T.J. Watt had the most sacks in the AFC in 2021, with 22.5 sacks.

Interpreted as:

afc defensive sack leaders 2021 season

	NAME	SCK	SEASON	TM	GP	TKL	AST	COMB	SCKY	INT	INT YDS	INT TD	FF	FR	FR TD
1	T.J. Watt	22.5	2021	PIT	15	48	16	64	111.5	0	0	0	5	3	0
2	Myles Garrett M. Garrett	16.0	2021	CLE	17	33	18	51	91.5	0	0	0	1	1	1
3	Trey Hendrickson T. Hendrickson	14.0	2021	CIN	16	20	14	34	96.5	0	0	0	3	0	0
4	Matthew Judon M. Judon	12.5	2021	NE	17	38	22	60	85	0	0	0	0	1	0
5	Harold Landry III H. Landry III	12.0	2021	TEN	17	51	24	75	80	0	0	0	1	0	0
6	Joey Bosa J. Bosa	10.5	2021	LAC	16	36	15	51	70	0	0	0	7	0	0
7	Cameron Heyward C. Heyward	10.0	2021	PIT	17	53	36	89	55.5	1	0	0	1	1	0
8	Yannick Ngakoue Y. Ngakoue	10.0	2021	LV	17	17	11	28	50	0	0	0	2	0	0
9	Jadeveon Clowney J. Clowney	9.0	2021	CLE	14	24	13	37	83.5	0	0	0	2	0	0
10	Denico Autry D. Autry	9.0	2021	TEN	17	25	6	31	60.5	0	0	0	0	0	0
11	Chris Jones C. Jones	9.0	2021	KC	14	18	9	27	65.5	0	0	0	1	1	0
12	Emmanuel Ogbah E. Ogbah	9.0	2021	MIA	17	26	15	41	64	0	0	0	1	1	0
13	Jeffery Simmons J. Simmons	8.5	2021	TEN	17	42	12	54	64.5	0	0	0	0	0	0
14	Jaelan Phillips J. Phillips	8.5	2021	MIA	17	23	19	42	71.5	0	0	0	0	1	0
15	Maxx Crosby M. Crosby	8.0	2021	LV	17	36	20	56	52.5	0	0	0	0	0	0
16	Jonathan Greenard J. Greenard	8.0	2021	HOU	12	23	10	33	50	0	0	0	2	0	0
17	Sam Hubbard S. Hubbard	7.5	2021	CIN	16	33	29	62	32	0	0	0	1	2	0
18	Josh Hines-Allen J. Hines-Allen	7.5	2021	JAX	16	46	25	71	70	1	11	0	1	1	0
19	Mario Addison M. Addison	7.0	2021	BUF	17	20	9	29	34	0	0	0	2	0	0
20	DeForest Buckner D. Buckner	7.0	2021	IND	17	40	28	68	55.5	0	0	0	0	0	0
21	Larry Ogunjobi L. Ogunjobi	7.0	2021	CIN	16	29	20	49	51.5	0	0	0	0	0	0
22	Chris Wormley C. Wormley	7.0	2021	PIT	15	29	22	51	55.5	0	0	0	1	0	0
23	Tyus Bowser T. Bowser	7.0	2021	BAL	17	33	26	59	56	0	0	0	2	0	0
24	Shelby Harris S. Harris	6.0	2021	DEN	16	24	25	49	44	0	0	0	1	0	0
25	Al-Quadin Muhammad A. Muhammad	6.0	2021	IND	17	32	16	48	51	0	0	0	1	0	0

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T.J. Watt had the most sacks in the AFC in 2021, with 22.5 sacks.

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