Dwyane Wade averaged 27.9 points, 7.8 assists and 4.5 rebounds in 10 games versus Kobe Bryant between the 2005-06 and 2009-10 seasons.
| NAME | DATE | TM | OPP | MIN | PTS | REB | AST | STL | BLK | FGM | FGA | FG% | 3PM | 3PA | 3P% | FTM | FTA | FT% | TS% | OREB | DREB | TOV | PF | +/- | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | D. Wade | 12/25/2005 |  MIA | vs |  LAL | 30 | 18 | 4 | 5 | 1 | 0 | 5 | 15 | 33.3 | 0 | 0 | 8 | 13 | 61.5 | 43.4 | 1 | 3 | 2 | 4 | +2 | |
| 2 | | D. Wade | 1/16/2006 | MIA | @ | LAL | 42 | 34 | 2 | 7 | 0 | 1 | 11 | 24 | 45.8 | 0 | 3 | 0.0 | 12 | 16 | 75.0 | 54.8 | 0 | 2 | 1 | 1 | -9 |
| 3 | | D. Wade | 12/25/2006 | MIA | vs | LAL | 41 | 40 | 4 | 11 | 4 | 4 | 12 | 20 | 60.0 | 1 | 1 | 100.0 | 15 | 16 | 93.8 | 74.0 | 0 | 4 | 4 | 2 | +20 |
| 4 | | D. Wade | 1/15/2007 | MIA | @ | LAL | 42 | 35 | 5 | 8 | 4 | 0 | 12 | 25 | 48.0 | 0 | 2 | 0.0 | 11 | 13 | 84.6 | 57.0 | 2 | 3 | 4 | 4 | -2 |
| 5 | | D. Wade | 2/10/2008 | MIA | vs | LAL | 41 | 19 | 5 | 9 | 4 | 0 | 7 | 17 | 41.2 | 0 | 1 | 0.0 | 5 | 6 | 83.3 | 48.4 | 1 | 4 | 9 | 2 | -7 |
| 6 | | D. Wade | 2/28/2008 | MIA | @ | LAL | 29 | 18 | 1 | 3 | 0 | 1 | 6 | 17 | 35.3 | 2 | 3 | 66.7 | 4 | 7 | 57.1 | 44.8 | 1 | 0 | 4 | 5 | -27 |
| 7 | | D. Wade | 12/19/2008 | MIA | vs | LAL | 38 | 35 | 6 | 3 | 3 | 2 | 13 | 25 | 52.0 | 2 | 4 | 50.0 | 7 | 10 | 70.0 | 59.5 | 3 | 3 | 6 | 3 | +1 |
| 8 | | D. Wade | 1/11/2009 | MIA | @ | LAL | 41 | 27 | 5 | 9 | 2 | 2 | 10 | 22 | 45.5 | 1 | 3 | 33.3 | 6 | 7 | 85.7 | 53.8 | 0 | 5 | 3 | 3 | 0 |
| 9 | | D. Wade | 12/4/2009 | MIA | @ | LAL | 42 | 26 | 8 | 9 | 0 | 2 | 7 | 21 | 33.3 | 0 | 1 | 0.0 | 12 | 18 | 66.7 | 45.0 | 3 | 5 | 2 | 4 | +8 |
| 10 | | D. Wade | 3/4/2010 | MIA | vs | LAL | 42 | 27 | 5 | 14 | 1 | 0 | 9 | 21 | 42.9 | 1 | 3 | 33.3 | 8 | 9 | 88.9 | 54.1 | 3 | 2 | 6 | 3 | +5 |
| Average | 38.8 | 27.9 | 4.5 | 7.8 | 1.9 | 1.2 | 9.2 | 20.7 | 44.4 | 0.7 | 2.1 | 33.3 | 8.8 | 11.5 | 76.5 | 54.2 | 1.4 | 3.1 | 4.1 | 3.1 | -0.9 | ||||||
| Total | 388 | 279 | 45 | 78 | 19 | 12 | 92 | 207 | 44.4 | 7 | 21 | 33.3 | 88 | 115 | 76.5 | 54.2 | 14 | 31 | 41 | 31 | -9 |
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