Wilt Chamberlain has dropped the most points in a game with 20+ minutes played, with 100 points against the Knicks on March 2, 1962.

Interpreted as:

NBA most points by a player in a regular-season game in 20 or more minutes

	NAME	PTS	MIN	DATE	TM		OPP	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF	+/-
1	Wilt Chamberlain W. Chamberlain	100	48	3/2/1962	PHI		NYK	25	2			36	63	57.1				28	32	87.5	64.9				2
2	Kobe Bryant K. Bryant	81	42	1/22/2006	LAL	vs	TOR	6	2	3	1	28	46	60.9	7	13	53.8	18	20	90.0	73.9	2	4	3	1	+25
3	Wilt Chamberlain W. Chamberlain	78	63	12/8/1961	PHI	vs	LAL	43	1			31	62	50.0				16	31	51.6	51.6				4
4	Luka Dončić L. Dončić	73	45	1/26/2024	DAL	@	ATL	10	7	1	0	25	33	75.8	8	13	61.5	15	16	93.8	91.2	0	10	4	1	+13
5	David Thompson D. Thompson	73	43	4/9/1978	DEN	@	DET	7	2	0	1	28	38	73.7				17	20	85.0	78.0	3	4	4	2
6	Wilt Chamberlain W. Chamberlain	73	48	11/16/1962	SFW	@	NYK	14	1			29	43	67.4				15	19	78.9	71.1				0
7	Wilt Chamberlain W. Chamberlain	73	48	1/13/1962	PHI	vs	CHI	36	0			29	48	60.4				15	25	60.0	61.9				2
8	Wilt Chamberlain W. Chamberlain	72	48	11/3/1962	SFW	@	LAL	18	1			29	48	60.4				14	18	77.8	64.4				0
9	Damian Lillard D. Lillard	71	39	2/26/2023	POR	vs	HOU	6	6	0	0	22	38	57.9	13	22	59.1	14	14	100.0	80.4	1	5	2	0	+21
10	Donovan Mitchell D. Mitchell	71	50	1/2/2023	CLE	vs	CHI	8	11	0	1	22	34	64.7	7	15	46.7	20	25	80.0	78.9	3	5	4	3	+19
11	David Robinson D. Robinson	71	44	4/24/1994	SAS	@	LAC	14	5	0	2	26	41	63.4	1	2	50.0	18	25	72.0	68.3	4	10	8	2
12	Elgin Baylor E. Baylor	71	45	11/15/1960	LAL	@	NYK	25	1			28	48	58.3				15	19	78.9	63.0				5
13	Joel Embiid J. Embiid	70	37	1/22/2024	PHI	vs	SAS	18	5	1	1	24	41	58.5	1	2	50.0	21	23	91.3	68.5	9	9	1	2	+11
14	Devin Booker D. Booker	70	45	3/24/2017	PHX	@	BOS	8	6	3	1	21	40	52.5	4	11	36.4	24	26	92.3	68.0	2	6	5	3	-6
15	Wilt Chamberlain W. Chamberlain	70	48	3/10/1963	SFW	@	SYR	18	3			27	38	71.1				16	22	72.7	73.4				2
16	Michael Jordan M. Jordan	69	50	3/28/1990	CHI	@	CLE	18	6	4	1	23	37	62.2	2	6	33.3	21	23	91.3	73.2	7	11	2	5
17	Pete Maravich P. Maravich	68	43	2/25/1977	NOJ	vs	NYK	6	6	3	2	26	43	60.5				16	19	84.2	66.2	1	5		6
18	Wilt Chamberlain W. Chamberlain	68	48	12/16/1967	PHI	@	CHI	34	2			30	40	75.0				8	22	36.4	68.4				1
19	Wilt Chamberlain W. Chamberlain	67	48	1/11/1963	SFW	vs	LAL	25	1			28	47	59.6				11	17	64.7	61.5				1
20	Wilt Chamberlain W. Chamberlain	67	48	2/25/1962	PHI	vs	NYK	21	1			25	38	65.8				17	22	77.3	70.3				1
21	Wilt Chamberlain W. Chamberlain	67	48	2/17/1962	PHI	@	STL	28	2			26	44	59.1				15	20	75.0	63.4				1
22	Wilt Chamberlain W. Chamberlain	67	48	3/9/1961	PHI	vs	NYK	31	1			27	37	73.0				13	17	76.5	75.3				1
23	Wilt Chamberlain W. Chamberlain	66	48	2/9/1969	LAL	vs	PHX	27	4			29	35	82.9				8	18	44.4	76.9				1
24	Kobe Bryant K. Bryant	65	50	3/16/2007	LAL	vs	POR	7	3	3	0	23	39	59.0	8	12	66.7	11	12	91.7	73.4	1	6	2	3	+4
25	Wilt Chamberlain W. Chamberlain	65	47	2/7/1966	PHI	vs	LAL	29	2			28	43	65.1				9	20	45.0	62.7				3

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Results may be incomplete. StatMuse has complete game-level data for minutes played going back to the 1982-83 season.

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Mon 12/22	ORL	@	GSW	10:00 PM
Thu 12/25	DAL	@	GSW	5:00 PM
Sun 12/28	GSW	@	TOR	3:30 PM
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Wilt Chamberlain has dropped the most points in a game with 20+ minutes played, with 100 points against the Knicks on March 2, 1962.

Interpreted as:

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