Since 1999-00, Kobe Bryant has the most games with 40+ points, with 122 games.

Interpreted as:

most 40 or more points regular-season game by a player since 2000

	NAME	GP	PTS	MPG	PPG	RPG	APG	SPG	BPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TPG	MIN	REB	AST	STL	BLK	TOV	PF	+/-
1	Kobe Bryant K. Bryant	122	5,501	42.8	45.1	6.1	4.2	1.8	0.6	15.4	30.1	51.1	2.9	6.6	43.8	11.4	13.3	85.7	62.7	1.2	4.9	3.2	5,218	741	512	214	74	396	334	+759
2	James Harden J. Harden	107	4,854	39.5	45.4	7.4	8.1	2.1	0.7	13.3	26.2	50.8	5.6	12.8	44.2	13.1	14.9	87.9	69.2	1.2	6.2	4.8	4,226	788	869	228	79	516	318	+1074
3	LeBron James L. James	79	3,517	41.6	44.5	8.7	7.1	1.7	0.9	15.7	26.6	59.0	3.8	7.3	51.2	9.3	11.8	79.4	70.0	1.6	7.1	3.7	3,286	684	560	136	73	289	145	+651
4	Stephen Curry S. Curry	74	3,352	36.4	45.3	5.3	5.6	1.4	0.3	14.9	25.4	58.5	8.5	15.2	56.1	7.0	7.6	92.9	78.8	0.7	4.7	3.4	2,693	395	416	103	23	248	150	+870
5	Kevin Durant K. Durant	72	3,143	41.4	43.7	8.1	4.6	1.2	1.2	14.8	25.9	57.2	3.8	7.8	48.5	10.2	11.4	89.4	70.5	0.9	7.2	3.8	2,984	584	332	84	86	270	171	+412
6	Allen Iverson A. Iverson	71	3,159	44.9	44.5	4.2	6.2	2.4	0.2	15.6	30.5	51.0	1.8	4.6	39.7	11.5	13.7	84.2	60.9	0.9	3.3	3.6	3,188	300	439	172	13	257	153	+502
7	Damian Lillard D. Lillard	60	2,713	39.3	45.2	4.9	7.3	1.2	0.3	14.1	25.3	55.7	6.5	12.9	50.2	10.6	11.5	92.6	74.5	0.6	4.3	2.6	2,356	293	438	71	20	156	115	+423
8	Giannis Antetokounmpo G. Antetokounmpo	56	2,514	36.6	44.9	13.0	5.5	1.2	1.2	16.5	25.1	65.9	1.3	3.4	39.1	10.5	14.6	72.2	71.3	2.8	10.2	3.3	2,048	728	306	65	69	183	158	+374
9	Luka Dončić L. Dončić	51	2,270	38.8	44.5	9.7	9.1	1.5	0.5	15.0	26.4	57.0	4.9	10.8	45.7	9.5	12.0	79.3	70.3	0.9	8.8	3.8	1,977	495	465	79	23	195	139	+433
10	Russell Westbrook R. Westbrook	50	2,212	39.0	44.2	9.8	8.3	1.6	0.3	15.5	30.1	51.6	3.1	7.8	40.2	10.1	12.2	82.6	62.4	2.0	7.9	5.0	1,949	491	417	78	15	251	141	+74
11	Joel Embiid J. Embiid	48	2,134	36.2	44.5	13.4	4.4	1.3	2.0	15.0	24.8	60.5	1.5	3.8	38.0	13.0	15.0	86.7	70.8	2.9	10.5	3.3	1,736	641	213	60	97	157	156	+533
12	Anthony Davis A. Davis	45	1,966	39.5	43.7	13.9	2.9	1.8	2.1	15.8	27.0	58.6	1.3	3.2	42.0	10.7	12.4	86.5	67.4	3.8	10.1	1.9	1,777	627	131	82	93	84	110	+385
13	Tracy McGrady T. McGrady	45	1,987	41.8	44.2	7.7	5.1	1.7	0.9	15.7	29.5	53.4	3.5	7.4	47.1	9.2	11.9	77.4	63.6	1.8	5.9	2.9	1,880	347	228	78	41	129	88	+219
14	Devin Booker D. Booker	37	1,711	38.0	46.2	5.3	5.9	1.2	0.5	16.4	27.5	59.8	3.9	8.5	46.3	9.4	10.7	88.4	71.9	0.8	4.5	3.5	1,405	197	219	45	18	130	107	+295
15	Kyrie Irving K. Irving	37	1,657	39.4	44.8	4.7	5.5	1.8	0.5	15.9	26.8	59.4	5.7	10.0	56.9	7.2	7.9	91.2	73.9	0.8	3.9	2.7	1,458	173	203	66	19	100	98	+292
16	Carmelo Anthony C. Anthony	36	1,586	42.3	44.1	7.6	2.9	1.2	0.6	15.9	27.6	57.7	3.0	5.6	53.2	9.2	10.6	86.4	68.2	2.1	5.4	2.5	1,521	272	103	42	22	91	130	+169
17	Trae Young T. Young	34	1,487	38.1	43.7	4.2	9.1	1.1	0.1	13.7	25.6	53.6	5.2	11.0	47.1	11.1	12.6	88.1	70.2	0.8	3.4	4.8	1,294	142	310	39	5	164	57	+156
18	Dwyane Wade D. Wade	34	1,467	41.9	43.1	6.2	6.2	2.5	1.4	15.0	26.4	56.8	1.6	3.8	43.4	11.4	14.1	81.2	66.1	1.4	4.8	3.9	1,426	212	212	84	48	134	81	+212
19	Nikola Jokić N. Jokić	33	1,454	38.5	44.1	12.2	7.8	1.8	1.0	16.6	27.1	61.2	2.6	5.9	44.1	8.3	10.0	82.8	69.9	3.5	8.6	3.1	1,270	402	257	58	32	102	93	+307
20	Donovan Mitchell D. Mitchell	32	1,397	38.9	43.7	5.5	4.9	1.4	0.3	15.1	27.9	54.0	5.3	11.8	44.9	8.3	9.4	87.7	68.2	1.1	4.5	3.2	1,246	177	157	46	11	101	75	+289
21	Vince Carter V. Carter	32	1,396	42.6	43.6	7.6	4.3	1.6	0.9	15.1	27.6	54.8	4.0	7.5	53.5	9.3	11.1	84.5	67.2	2.3	5.3	2.8	1,363	243	138	52	30	90	105	+270
22	Bradley Beal B. Beal	31	1,378	40.8	44.5	4.8	5.5	1.2	0.4	15.8	28.0	56.5	4.6	9.4	48.6	8.3	9.6	86.2	69.0	1.4	3.4	3.1	1,265	148	169	36	12	96	80	+29
23	Jayson Tatum J. Tatum	29	1,282	39.0	44.2	8.6	4.7	0.9	0.8	14.6	25.6	57.1	5.9	11.2	52.8	9.1	10.2	88.9	73.5	1.0	7.7	2.1	1,131	250	135	27	22	62	65	+391
24	Gilbert Arenas G. Arenas	29	1,277	42.7	44.0	4.0	5.7	1.9	0.2	13.7	25.5	53.7	4.7	9.6	48.6	12.0	14.4	83.1	69.1	1.0	3.0	3.9	1,238	117	165	56	7	114	97	+162
25	Shai Gilgeous-Alexander S. Gilgeous-Alexander	28	1,226	36.9	43.8	5.6	5.9	1.9	1.1	14.6	24.8	58.9	2.4	5.1	46.2	12.2	13.5	90.5	71.3	0.9	4.8	2.3	1,032	157	164	54	32	64	72	+377