant K. Bryant	19	1/11/2009	LAL	vs	MIA	37	2	7	0	0	5	14	35.7	2	4	50.0	7	7	100.0	55.6	0	2	4	3	+11
17	Kobe Bryant K. Bryant	17	12/25/2010	LAL	vs	MIA	40	6	7	1	0	6	16	37.5	1	3	33.3	4	5	80.0	46.7	1	5	4	5	-21
18	Kobe Bryant K. Bryant	16	12/25/2006	LAL	@	MIA	38	2	4	1	0	4	17	23.5	0	4	0.0	8	9	88.9	38.2	0	2	3	4	-19
19	Kobe Bryant K. Bryant	12	1/13/2015	LAL	vs	MIA	31	6	7	1	0	3	19	15.8	2	9	22.2	4	4	100.0	28.9	0	6	2	0	-6
20	Kobe Bryant K. Bryant	2	3/30/2016	LAL	vs	MIA	9	2	0	0	0	1	7	14.3	0	2	0.0	0	0		14.3	1	1	1	0	-13