The Buffalo Bills had a 28-22-4 record against the spread against the NFC between the 2010 and 2022 seasons.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 9/19/2010 | 0-1 | +525 | @ | -750 | L 7-34 | +12.5 | -14.5 (N) | 43 | -2 (U) | 1 | 14 | 186 | 346 | 33.3 | 0.0 | ||
| 2 | | Bills | 11/7/2010 | 0-0-1 | +130 | vs | -150 | L 19-22 | +3 | 0 (P) | 41 | 0 (P) | 3 | 22 | 340 | 283 | 62.5 | 50.0 | ||
| 3 | | Bills | 11/14/2010 | 1-0 | -125 | vs | +105 | W 14-12 | -1 | +1 (Y) | 45 | -19 (U) | 2 | 12 | 288 | 390 | 33.3 | 0.0 | ||
| 4 | | Bills | 12/5/2010 | 0-1 | +205 | @ | -245 | L 14-38 | +5.5 | -18.5 (N) | 43 | +9 (O) | 2 | 10 | 239 | 387 | 25.0 | 100.0 | ||
| 5 | | Bills | 10/9/2011 | 1-0 | +150 | vs | -170 | W 31-24 | +3 | +10 (Y) | 53 | +2 (O) | 4 | 21 | 331 | 489 | 42.9 | |||
| 6 | | Bills | 10/16/2011 | 1-0 | +165 | @ | -185 | L 24-27 | +3.5 | +0.5 (Y) | 49 | +2 (O) | 3 | 17 | 374 | 414 | 45.5 | 50.0 | ||
| 7 | | Bills | 10/30/2011 | 1-0 | -210 | vs | +180 | W 23-0 | -4 | +19 (Y) | 46 | -23 (U) | 2 | 17 | 390 | 178 | 50.0 | |||
| 8 | | Bills | 11/13/2011 | 0-1 | +185 | @ | -215 | L 7-44 | +5.5 | -31.5 (N) | 48 | +3 (O) | 1 | 20 | 271 | 433 | 28.6 | 0.0 | ||
| 9 | | Bills | 10/7/2012 | 0-1 | +400 | @ | -500 | L 3-45 | +10 | -32 (N) | 45.5 | +2.5 (O) | 0 | 10 | 204 | 621 | 20.0 | |||
| 10 | | Bills | 10/14/2012 | 1-0 | +200 | @ | -240 | W 19-16 | +5 | +8 (Y) | 44.5 | -9.5 (U) | 2 | 19 | 306 | 332 | 30.8 | |||
| 11 | | Bills | 12/9/2012 | 0-1 | -185 | vs | +165 | L 12-15 | -3.5 | -6.5 (N) | 42.5 | -15.5 (U) | 1 | 17 | 281 | 285 | 25.0 | |||
| 12 | | Bills | 12/16/2012 | 0-1 | +190 | vs | -230 | L 17-50 | +4.5 | -28.5 (N) | 44 | +23 (O) | 2 | 21 | 333 | 466 | 38.5 | 0.0 | ||
| 13 | | Bills | 9/15/2013 | 1-0 | +155 | vs | -175 | W 24-23 | +3.5 | +4.5 (Y) | 43.5 | +3.5 (O) | 2 | 24 | 436 | 308 | 42.9 | |||
| 14 | | Bills | 10/27/2013 | 0-1 | +450 | @ | -600 | L 17-35 | +10.5 | -7.5 (N) | 48.5 | +3.5 (O) | 2 | 20 | 299 | 386 | 38.5 | 0.0 | ||
| 15 | | Bills | 12/1/2013 | 0-1 | -210 | vs | +180 | L 31-34 | -4.5 | -7.5 (N) | 48 | +17 (O) | 4 | 19 | 405 | 423 | 35.7 | |||
| 16 | | Bills | 12/8/2013 | 0-1 | +135 | @ | -155 | L 6-27 | +3 | -18 (N) | 43 | -10 (U) | 0 | 14 | 214 | 246 | 9.1 | |||
| 17 | | Bills | 9/7/2014 | 1-0 | +260 | @ | -320 | W 23-20 | +7 | +10 (Y) | 47.5 | -4.5 (U) | 2 | 15 | 360 | 427 | 33.3 | |||
| 18 | | Bills | 10/5/2014 | 1-0 | +195 | @ | -235 | W 17-14 | +4.5 | +7.5 (Y) | 43 | -12 (U) | 1 | 19 | 343 | 273 | 31.3 | |||
| 19 | | Bills | 10/19/2014 | 0-1 | -270 | vs | +230 | W 17-16 | -6.5 | -5.5 (N) | 43.5 | -10.5 (U) | 2 | 22 | 373 | 276 | 33.3 | 100.0 | ||
| 20 | | Bills | 12/14/2014 | 1-0 | +160 | vs | -185 | W 21-13 | +4 | +12 (Y) | 50 | -16 (U) | 1 | 13 | 253 | 333 | 25.0 | |||
| 21 | | Bills | 10/4/2015 | 0-1 | -260 | vs | +210 | L 10-24 | -6 | -20 (N) | 46 | -12 (U) | 1 | 14 | 313 | 303 | 18.8 | 33.3 | ||
| 22 | | Bills | 12/13/2015 | 0-1 | +100 | @ | -120 | L 20-23 | +1 | -2 (N) | 48 | -5 (U) | 2 | 18 | 412 | 348 | 37.5 | |||
| 23 | | Bills | 12/20/2015 | 0-1 | -130 | @ | +110 | L 25-35 | -2 | -12 (N) | 45.5 | +14.5 (O) | 3 | 21 | 452 | 431 | 38.5 | 33.3 | ||
| 24 | | Bills | 12/27/2015 | 1-0 | -290 | vs | +240 | W 16-6 | -6.5 | +3.5 (Y) | 42 | -20 (U) | 2 | 19 | 408 | 307 | 42.9 | 0.0 | ||
| 25 | | Bills | 9/25/2016 | 1-0 | +185 | vs | -215 | W 33-18 | +4.5 | +19.5 (Y) | 48 | +3 (O) | 4 | 16 | 297 | 348 | 30.8 | |||
| Average | 1.0 | 2.6 | 19.7 | 340.3 | 353.2 | 40.2 | 0.0 | |||||||||||||
| Total | 28-22-4 | 141 | 1,064 | 18,376 | 19,074 | 40.2 | 43.8 | |||||||||||||
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| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |