Wilt Chamberlain had the most games with 53+ points, with 92 games.

Interpreted as:

NBA most 53 or more point regular-season games by a player

	NAME	GP	PTS	MPG	PPG	RPG	APG	SPG	BPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TPG	MIN	REB	AST	STL	BLK	TOV	PF	+/-
1	Wilt Chamberlain W. Chamberlain	92	5,445		59.2	26.6				24.2	42.7	56.5				10.9	17.9	60.7	58.5					2,443					149
2	Michael Jordan M. Jordan	15	860	42.9	57.3	8.4	4.7	3.5	1.3	21.1	33.9	62.2	1.1	2.4	44.4	14.1	16.2	87.2	69.9	2.6	5.8	3.0	643	126	71	52	19	45	48
3	James Harden J. Harden	14	803	40.1	57.4	7.5	8.4	2.4	0.9	17.5	31.7	55.2	7.4	15.4	48.1	14.9	16.3	91.7	73.8	1.6	5.9	5.2	562	105	117	34	12	73	44	+214
4	Kobe Bryant K. Bryant	12	717	43.5	59.8	5.6	3.2	1.6	0.3	20.3	38.4	52.7	5.3	11.1	48.1	13.9	15.5	89.8	66.0	1.2	4.4	2.4	522	67	38	19	4	29	32	+180
5	Stephen Curry S. Curry	7	395	38.4	56.4	4.7	5.1	1.4	0.1	17.7	29.1	60.8	10.0	17.4	57.4	11.0	11.3	97.5	82.7	0.3	4.4	3.6	269	33	36	10	1	25	13	+69
6	Damian Lillard D. Lillard	6	372	41.2	62.0	6.3	6.5	1.0	0.2	19.0	33.8	56.2	9.7	17.3	55.8	14.3	14.8	96.6	76.8	0.5	5.8	2.2	247	38	39	6	1	13	5	+76
7	Elgin Baylor E. Baylor	6	366		61.0	21.8				23.3	43.8	53.2				14.3	18.8	76.1	58.5					131					26
8	Giannis Antetokounmpo G. Antetokounmpo	5	286	38.1	57.2	13.8	4.4	1.6	0.8	20.2	31.8	63.5	0.6	3.4	17.6	16.2	19.6	82.7	70.8	2.8	11.0	4.6	190	69	22	8	4	23	11	+77
9	LeBron James L. James	5	285	42.1	57.0	8.6	5.6	1.0	0.6	19.6	32.6	60.1	6.0	9.6	62.5	11.8	14.2	83.1	73.4	2.6	6.0	3.8	211	43	28	5	3	19	7	+41
10	Allen Iverson A. Iverson	5	279	44.1	55.8	4.6	5.0	2.8	0.4	18.4	33.6	54.8	2.4	4.6	52.2	16.6	19.2	86.5	66.4	0.6	4.0	3.2	221	23	25	14	2	16	6	+60
11	Kareem Abdul-Jabbar K. Abdul-Jabbar	5	267		53.4	13.8	6.0			21.2	31.6	67.1				11.0	14.0	78.6	70.7					69	30
12	Rick Barry R. Barry	5	288	45.0	57.6	10.8	6.6	5.0	0.3	22.2	39.6	56.1				13.2	14.4	91.7	62.7	1.0	7.0	2.0	225	54	33	15	1	2	14
13	Devin Booker D. Booker	4	249	41.7	62.3	5.8	4.8	1.3	0.8	20.8	36.5	56.8	5.3	10.8	48.8	15.5	17.8	87.3	70.2	1.0	4.8	4.3	167	23	19	5	3	17	13	-7
14	Kyrie Irving K. Irving	4	226	38.0	56.5	4.5	4.8	2.8	0.3	19.0	30.5	62.3	8.3	11.8	70.2	10.3	10.8	95.3	80.2	1.3	3.3	2.5	152	18	19	11	1	10	9	+74
15	Dominique Wilkins D. Wilkins	4	221	40.5	55.3	6.3	2.3	2.5	1.0	19.5	31.0	62.9	0.3	1.0	25.0	16.0	19.8	81.0	69.6	3.0	3.3	2.8	162	25	9	10	4	11	8
16	Luka Dončić L. Dončić	3	186	42.7	62.0	13.0	7.3	1.7	0.3	21.0	29.3	71.6	5.0	10.0	50.0	15.0	18.7	80.4	82.6	1.7	11.3	4.0	128	39	22	5	1	12	8	+28
17	Joel Embiid J. Embiid	3	182	35.9	60.7	13.7	5.3	0.7	3.0	21.0	33.7	62.4	1.3	3.3	40.0	17.3	19.3	89.7	71.9	4.3	9.3	2.7	108	41	16	2	9	8	7	+47
18	Jayson Tatum J. Tatum	3	167	42.5	55.7	7.7	4.0	0.0	0.7	17.3	30.7	56.5	6.3	10.7	59.4	14.7	16.7	88.0	73.2	1.7	6.0	2.3	128	23	12	0	2	7	9	+23
19	Bradley Beal B. Beal	3	168	39.5	56.0	4.7	4.0	1.0	0.3	18.0	31.7	56.8	6.7	11.3	58.8	13.3	15.0	88.9	73.2	2.3	2.3	6.7	119	14	12	3	1	20	12	-17
20	Karl-Anthony Towns K. Towns	3	178	38.5	59.3	13.3	3.0	0.3	0.3	19.7	32.7	60.2	7.7	11.3	67.6	12.3	15.0	82.2	75.6	3.0	10.3	5.0	115	40	9	1	1	15	11	+23
21	Anthony Davis A. Davis	3	167	39.9	55.7	18.3	2.7	0.3	3.0	20.7	31.0	66.7	1.3	2.0	66.7	13.0	15.0	86.7	74.0	5.7	12.7	1.7	120	55	8	1	9	5	5	+43
22	Russell Westbrook R. Westbrook	3	169	39.4	56.3	8.3	9.3	2.3	0.3	21.0	40.7	51.6	4.7	13.0	35.9	9.7	12.7	76.3	60.9	1.7	6.7	4.3	118	25	28	7	1	13	12	+11
23	Kevin Durant K. Durant	3	162	42.9	54.0	5.7	6.0	1.7	0.3	19.0	31.0	61.3	5.7	10.7	53.1	10.3	12.0	86.1	74.4	0.7	5.0	4.7	129	17	18	5	1	14	5	+19
24	Adrian Dantley A. Dantley	3	165	43.3	55.0	9.3	4.0	0.3	0.3	21.0	30.3	69.2	0.0	0.0		13.0	16.0	81.3	73.6	6.0	3.3	2.3	130	28	12	1	1	7	13
25	George Gervin G. Gervin	3	171	38.3	57.0	3.3	2.7	1.7	1.0	22.3	40.3	55.4	0.5	1.0	50.0	12.0	14.3	83.7	61.1				115	10	8	5	3		5