The St. Louis Cardinals had their lowest point differential in a home game on November 8, 1981 and on December 3, 1944, with a -42-point differential.
Interpreted as:
arizona cardinals largest home loss in a regular-season game| TEAM | DIFF | DATE | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Cardinals | -42 | 11/8/1981 | vs | L 10-52 | 1 | 13 | 239 | 452 | ||||
| 2 |  | Cardinals | -42 | 12/3/1944 | vs | L 7-49 | 1 | 10 | ||||||
| 3 | | Cardinals | -41 | 11/24/1977 | vs | L 14-55 | 2 | 13 | 210 | 503 | ||||
| 4 | | Cardinals | -41 | 11/26/1939 | vs | L 7-48 | ||||||||
| 5 | | Cardinals | -39 | 10/25/1953 | vs | L 17-56 | 2 | 12 | 195 | 542 | ||||
| 6 |  | Cardinals | -38 | 9/14/2003 | vs | L 0-38 | 0 | 18 | 286 | 323 | 55.6 | 0.0 | ||
| 7 | | Cardinals | -38 | 9/24/1950 | vs | L 7-45 | 1 | 12 | 265 | 439 | ||||
| 8 |  | Cardinals | -37 | 12/16/1989 | vs | L 0-37 | 0 | 7 | 101 | 475 | ||||
| 9 | | Cardinals | -35 | 10/18/2018 | vs | L 10-45 | 1 | 14 | 223 | 309 | 28.6 | 0.0 | ||
| 10 | | Cardinals | -32 | 10/24/1954 | vs | L 3-35 | 0 | 8 | 160 | 327 | ||||
| 11 | | Cardinals | -31 | 11/24/1985 | vs | L 3-34 | 0 | 13 | 221 | 313 | ||||
| 12 | | Cardinals | -31 | 11/12/1961 | vs | L 14-45 | 2 | 21 | 214 | 372 | ||||
| 13 | | Cardinals | -31 | 11/20/1955 | vs | L 0-31 | 0 | 7 | 106 | 329 | ||||
| 14 | | Cardinals | -31 | 9/26/1954 | vs | L 10-41 | 1 | 7 | 176 | 381 | ||||
| 15 | | Cardinals | -30 | 1/3/2016 | vs | L 6-36 | 1 | 16 | 232 | 354 | 41.7 | 0.0 | ||
| 16 | | Cardinals | -30 | 10/15/1972 | vs | L 3-33 | 0 | 10 | 151 | 390 | ||||
| 17 | | Cardinals | -30 | 9/28/1958 | vs | L 7-37 | 1 | 16 | 330 | 295 | ||||
| 18 | | Cardinals | -29 | 12/21/2014 | vs | L 6-35 | 0 | 17 | 216 | 596 | 20.0 | 100.0 | ||
| 19 | | Cardinals | -28 | 12/7/2025 | vs | L 17-45 | 2 | 17 | 314 | 530 | 33.3 | 0.0 | ||
| 20 | | Cardinals | -28 | 9/29/2024 | vs | L 14-42 | 2 | 17 | 296 | 449 | 36.4 | 66.7 | ||
| 21 | | Cardinals | -28 | 11/21/2022 | vs | L 10-38 | 1 | 19 | 314 | 387 | 50.0 | 0.0 | ||
| 22 | | Cardinals | -28 | 9/8/1996 | vs | L 10-38 | 1 | 13 | 203 | 331 | 27.3 | 100.0 | ||
| 23 | | Cardinals | -28 | 10/27/1991 | vs | L 0-28 | 0 | 7 | 158 | 354 | 28.6 | 0.0 | ||
| 24 | | Cardinals | -28 | 9/30/1990 | vs | L 10-38 | 1 | 13 | 192 | 436 | ||||
| 25 | | Cardinals | -28 | 12/17/1966 | vs | L 10-38 | 1 | 12 | 227 | 428 | ||||
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More Cardinals Stats
Team Leaders 
PASS
3,366
Brissett
RUSH
333
Carter
REC
1,239
McBride
Team Rankings
PPG
20.9
23rd
OPP PPG
28.7
29th
RUSH YDS/G
93.1
31st
PASS YDS/G
256.1
5th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |