The Buffalo Bills have their best record in the regular-season and playoffs versus the Panthers, with a record of 7-2.
| OPP | REC | W% | GP | W | L | T | TD | PTS | PPG | OPP PTS | OPP PPG | 1DWN | 3DWN% | 4DWN% | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 7-2 | .778 | 9 | 7 | 2 | 0 | 23 | 213 | 23.7 | 124 | 13.8 | 153 | 40.8 | 50.0 | |
| 2 | 8-4-1 | .654 | 13 | 8 | 4 | 1 | 33 | 274 | 21.1 | 273 | 21.0 | 255 | 57.1 | ||
| 3 | 11-6 | .647 | 17 | 11 | 6 | 0 | 46 | 393 | 23.1 | 306 | 18.0 | 343 | |||
| 4 | 9-5 | .643 | 14 | 9 | 5 | 0 | 33 | 285 | 20.4 | 251 | 17.9 | 264 | |||
| 5 | 8-5 | .615 | 13 | 8 | 5 | 0 | 40 | 326 | 25.1 | 297 | 22.8 | 229 | |||
| 6 | 9-6 | .600 | 15 | 9 | 6 | 0 | 49 | 400 | 26.7 | 325 | 21.7 | 281 | |||
| 7 | 8-6 | .571 | 14 | 8 | 6 | 0 | 35 | 303 | 21.6 | 303 | 21.6 | 273 | |||
| 8 | 24-18-1 | .570 | 43 | 24 | 18 | 1 | 122 | 1,042 | 24.2 | 904 | 21.0 | 792 | |||
| 9 | 73-58 | .557 | 131 | 73 | 58 | 0 | 320 | 2,820 | 21.5 | 2,601 | 19.9 | 2,441 | |||
| 10 | 31-26-1 | .543 | 58 | 31 | 26 | 1 | 155 | 1,314 | 22.7 | 1,224 | 21.1 | 1,087 | |||
| 11 | 39-33-1 | .541 | 73 | 39 | 33 | 1 | 174 | 1,507 | 20.6 | 1,441 | 19.7 | 1,351 | |||
| 12 | 8-7 | .533 | 15 | 8 | 7 | 0 | 34 | 281 | 18.7 | 262 | 17.5 | 282 | |||
| 13 | 11-10 | .524 | 21 | 11 | 10 | 0 | 53 | 468 | 22.3 | 428 | 20.4 | 406 | 42.6 | 52.4 | |
| 14 | 18-17 | .514 | 35 | 18 | 17 | 0 | 96 | 826 | 23.6 | 790 | 22.6 | 665 | |||
| 15 | 22-21 | .512 | 43 | 22 | 21 | 0 | 123 | 984 | 22.9 | 966 | 22.5 | 825 | |||
| 16 | 7-7 | .500 | 14 | 7 | 7 | 0 | 24 | 247 | 17.6 | 327 | 23.4 | 241 | 33.0 | 66.7 | |
| 17 | 61-63-1 | .492 | 125 | 61 | 63 | 1 | 311 | 2,660 | 21.3 | 2,658 | 21.3 | 2,294 | |||
| 18 | 7-8 | .467 | 15 | 7 | 8 | 0 | 46 | 386 | 25.7 | 370 | 24.7 | 331 | |||
| 19 | 6-7 | .462 | 13 | 6 | 7 | 0 | 32 | 255 | 19.6 | 308 | 23.7 | 223 | |||
| 20 | 11-13 | .458 | 24 | 11 | 13 | 0 | 56 | 489 | 20.4 | 441 | 18.4 | 447 | |||
| 21 | 14-17 | .452 | 31 | 14 | 17 | 0 | 72 | 604 | 19.5 | 660 | 21.3 | 584 | |||
| 22 | 6-8 | .429 | 14 | 6 | 8 | 0 | 32 | 281 | 20.1 | 325 | 23.2 | 277 | |||
| 23 | 6-8 | .429 | 14 | 6 | 8 | 0 | 34 | 286 | 20.4 | 306 | 21.9 | 254 | |||
| 24 | 6-8 | .429 | 14 | 6 | 8 | 0 | 28 | 238 | 17.0 | 305 | 21.8 | 261 | |||
| 25 | 6-8 | .429 | 14 | 6 | 8 | 0 | 27 | 229 | 16.4 | 294 | 21.0 | 224 | |||
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More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |