most points in one game against the pistons by a current player in their career

Giannis Antetokounmpo and Anthony Davis are tied for the most points by an active player in a game against the Pistons, with 59 points.

Interpreted as:

most points in one regular-season game against the pistons by a current player in their career

	NAME	PTS	DATE	TM		OPP	MIN	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF	+/-
1	Giannis Antetokounmpo G. Antetokounmpo	59	11/13/2024	MIL	vs	DET	44	14	7	2	3	21	34	61.8	1	2	50.0	16	17	94.1	71.1	3	11	3	1	+7
2	Anthony Davis A. Davis	59	2/21/2016	NOP	@	DET	43	20	4	0	1	24	34	70.6	2	2	100.0	9	10	90.0	76.8	6	14	2	1	+17
3	Anthony Edwards A. Edwards	53	1/4/2025	MIN	@	DET	44	6	2	0	0	16	31	51.6	10	15	66.7	11	12	91.7	73.0	1	5	6	4	-3
4	Luka Dončić L. Dončić	53	1/30/2023	DAL	vs	DET	36	8	5	2	0	17	24	70.8	5	11	45.5	14	18	77.8	83.0	0	8	4	2	+8
5	Zach LaVine Z. LaVine	51	10/28/2023	CHI	@	DET	37	5	0	1	0	19	33	57.6	7	13	53.8	6	8	75.0	69.8	2	3	4	2	-8
6	Kevin Durant K. Durant	51	12/12/2021	BKN	@	DET	41	7	9	1	2	16	31	51.6	5	10	50.0	14	15	93.3	67.8	0	7	5	5	+25
7	James Harden J. Harden	50	3/5/2025	LAC	vs	DET	38	4	5	1	1	14	24	58.3	6	13	46.2	16	20	80.0	76.2	0	4	5	2	+13
8	Jerami Grant J. Grant	49	2/8/2024	POR	vs	DET	45	8	6	0	0	14	29	48.3	3	6	50.0	18	20	90.0	64.8	2	6	4	5	-5
9	Desmond Bane D. Bane	49	12/6/2023	MEM	@	DET	36	6	8	1	2	19	31	61.3	4	8	50.0	7	7	100.0	71.9	1	5	3	2	-1
10	Shai Gilgeous-Alexander S. Gilgeous-Alexander	48	3/15/2025	OKC	@	DET	38	4	6	3	1	17	26	65.4	4	6	66.7	10	10	100.0	78.9	0	4	2	1	+18
11	Donovan Mitchell D. Mitchell	45	1/31/2024	CLE	vs	DET	35	6	8	2	1	14	25	56.0	6	13	46.2	11	12	91.7	74.3	2	4	2	2	+22
12	Damian Lillard D. Lillard	45	1/20/2024	MIL	@	DET	37	6	11	1	0	12	22	54.5	5	11	45.5	16	16	100.0	77.5	0	6	1	3	+18
13	Kyrie Irving K. Irving	45	1/25/2020	BKN	@	DET	40	6	7	0	0	15	30	50.0	5	12	41.7	10	10	100.0	65.4	0	6	1	5	+13
14	James Harden J. Harden	44	3/26/2021	BKN	@	DET	42	14	8	1	0	14	30	46.7	4	11	36.4	12	14	85.7	60.8	2	12	3	6	-3
15	Pat Connaughton P. Connaughton	43	4/13/2025	MIL	vs	DET	44	11	5	2	0	16	29	55.2	5	12	41.7	6	9	66.7	65.2	1	10	2	2	+7
16	Zach LaVine Z. LaVine	43	4/7/2025	SAC	@	DET	45	3	4	1	0	16	28	57.1	8	11	72.7	3	4	75.0	72.2	0	3	1	4	+6
17	Kevin Durant K. Durant	43	12/21/2024	PHX	vs	DET	39	5	6	2	0	14	26	53.8	4	9	44.4	11	11	100.0	69.7	1	4	8	4	-9
18	Zach LaVine Z. LaVine	43	12/30/2022	CHI	vs	DET	38	3	6	2	0	15	20	75.0	5	9	55.6	8	8	100.0	91.4	0	3	4	1	+19
19	Kevin Durant K. Durant	43	12/18/2022	BKN	@	DET	36	6	2	1	2	14	22	63.6	3	5	60.0	12	13	92.3	77.6	1	5	6	3	-3
20	Jayson Tatum J. Tatum	43	11/12/2022	BOS	@	DET	41	10	3	1	1	14	28	50.0	7	14	50.0	8	10	80.0	66.4	2	8	3	2	+7
21	Norman Powell N. Powell	43	3/17/2021	TOR	@	DET	38	3	0	0	0	14	18	77.8	8	12	66.7	7	9	77.8	97.9	1	2	2	4	-11
22	Giannis Antetokounmpo G. Antetokounmpo	43	1/4/2021	MIL	vs	DET	36	9	4	0	1	17	24	70.8	2	6	33.3	7	9	77.8	76.9	2	7	3	4	+16
23	James Harden J. Harden	43	11/21/2018	HOU	vs	DET	36	7	9	4	0	10	20	50.0	4	9	44.4	19	19	100.0	75.8	1	6	6	3	+9
24	Jimmy Butler III J. Butler III	43	12/18/2015	CHI	vs	DET	56	8	2	2	2	14	29	48.3	1	4	25.0	14	16	87.5	59.7	1	7	3	5	-5
25	LeBron James L. James	43	11/24/2004	CLE	vs	DET	38	6	5	3	1	15	22	68.2	2	3	66.7	11	12	91.7	78.8	3	3	3	3	+12