The Detroit Pistons had their highest point differential in a game versus the Celtics on January 31, 2003, with a 52 point differential.

Interpreted as:

pistons largest margin of victory in a regular-season game

	TEAM	DIFF	DATE	TM		OPP	RESULT	MIN	PTS	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF
1	Pistons	52	1/31/2003	DET	@	BOS	W 118-66	240	118	49	24	7	3	41	79	51.9	12	32	37.5	24	31	77.4	63.7	7	42	9	15
2	Pistons	46	3/17/2025	DET	@	NOP	W 127-81	240	127	50	33	10	7	46	84	54.8	13	35	37.1	22	29	75.9	65.6	11	39	13	19
3	Pistons	46	4/2/1987	DET	vs	IND	W 119-73	240	119	66	29	6	10	42	79	53.2	0	0		35	51	68.6	58.7	20	46	15	14
4	Pistons	45	12/31/2007	DET	vs	MIL	W 114-69	240	114	36	33	9	4	45	77	58.4	8	15	53.3	16	21	76.2	66.1	7	29	12	22
5	Pistons	44	5/3/1999	DET	@	CHI	W 115-71	240	115	42	27	8	4	47	73	64.4	5	9	55.6	16	19	84.2	70.7	9	33	11	19
6	Pistons	44	1/4/1997	DET	vs	TOR	W 118-74	240	118	51	30	17	6	44	75	58.7	7	15	46.7	23	29	79.3	67.2	14	37	20	25
7	Pistons	44	2/18/1973	DET	vs	KCO	W 144-100	240	144	40	31			56	96	58.3				32	41	78.0	63.1				26
8	Pistons	44	3/23/1969	DET	vs	CHI	W 158-114	240	158	68	32			67	113	59.3				24	32	75.0	62.2				15
9	Pistons	43	3/9/1979	DET	vs	BOS	W 160-117	240	160	57	36	7	4	69	108	63.9				22	35	62.9	64.8	19	38	14	23
10	Pistons	42	11/28/1962	DET	vs	NYK	W 143-101	240	143					62						19	28	67.9					29
11	Pistons	40	2/11/2025	DET	@	CHI	W 132-92	240	132	55	30	10	8	51	96	53.1	18	41	43.9	12	13	92.3	64.9	8	47	14	19
12	Pistons	40	11/28/2012	DET	vs	PHX	W 117-77	240	117	43	28	9	5	40	76	52.6	12	16	75.0	25	35	71.4	64.0	8	35	12	19
13	Pistons	40	1/26/1991	DET	@	ORL	W 121-81	240	121	54	25	8	14	47	83	56.6	1	3	33.3	26	32	81.3	62.3	15	39	17	25
14	Pistons	40	12/27/1983	DET	vs	POR	W 140-100	240	140	57	36	16	10	59	111	53.2	0	1	0.0	22	28	78.6	56.8	22	35	15	25
15	Pistons	40	1/7/1966	DET	vs	STL	W 137-97	240	137					56						25	38	65.8					21
16	Pistons	40	12/26/1958	DET	vs	CIN	W 131-91	240	131					52						27	32	84.4					25
17	Pistons	39	4/12/2015	DET	vs	CHA	W 116-77	240	116	56	33	6	4	41	81	50.6	16	28	57.1	18	23	78.3	63.7	12	44	14	23
18	Pistons	39	4/17/2012	DET	vs	CLE	W 116-77	240	116	41	28	12	10	45	75	60.0	8	18	44.4	18	20	90.0	69.2	7	34	12	19
19	Pistons	37	12/20/1997	DET	vs	PHI	W 115-78	240	115	54	22	13	7	39	87	44.8	4	12	33.3	33	45	73.3	53.8	17	37	7	22
20	Pistons	36	3/2/2019	DET	@	CLE	W 129-93	240	129	51	27	5	8	47	87	54.0	20	37	54.1	15	17	88.2	68.3	9	42	9	24
21	Pistons	36	12/2/2016	DET	@	ATL	W 121-85	240	121	54	28	4	3	48	89	53.9	17	29	58.6	8	12	66.7	64.2	11	43	15	15
22	Pistons	36	11/15/1989	DET	vs	MIA	W 130-94	240	130	50	28	8	4	50	94	53.2	0	1	0.0	30	41	73.2	58.0	19	31	9	23
23	Pistons	36	12/2/1983	DET	vs	ATL	W 128-92	240	128	66	32	10	10	46	103	44.7	0	1	0.0	36	44	81.8	52.3	20	46	17	25
24	Pistons	36	12/6/1961	DET	vs	NYK	W 133-97	240	133					46						41	55	74.5					28
25	Pistons	35	11/28/2007	DET	vs	CLE	W 109-74	240	109	43	30	9	9	45	77	58.4	2	11	18.2	17	23	73.9	62.6	13	30	11	12