Dwyane Wade averaged 26.3 points, 6.3 assists and 5.1 rebounds in 12 games versus the Spurs between the 2004-05 and 2010-11 seasons.
| NAME | DATE | TM | OPP | MIN | PTS | REB | AST | STL | BLK | FGM | FGA | FG% | 3PM | 3PA | 3P% | FTM | FTA | FT% | TS% | OREB | DREB | TOV | PF | +/- | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | D. Wade | 2/13/2005 |  MIA | vs |  SAS | 44 | 28 | 5 | 6 | 4 | 2 | 12 | 26 | 46.2 | 0 | 0 | 4 | 4 | 100.0 | 50.4 | 1 | 4 | 5 | 4 | +16 | |
| 2 | | D. Wade | 12/7/2005 | MIA | @ | SAS | 40 | 31 | 6 | 10 | 1 | 0 | 8 | 20 | 40.0 | 0 | 1 | 0.0 | 15 | 17 | 88.2 | 56.4 | 2 | 4 | 5 | 4 | -14 |
| 3 | | D. Wade | 1/20/2006 | MIA | vs | SAS | 41 | 36 | 4 | 1 | 3 | 0 | 14 | 29 | 48.3 | 1 | 2 | 50.0 | 7 | 8 | 87.5 | 55.4 | 2 | 2 | 5 | 3 | -13 |
| 4 | | D. Wade | 11/22/2006 | MIA | @ | SAS | 34 | 18 | 5 | 6 | 2 | 2 | 7 | 17 | 41.2 | 0 | 1 | 0.0 | 4 | 5 | 80.0 | 46.9 | 0 | 5 | 5 | 3 | -17 |
| 5 | | D. Wade | 2/11/2007 | MIA | vs | SAS | 41 | 26 | 4 | 7 | 1 | 3 | 10 | 19 | 52.6 | 1 | 2 | 50.0 | 5 | 7 | 71.4 | 58.9 | 1 | 3 | 6 | 3 | +9 |
| 6 | | D. Wade | 1/24/2008 | MIA | vs | SAS | 41 | 27 | 6 | 9 | 4 | 1 | 10 | 23 | 43.5 | 0 | 1 | 0.0 | 7 | 12 | 58.3 | 47.7 | 1 | 5 | 4 | 2 | +4 |
| 7 | | D. Wade | 11/7/2008 | MIA | @ | SAS | 36 | 33 | 10 | 9 | 3 | 0 | 14 | 25 | 56.0 | 0 | 1 | 0.0 | 5 | 6 | 83.3 | 59.7 | 2 | 8 | 3 | 1 | +24 |
| 8 | | D. Wade | 1/5/2009 | MIA | vs | SAS | 46 | 24 | 4 | 12 | 4 | 0 | 10 | 26 | 38.5 | 1 | 5 | 20.0 | 3 | 5 | 60.0 | 42.6 | 2 | 2 | 5 | 0 | -12 |
| 9 | | D. Wade | 12/31/2009 | MIA | @ | SAS | 29 | 16 | 2 | 6 | 3 | 0 | 6 | 18 | 33.3 | 1 | 5 | 20.0 | 3 | 6 | 50.0 | 38.8 | 0 | 2 | 7 | 3 | -19 |
| 10 | | D. Wade | 3/16/2010 | MIA | vs | SAS | 43 | 28 | 3 | 5 | 3 | 1 | 11 | 26 | 42.3 | 1 | 4 | 25.0 | 5 | 8 | 62.5 | 47.4 | 1 | 2 | 5 | 4 | -12 |
| 11 | | D. Wade | 3/4/2011 | MIA | @ | SAS | 27 | 19 | 3 | 1 | 0 | 0 | 8 | 18 | 44.4 | 1 | 3 | 33.3 | 2 | 2 | 100.0 | 50.3 | 0 | 3 | 5 | 3 | -24 |
| 12 | | D. Wade | 3/14/2011 | MIA | vs | SAS | 39 | 29 | 9 | 4 | 2 | 2 | 11 | 23 | 47.8 | 0 | 1 | 0.0 | 7 | 7 | 100.0 | 55.6 | 3 | 6 | 3 | 3 | +27 |
| Average | 38.6 | 26.3 | 5.1 | 6.3 | 2.5 | 0.9 | 10.1 | 22.5 | 44.8 | 0.5 | 2.2 | 23.1 | 5.6 | 7.3 | 77.0 | 51.1 | 1.3 | 3.8 | 4.8 | 2.8 | -2.6 | ||||||
| Total | 463 | 315 | 61 | 76 | 30 | 11 | 121 | 270 | 44.8 | 6 | 26 | 23.1 | 67 | 87 | 77.0 | 51.1 | 15 | 46 | 58 | 33 | -31 |
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