D'Angelo Russell has averaged his most career points per game against the Cavaliers, with 22.5 per game.

d'angelo russell highest career ppg by opponent

OPP	PPG	GP	MPG	RPG	APG	SPG	BPG	TPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	MIN	PTS	REB	AST	STL	BLK	TOV	PF	+/-
Cavaliers	22.5	17	31.6	3.5	5.1	1.0	0.2	2.6	8.1	17.3	46.9	3.9	8.7	45.3	2.4	3.1	75.5	538	383	59	87	17	3	44	41	+80
Raptors	21.5	16	30.2	4.4	6.1	0.8	0.3	2.9	7.8	17.0	46.0	3.4	7.9	42.9	2.5	3.2	78.4	483	344	71	98	12	5	47	23	-14
Nets	21.2	10	29.8	4.0	4.7	1.8	0.1	2.6	7.1	15.4	46.1	3.4	7.8	43.6	3.6	4.4	81.8	298	212	40	47	18	1	26	21	-59
Grizzlies	21.1	23	33.1	3.5	6.7	1.0	0.3	3.1	7.3	16.0	45.7	3.2	7.8	40.6	3.3	4.1	81.1	762	486	81	154	24	6	72	47	+64
Hawks	20.2	12	29.9	3.9	6.3	1.3	0.4	3.0	7.3	16.7	44.0	2.9	7.5	38.9	2.6	3.3	79.5	358	242	47	75	15	5	36	22	0
Trail Blazers	20.0	22	32.6	4.0	6.3	0.8	0.3	2.5	7.2	16.4	43.8	2.5	7.6	33.3	3.1	4.3	72.6	717	441	87	138	17	7	55	42	-81
Magic	20.0	22	31.8	3.9	6.0	1.2	0.6	2.5	7.4	16.4	44.9	2.9	7.5	38.6	2.4	2.8	85.5	699	441	85	133	26	14	55	37	+38
Hornets	19.7	18	30.8	3.3	5.9	0.7	0.5	2.6	7.2	16.5	43.8	2.6	7.7	33.3	2.7	3.1	87.3	554	354	59	107	12	9	47	41	-32
Jazz	19.6	22	32.2	3.5	6.1	0.9	0.4	2.5	7.4	16.6	44.5	2.8	6.6	42.5	2.0	2.8	71.0	708	432	78	135	20	8	54	44	-92
Pelicans	19.5	24	31.9	3.6	5.6	1.1	0.4	2.9	6.8	16.3	41.9	2.8	8.5	32.8	3.0	3.7	83.0	766	468	87	134	26	9	70	57	+179
Bucks	19.0	17	30.1	3.6	5.9	0.7	0.1	3.1	6.6	15.2	43.6	3.1	7.0	43.7	2.6	3.1	84.9	512	323	61	101	12	2	52	34	-36
Kings	18.5	24	30.5	2.7	5.9	1.0	0.3	2.8	6.7	14.5	45.8	3.0	7.0	42.6	2.2	3.0	74.6	732	445	65	142	25	8	66	42	+3
Spurs	18.5	19	31.0	3.4	5.7	1.0	0.6	2.3	6.9	16.4	42.4	2.2	6.3	35.3	2.4	3.2	76.7	589	352	64	108	19	11	44	36	-44
76ers	17.5	19	29.0	4.0	5.4	0.8	0.3	2.7	6.6	15.5	42.5	2.3	6.1	37.9	2.1	2.6	79.6	552	333	76	103	16	6	52	29	-119
Suns	17.5	25	29.7	3.6	5.1	1.0	0.4	2.4	6.1	14.6	41.8	2.0	5.8	33.8	3.4	4.4	77.3	743	438	91	128	25	10	59	57	-58
Wizards	17.5	14	32.1	4.0	6.4	1.2	0.4	3.6	6.4	15.9	40.5	2.1	7.6	28.3	2.5	3.3	76.1	450	245	56	89	17	6	51	24	-102
Timberwolves	17.3	16	32.5	3.4	5.4	1.4	0.3	2.9	5.9	15.3	38.4	2.4	7.2	33.9	3.1	4.0	78.1	521	277	55	86	22	5	46	31	-56
Bulls	17.0	18	30.7	3.0	5.3	0.9	0.1	2.7	6.1	13.6	44.9	2.8	7.6	37.2	1.9	2.4	81.4	553	306	54	96	16	2	48	32	+119
Celtics	16.8	18	29.4	3.8	6.8	1.1	0.4	3.6	6.3	14.8	42.7	2.1	6.9	30.4	2.1	2.7	77.1	529	303	69	123	20	8	65	26	-101
Pacers	16.6	16	28.5	3.4	5.9	0.8	0.3	2.2	6.1	13.9	43.5	1.9	5.6	34.4	2.5	2.6	97.6	455	265	54	95	12	5	35	28	-26
Clippers	16.3	22	31.4	2.9	5.5	0.9	0.4	2.5	6.0	14.3	42.0	2.5	6.3	38.8	1.8	2.3	78.4	690	358	64	121	19	8	56	42	-159
Warriors	16.2	20	29.7	3.2	6.2	1.3	0.2	2.2	5.8	13.7	42.0	2.5	7.0	35.7	2.2	2.6	84.3	594	323	63	123	25	4	43	41	-75
Mavericks	16.1	25	29.6	3.5	5.8	0.9	0.1	2.0	6.0	14.7	40.9	2.2	6.8	31.8	1.9	2.3	84.2	740	402	87	146	22	3	50	53	-80
Thunder	16.0	23	28.8	2.9	5.3	1.4	0.1	2.9	5.8	12.9	44.8	2.2	6.2	35.9	2.2	2.6	84.7	662	367	67	122	32	3	67	35	-86
Nuggets	15.7	23	28.9	3.0	5.9	1.0	0.3	2.6	5.4	13.0	41.8	2.4	5.9	41.5	2.3	3.3	71.1	664	360	68	135	23	6	60	47	-137